Quantification of genetic variability and stable genotype selection over the years in the germplasm of critically endangered Prishanparni (Uraria picta Desv.).

Prishanparni (Uraria picta Desv.), a critically endangered annual shrub belonging to the family 'Papillionaceae'. It is widely distributed throughout India, Sri Lanka, Bangladesh, Tropical Africa, Malay Islands, and the Philippines. The consistent performances of U. picta accessions based on ten economic traits studied were identified as P-12, P-16, P-21, P-22, P-31, P-47, and P-48. These accessions could be used for commercial cultivation in northern Indian plains. Among the total twenty-three studied accessions P-50, P-21, P-48, and P-47 were found superior for rhoifolin content in their aerial as well as root part, which may have various therapeutic potentials used in traditional and modern systems of medicines. These accessions can be exploited for commercial cultivation or in a hybridization program for further crop improvement. Wide range cultivation of the selected accessions in the Indo-Gangetic plains will fit in the existing cropping systems of this region, resulting in comparatively better supplementation of herb to the pharmaceutical and herbal drug industries and reducing the pressure on the wild populations.

Efficacy of Dashmool Vasti as an adjuvant therapy with the standard of care (modern + physiotherapy) in the rehabilitation of stroke as compared to standard of care - a clinical trial protocol.

Background: Stroke is ischemia and neurological dysfunction caused by acute brain circulation loss. It causes acute localized neurological abnormalities such as weakness, sensory deficit, or language issues that require long-term treatment. These deficiencies harm the patient and their family psychologically, socially, and economically. Thus, combination treatment can rapidly rehabilitate such patients. Detoxification methods like Ayurvedic medicated enema help stroke pathophysiology. Physical modalities in physiotherapy have been shown to facilitate normal movement and function on the stroke patient's affected side, increasing independence with everyday duties. A stroke patient may benefit from Dashmoola Niruha Basti, Function Electrical Stimulation (FES), and Motor Relearning Programme (MRP). Aim & Objectives: This study compares the adjuvant role of Dashmoola Basti with MRP and FES in stroke recovery. The main goals of this study are to assess and compare the adjuvant role of Dashmoola Basti with standard control over sensorimotor function of lower extremities, static and dynamic balance in stroke patients; gait parameters; resistance experienced during passive range of motion; quality of life of patients; Barthel Index; Modified Ashworth Scale; and Fuglmeyer assessment, Single Limb Stance Test, Functional Reach Test. Methods: A total of 40 patients will be enrolled and divided randomly into two equal groups. In Group A (control), standard treatment (modern + physiotherapy) will be prescribed for one month. In Group B (interventional group), Dashmoola Basti will be added to the aforementioned standard treatment for one month. Expected results: Improvement in Fuglmeyer assessment, Single Limb Stance Test, Functional Reach Test, quality of Life of Patients, Barthel Index, Modified Ashworth scale, and National Institute of Health (NIH) stroke-scale-score will be observed and recorded. Conclusions: Results and conclusions will be derived according to the data collected in case record form and assessment sheets filled at baseline and follow-up visits. Trial registration: CTRI/2021/10/037445 dated 21.10.2021.