RESUMEN
bicyclic [3.2.1] octane neolignans have garnered increasing interest, because of their unique structural features and biological activities. This study describes the isolation and identification of a new bicyclic octane neolignan 1 obtained through fractionation of the crude extract of the stem of Aniba firmula (Lauraceae family). The structure of bicyclic octane neolignan 1 was determined through NMR analysis and mass spectrometry data.
Asunto(s)
Lauraceae , Lignanos , Lignanos/química , Octanos , Lauraceae/química , Espectroscopía de Resonancia MagnéticaRESUMEN
The phytochemical investigation of the stem bark crude extract of Aniba firmula (Lauraceae) led to the isolation of undescribed bicyclic [3.2.1] octane neolignans, 1 and 2, characterized by unusual bicyclic patterns and two other known bicyclic neolignans 3 and 4. Anti-inflammatory bicyclic [3.2.1] octane neolignans metabolites were previously reported in the literature, and the A. firmula stands out in the Lauraceae family as a source of potentially bioactive compounds. Thus, herein the anti-inflammatory potential of four isolated compounds from A. firmula was accessed via an ex vivo anti-inflammatory model that included plasmatic quantification of the prostaglandin E2 (PGE2) inflammatory mediator. Compounds 2 and 3 exhibited significant anti-inflammatory activity by inhibiting the production of PGE2 in plasma samples, thus by interference with the cyclooxygenase (COX) inflammatory pathway. Therefore, these findings demonstrate that the bicyclic octane neolignan classes [3.2.1] can present anti-inflammatory potential.
RESUMEN
A partir de um estudo sobre a anatomia foliar de Aniba firmula (Nees & C. Mart.) Mez (Lauraceae), objetivou-se identificar caracteres anatômicos que possam auxiliar, de forma efetiva, sua morfodiagnose, tendo em vista que as espécies pertencentes a esse gênero são consideradas de difícil identificação devido à semelhança entre elas. Para realização do trabalho, foram utilizados métodos usuais em Anatomia Vegetal. Os resultados revelaram caracteres que podem ser considerados diagnósticos para a espécie, tais como: presença de tricomas tectores; estômatos paracíticos classificados como sendo do tipo "graminoide"; cristais prismáticos em células parênquimáticas no pecíolo; tricoesclereídes e braquiesclereides na lâmina foliar; sistema vascular em arco, com extremidades voltadas para o centro nas porções proximal e mediana do pecíolo e em arco com extremidades eretas na porção distal; sistema vascular na forma de arco com extremidades eretas, "V" aberto ou traço contínuo na nervura mediana; células oleíferas no mesofilo; padrão de venação camptódromo-broquidódromo, com venação marginal do tipo fimbrial. A análise de indivíduos ocorrentes em diferentes localidades foi determinante para a escolha de caracteres que não variam em decorrência das condições ambientais distintas.
The study about the leaf anatomy of Aniba firmula (Nees & C. Mart.) Mez (Lauraceae), aimed to identify anatomical characters that assists in its diagnosis, in view of the difficulty to identificate the Aniba species by being considered very similars. To realizate this research, usual methods in Plant Anatomy were applied. The obtained results considered like diagnostic characters were the presence of non glandular trichomes; paracitic stomata like "graminoid type"; prismatic crystals in parenchymatic cells, trichosclereids and brachisclereids; vascular system in arc form, with borders revolved to the center in the basal and middle region and "U" shaped in distal region of the petiole, midrib in "U" or "V" shaped or simple trace form; oil cells in the mesophyll and camptodromous-broquidodromous venation pattern with fimbrial margin. The analysis of specimens occuring in different towns was crucial to choose the characters that´s not change because of the different environmental conditions.