Accumulation of antibiotics in the environment: Have appropriate measures been taken to protect Canadian human and ecological health?

In Canada, every day, contaminants of emerging concern (CEC) are discharged from waste treatment facilities into freshwaters. CECs such as pharmaceutical active compounds (PhACs), personal care products (PCPs), per- and polyfluoroalkyl substances (PFAS), and microplastics are legally discharged from sewage treatment plants (STPs), water reclamation plants (WRPs), hospital wastewater treatment plants (HWWTPs), or other forms of wastewater treatment facilities (WWTFs). In 2006, the Government of Canada established the Chemicals Management Plan (CMP) to classify chemicals based on a risk-priority assessment, which ranked many CECs such as PhACs as being of low urgency, therefore permitting these substances to continue being released into the environment at unmonitored rates. The problem with ranking PhACs as a low priority is that CMP's risk management assessment overlooks the long-term environmental and synergistic effects of PhAC accumulation, such as the long-term risk of antibiotic CEC accumulation in the spread of antibiotic resistance genes. The goal of this review is to specifically investigate antibiotic CEC accumulation and associated environmental risks to human and environmental health, as well as to determine whether appropriate legislative strategies are in place within Canada's governance framework. In this research, secondary data on antibiotic CEC levels in Canadian and international wastewaters, their potential to promote antibiotic-resistant residues, associated environmental short- and long-term risks, and synergistic effects were all considered. Unlike similar past reviews, this review employed an interdisciplinary approach to propose new strategies from the perspectives of science, engineering, and law.

Evaluation of Reduced Fungicide Applications for Disease Management in Cold-Climate Wine Grapes in Wisconsin.

Cold-climate wine grapes are produced on 8,000 ha in the North Central region of the United States. Wisconsin has experienced considerable growth, with a 26% increase in acreage since 2017. Chemical management of fungal diseases in cold-climate, interspecific hybrid grapes mirrors that of traditional Vitis vinifera cultivars despite significant differences in disease susceptibility. Most cold-climate cultivars display disease tolerance or resistance to key pathogens such as Plasmopara viticola (downy mildew), Erysiphe necator (powdery mildew), and Phyllosticta ampelicida (black rot). Current fungicide programs in Wisconsin's cold-climate grape industry underutilize genetic resistance, resulting in overreliance on at-risk fungicides and an increased threat of fungicide resistance development. In vineyard trials, the impacts of a reduced fungicide application number compared to current grower "Standard" programs was assessed for disease incidence and severity for five diseases: anthracnose, black rot, downy mildew, Phomopsis cane and leaf spot and powdery mildew. In 2022, with moderate disease pressure at both vineyard sites, there were no significant differences observed when fewer fungicides (six or five applications vs. four applications) were applied. In 2023, higher disease incidence was observed in the "Standard" spray program at one study location which received a greater number of fungicide applications. In both years, grape cultivar was a significant factor with the 'LaCrosse' displaying greater average disease severity than the 'St. Pepin' in both the "Standard" and "Reduced" Programs. These findings present a promising opportunity for cold-climate grape growers to reduce the number of fungicide applications while maintaining disease control and marketable yield.

Coupled Dynamic Material Flow, Multimedia Environmental Model, and Ecological Risk Analysis for Chemical Management: A Di(2-ethylhexhyl) Phthalate Case in China.

Di(2-ethylhexhyl) phthalate (DEHP) is a widely used plasticizer that has adverse effects on ecosystems and human health. However, data about its stocks, flows, emission rates, as well as ecological risks are generally unknown in China, one of the world's largest producers of chemicals including DEHP, limiting sound management of chemicals. Herein, dynamic material flow analysis, coupled with a multimedia environmental model and ecological risk analysis, was performed to fill the data gap about DEHP in China mainland from 1956 to 2020. Results indicate that the in-use stocks of DEHP increased from 6.54 × 106 kg in 1956 to 8.40 × 109 kg in 2020. With growth in the emission rates, DEHP concentrations in air, soil, water, and sediment kept increasing from 1956 to 2010, which declined after 2010 and regrew after 2015. Sediment was a main sink of DEHP with the highest ecological risk quotient of >10 after 1999, necessitating measures for controlling the risk, for example, technology innovation to reduce DEHP emission rates, and substitution of DEHP with low-toxic alternatives. The coupled models that connect socio-economic data with ecological risk output may provide a systematic methodology for verification of the data necessary for risk control of chemicals.

Identification and Management of Phytophthora Aerial Blight Caused by Phytophthora nicotianae on Catharanthus roseus.

Phytophthora nicotianae is the most common pathogen in nurseries and gardens, infecting both woody and herbaceous ornamental plants. Phytophthora aerial blight symptoms such dull water-soaked lesions on shoot tips and leaf petioles, girdling on the main stem, necrosis, and wilting of annual vinca were observed in a commercial greenhouse in Warren County, TN, U.S.A., in May 2016. The objective of this study was to identify the causal agent of Phytophthora aerial blight and develop a fungicide management recommendation for ornamental producers. Attempts to isolate the pathogen from symptomatic leaf tissue were conducted, and excised leaf pieces were embedded in V8 agar medium. Morphological characterization, PCR, sequencing, and pathogenicity test of the isolate FBG2016_444 were conducted to confirm the pathogen identification. The sequence identity was 100% identical to P. nicotianae, and a combined phylogenetic tree (internal transcribed spacer, large subunit of rDNA, and ras-related protein gene) grouped isolate FBG2016_444 within the clade of P. nicotianae. In the pathogenicity study, all inoculated annual vinca plant showed Phytophthora aerial blight symptoms, and P. nicotianae was reisolated, whereas noninoculated annual vinca plant remained symptomless. These findings confirmed P. nicotianae as the causal agent of Phytophthora aerial blight of annual vinca. In addition, two rates (0.078 and 0.156 ml·liter-1) and three application intervals (7, 14, and 21 days before inoculation [DBI]) of oxathiapiprolin (Segovis) were evaluated for their ability to reduce the Phytophthora aerial blight severity on annual vinca plants. The control groups were positive (nontreated inoculated) and negative (nontreated noninoculated) plants. Both rates and application timings of oxathiapiprolin significantly reduced Phytophthora aerial blight severity and disease progress (area under disease progress curve [AUDPC]) on annual vinca plants compared with the positive control. However, 0.078 and 0.156 ml·liter-1 of oxathiapiprolin applied at 7 or 14 DBI were the most effective treatments in reducing the disease severity and AUDPC on annual vinca plants. The plant growth parameters such as increase in height and width, total plant weight, and root weight were not influenced by the application of oxathiapiprolin. The findings reported in this study will help ornamental producers with better management of Phytophthora aerial blight of annual vinca.

Impact of Foliar Application of Acibenzolar-S-Methyl on Rose Rosette Disease and Rose Plant Quality.

Rose rosette disease (RRD) caused by rose rosette emaravirus (RRV) is a major issue in the U.S. rose industry with no effective method for its management. This study evaluated the effect of foliar application of acibenzolar-S-methyl (ASM), a plant systemic acquired resistance inducer, in reducing RRD disease severity on Rosa species cv. Radtkopink ('Pink Double Knock Out') under greenhouse conditions, and the effect of ASM on plant growth under commercial nursery production conditions. ASM at 50- or 100-mg/liter concentrations at weekly intervals significantly reduced RRD severity compared with the untreated control in two of the three greenhouse trials (P < 0.05). The plants in these trials were subsequently pruned and observed for symptoms, which further indicated that application of ASM at 50- or 100-mg/liter concentrations lowered disease severity compared with the untreated control (P < 0.05) in these two trials. Plants treated with ASM at 50- or 100-mg/liter concentrations had delayed incidence of RRD compared with the nontreated controls. Plants treated with ASM at the 50- or 100-mg/liter rate in all three trials either did not have RRV present or the virus was present in fewer leaf samples than untreated controls as indicated by quantitative reverse transcription PCR analysis. Overall, plants treated with ASM at the 50-mg/liter concentration had 36 to 43% reduced RRD incidence compared with the water control. The treatment of two cultivars of rose, 'Radtkopink' and 'Meijocos' ('Pink Drift'), with weekly foliar applications of ASM at the three rates (0.5, 0.75, and 1.0 oz/A) indicated that ASM had no negative effect on flowering or plant growth at even the highest rate of application.

The Bioactivity and Efficacy of Benzovindiflupyr Against Corynespora cassiicola, the Causal Agent of Cucumber Corynespora Leaf Spot.

Corynespora cassiicola, which causes Corynespora leaf spot, results in considerable yield loss of cucumber grown in greenhouses. Frequent reports of reduced efficacy and control failure of fungicides warrant new, efficient alternative chemistries. In this study, the sensitivity of C. cassiicola to benzovindiflupyr was evaluated using a collection of 81 isolates collected from Shandong, China. The mean EC50 values for mycelial growth, spore germination, and germ tube elongation of C. cassiicola were 0.69 ± 0.44, 0.12 ± 0.063, and 0.13 ± 0.076 µg ml-1, respectively. Benzovindiflupyr treatment led to a reduced respiration rate and ATP production of C. cassiicola and decreased spore pathogenicity by 21.9% on average. Additionally, detached cucumber leaves sprayed with fungicides before or after inoculation were used to assess the efficacy of benzovindiflupyr against C. cassiicola. Benzovindiflupyr (150 µg ml-1) exhibited preventive and curative efficacies of 86.9 and 77.1%, respectively. Benzovindiflupyr at 150 g a.i. ha-1 provided over 70% efficacy in field trials performed in 2018 and 2019, which was significantly higher than that of the reference fungicides fluopyram and fluxapyroxad at the same dose. Furthermore, the yield of commercial cucumber increased as disease incidence decreased. Our findings pave the way for the introduction of benzovindiflupyr in the integrated management of Corynespora leaf spot.

Effects of Peroxyacetic Acid on Postharvest Diseases and Quality of Blueberries.

Postharvest diseases are a limiting factor in the storage of fresh blueberries. Gray mold caused by Botrytis cinerea and Alternaria rot caused by Alternaria spp. are important postharvest diseases in blueberries grown in California. Control of these fungal pathogens is generally dependent on preharvest sprays of synthetic fungicides, but in California multiple fungicide resistance has already developed in those pathogens, leading to the failure of disease control. Therefore, alternatives to synthetic fungicides are needed for the control of postharvest diseases. Peroxyacetic acid (PAA) is a disinfectant agent that poses low risk to human health. In this study, we evaluated the effects of postharvest use of PAA at 24 µl liter-1 and 85 µl liter-1 on fruit decay caused by fungal pathogens and quality of stored blueberry fruit. PAA treatment was applied to four cultivars over three seasons using two methods, dipping or spraying. Dipping blueberries compared with spraying them with PAA and its application at 85 µl liter-1 were the most effective treatments. For example, when applied to 'Snowchaser' blueberries, this combination reduced naturally occurring decay after 4 weeks of storage at 0 to 1°C from 14.3% among water-treated controls to 2.7% in 2018, and from 25.7% among water-treated controls to 8.6% in 2020. In general, PAA did not adversely affect fruit quality or sensory quality of blueberries. Postharvest use of PAA appears to be a promising means to reduce postharvest decay of blueberries. To reliably obtain an acceptable level of disease control, the best use of PAA may be in combination with other practices rather than using it alone.

POPs identification using simple low-code machine learning.

Effectively identifying persistent organic pollutants (POPs) with extensive organic chemical datasets poses a formidable challenge but is of utmost importance. Leveraging machine learning techniques can enhance this process, but previous models often demanded advanced programming skills and high-end computing resources. In this study, we harnessed the simplicity of PyCaret, a Python-based package, to construct machine-learning models for POP screening based on 2D molecular descriptors. We compared the performance of these models against a deep convolutional neural network (DCNN) model. Utilising minimal Python code, we generated several models that exhibited superior or comparable performance to the DCNN. The most outstanding performer, the Light Gradient Boosting Machine (LGBM), achieved an accuracy of 96.20 %, an AUC of 97.70 %, and an F1 score of 82.58 %. This model outshone the DCNN model. Furthermore, it excelled in identifying POPs within the REACH PBT and compiled industrial chemical lists. Our findings highlight the accessibility and simplicity of PyCaret, requiring only a few lines of code, rendering it suitable for non-computing professionals in environmental sciences. The ability of low code machine learning tools (e.g. PyCaret) to facilitate model comparison and interpretation holds promise, encouraging prompt assessment and management of chemical substances.

Incorporating climate change model projections into ecological risk assessments to help inform risk management and adaptation strategies: Synthesis of a SETAC Pellston Workshop®.

The impacts of global climate change are not yet well integrated with the estimates of the impacts of chemicals on the environment. This is evidenced by the lack of consideration in national or international reports that evaluate the impacts of climate change and chemicals on ecosystems and the relatively few peer-reviewed publications that have focused on this interaction. In response, a 2011 Pellston Workshop® was held on this issue and resulted in seven publications in Environmental Toxicology and Chemistry. Yet, these publications did not move the field toward climate change and chemicals as important factors together in research or policy-making. Here, we summarize the outcomes of a second Pellston Workshop® on this topic held in 2022 that included climate scientists, environmental toxicologists, chemists, and ecological risk assessors from 14 countries and various sectors. Participants were charged with assessing where climate models can be applied to evaluating potential exposure and ecological effects at geographical and temporal scales suitable for ecological risk assessment, and thereby be incorporated into adaptive risk management strategies. We highlight results from the workshop's five publications included in the special series "Incorporating Global Climate Change into Ecological Risk Assessments: Strategies, Methods and Examples." We end this summary with the overall conclusions and recommendations from participants. Integr Environ Assess Manag 2024;20:359-366. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

Diversity of fungal pathogens in leaf spot disease of Indian mulberry and its management.

Leaf spot disease in mulberry significantly affects silk production by reducing the nutritive quality of the leaves. This disease caused by various pathogens, regardless of the localities under the same climatic region. In the present investigation, an approximate incidence rate of 84 % was recorded in Karnataka based on surveys conducted in both farmer fields and germplasm locations. The causative agents have shown diversification, including new candidates such as Bipolaris sorokiniana, Curvularia lunata, Cladosporium sphaerospermum, and Epicoccum sorghinum. These findings mark the first report of these pathogens in Indian mulberry production. The investigation involved detailed pathogenicity assessments on the predominant mulberry silk production cultivar under controlled and field environments. Pathogens were identified using morpho-cultural, microscopic and phylogenetic analyses, including the internal transcribed spacer (ITS). Various concentrations of fungicides, both individually and in combinations, were evaluated to identify effective measures for mitigating yield losses. Among the fungicides tested against the new pathogens, Hexaconazole 5 % SC and Hexaconazole 5 % + Captan 70 % WP demonstrated high promise and cost-effectiveness. Consequently, these fungicides could serve as immediate solutions to prevent further yield reduction. However, it is essential to conduct comprehensive field investigations before recommending them as standard practices. Future research endeavors should focus on assessing the extent of crop loss caused by these newly identified pathogens in mulberry cultivation.

Long-term trend data for PFAS in soils from German ecosystems, including TOP assay.

In this study, soil top layers from the German Environmental Specimen Bank (ESB) covering a period from 2002 to 2018 and 11 sampling sites representing four ecosystem types were analysed for 24 PFAS (11 PFCA, 7 PFSA, and 6 precursors), including the total oxidizable precursor (TOP) assay. Median ΣPFAS levels before and after TOP assay ranged from 0.31 to 19.7 µg/kg dry weight (dw) and 0.32 to 20.4 µg/kg dw, respectively. The most frequently measured PFAS above LOQ were PFOS and PFOA, which were present at concentrations above 0.1 µg/kg dw in each sample. Both accounted, on average, for half to two-thirds of the total identified PFAS load at most sites. The investigated samples from the near-natural and forestry ecosystem types each had significantly higher PFAS levels than those from the urban-industrial ecosystem type, while samples from the agricultural ecosystem type did not differ distinctly from the others. Increases of median ΣPFAS levels after TOP assay ranged up to slightly >20 %, indicating that precursor compounds do not play a major role in the substance spectrum of German ESB soil samples from different ecosystem types. Total organic carbon (TOC) content in analysed samples ranged from about 1 % in sandy soil to >40 % in litter layer and showed a strong positive correlation with PFAS concentrations. It is therefore highly recommended that TOC content is reported along with PFAS levels in soils. PFAS trend analysis for nine sampling sites before and after TOP assay showed that concentration levels at most sites have remained more or less stable for the sampled period of almost two decades. The constant PFAS levels in soil samples indicate that PFOS and PFOA regulations have not yet had a positive effect on the exposure situation in this environmental compartment.

Herbicides reduce the severity and sporulation of Phakopsora pachyrhizi in soybean with triple herbicide resistance.

BACKGROUND: Transgenic event DAS44406-6 (E3) makes soybeans that are herbicide [glyphosate (Gly), 2,4-dichlorophenoxyacetic acid (2,4-D) and glufosinate] and caterpillar resistant. The E3 soybean was commercially released for the 2021/2022 harvest in Brazil. We conducted this study to test whether Gly and 2,4-D applied alone and in a commercial mixture affect Asian soybean rust (ASR). Assays were conducted in detached leaves and in vivo, in a controlled environment using the herbicides Gly, 2,4-D and Gly + 2,4-D, and pathogen inoculation. Disease severity and spore production were evaluated. RESULTS: Only the herbicides Gly and Gly + 2,4-D inhibited ASR in detached leaves and in vivo. When applied preventively and curatively in vivo, these herbicides reduced the disease severity and spore production of the fungus. In vivo, inhibition of disease severity reached 87% for Gly + 2,4-D and 42% for Gly. A synergistic effect was observed with the commercial Gly + 2,4-D mixture. Application of 2,4-D alone in the in vivo assays did not reduce or increase disease severity. Gly and Gly + 2,4-D act residually in inhibiting the disease. Growing E3 soybeans may combine weed and caterpillar management benefits with ASR inhibition. CONCLUSION: Application of Gly and Gly + 2,4-D herbicides in resistant E3 soybean shows inhibitory activity for ASR. © 2023 Society of Chemical Industry.

Advancing the weight of evidence approach to enable chemical environmental risk assessment for decision-making and achieving protection goals.

The weight of evidence (WoE) approach conflates the aspects of quality, reliability, relevance, and consistency of data and information to systematically strengthen the body of evidence and enable credible communication and decision-making on chemical risk assessment. Between 2015 and 2019, the Society of Environmental Toxicology and Chemistry (SETAC) held several workshops in all the geographical units with scientists and managers from academia, government, and business sectors focusing on the chemical risk-assessment approach. This article summarizes the knowledge that informs the needs concerning application of WoE, especially in the context of developing countries. This effort supports the use of existing data and test strategies for assessing chemical toxicity, exposure, and risk, and highlights the critical process for risk assessors to convey and discuss information sufficiency and uncertainty mitigation strategy with risk managers. This article complements the four articles in the special series that provide a critical review of existing frameworks for chemical risk screening and management, and applications of the WoE approach for assessing exposure in the aquatic environment, prediction of fish toxicity, and bioaccumulation. Collectively, the articles exemplify the use of WoE approaches to evaluate chemicals that are data rich and/or data poor for decision-making. They integrate the WoE concepts and approaches into practical considerations and guidance, and help to scale the value of WoE in supporting sound chemical risk assessment and science-based policy implementation. Integr Environ Assess Manag 2023;19:1188-1191. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

[Research Status and Trend Analysis of Environmental and Health Risk and Control of Persistent, Mobile, and Toxic Chemicals].

Persistent, mobile, and toxic or very persistent and very mobile (PMT/vPvM) chemicals have been widely detected in surface water, groundwater, and drinking water around the world and are important emerging contaminants that may significantly affect human health and the environment in the future. According to the identification criteria proposed by the European Union, there are thousands of PMT/vPvM substances in existing chemicals, covering a wide range of applications, including dozens of high-yield industrial chemicals such as melamine. PMT/vPvM chemicals can be discharged into the environment through farmland runoff, industrial wastewater, and domestic sewage, and sewage treatment plants are currently considered to be their main discharge route. It is difficult to effectively remove PMT/vPvM chemicals through the current conventional water treatment technology; they can exist in the water circulation system of the urban human settlement environment for a long time, endangering the safety of drinking water and the ecosystem. The European Union has taken the lead in introducing PMT/vPvM chemicals specifically into the priority areas of the current chemical risk management system. At present, there are still many potential PMT/vPvM chemicals in the environment, and their monitoring methods need to be further improved. It will take time for the identification of substances, the scope of categories, and the establishment of lists. Studies on the environmental fate and exposure of PMT/vPvM in various regions of the world are still very limited, and research on the potential, long-term ecotoxicity, and human health hazard effects remains scarce. At the same time, the research and development of substitute or alternative technologies, as well as environmental engineering treatment technologies such as sewage treatment and contaminated site remediation, will become an urgent need for future PMT/vPvM risk scientific research and management decisions.

Alternative Chemical Control Options and Monitoring Techniques for Triops longicaudatus (Notostraca: Triopsidae) in California Rice.

The tadpole shrimp (Triops longicaudatus (Leconte); Notostraca; Triopsidae) is a vernal pool crustacean that has emerged as a significant pest for many rice farmers in California. Currently, lambda-cyhalothrin is the commercial standard and sole management practice for TPS, but resistance appears to be emerging. Field and laboratory trials were conducted from 2015 to 2018 at the Rice Experiment Station in Biggs, California, and in greenhouses at the University of California (UC) Davis to evaluate the efficacy of several alternative chemical controls and to explore early indicators of TPS activity and damage as monitoring tools. TPS mortality in plots treated with azadirachtin was not significantly different from those in the untreated control across all trials. Copper sulfate, lambda-cyhalothrin, and clothianidin were consistently effective across both lab and field trials. Chlorantraniliprole generated effective control in four of the five trials, whereas two diflubenzuron rates generated adequate control in the field, but not in laboratory bioassays. Thus, there appear to be several effective alternative control options available for farmers, should resistance to lambda-cyhalothrin continue to spread. Water turbidity (measured using a scale of 1-4) and the number of dislodged seedlings were both significantly correlated with TPS counts in field studies. Turbidity exhibited the highest correlations with TPS counts, suggesting that with further refinement it could play a valuable role in monitoring TPS populations.

Unlocking India's Potential in Managing Endocrine-Disrupting Chemicals (EDCs): Importance, Challenges, and Opportunities.

Endocrine-disrupting chemicals (EDCs) are a prime concern for the environment and health globally. Research shows that in developing countries such as India both the environment and human populations are severely exposed to EDCs and consequently experience rising incidents of adverse health effects such as diabetes and cancers. In this paper, we discuss the current EDC management approach in India, critically assess its limitations, and describe opportunities for potential improvements. Foremost, current EDC management actions and interventions in India are fragmented and outdated, and far behind the modern and comprehensive approaches adopted in the European Union and other developed countries. Strong and well-planned actions are required on various fronts of science, policy, commerce, and public engagement. These actions include the adoption of a dedicated and modern regulatory framework for managing EDCs, enhancing capacity and infrastructure for EDC monitoring in the environment and human population, employing public-private partnership programs for not only managing EDCs but also in the sectors that indirectly contribute toward the mismanagement of EDCs in the country, and raising awareness on EDCs and promoting health-preserving consumption habits among the public. As India hosts a large proportion of the global human population and biodiversity, the success or failure of its actions will substantially affect the direction of global efforts to manage EDCs and set an example for other developing countries.

An all-in-one tool for multipurpose ecological risk assessment and management (MeRAM) of chemical substances in aquatic environment.

A quality-assured ecological risk assessment (ERA) requires enormous resources (time and labor) in collection/assessment of hazard data, as well as considerable expertise to interpret the risk. The ERA of chemicals is thereby considered difficult or impossible for those with little assessment experience and cumbersome or complicated for practitioners. To meet the concerns regarding ERA and accelerate the risk assessment and management of chemicals, we developed an all-in-one free tool for multi-purpose ecological risk assessment management (MeRAM) of chemical substances in aquatic environment called the AIST-MeRAM Ver. 2.0.0 (Copyright No: H28PRO-2007). It allows users from beginners to experts to conduct ERA without any preparation because all the necessary ecotoxicity test data and methodologies are available in the system. Approximately 270,000 ecotoxicity test data points for 3900 chemical substances together with the scientific methodologies from traditional simple hazard quotient (HQ) to more ecologically relevant complicated assessments such as species sensitivity distribution (SSD) and population-level assessment are embedded in the AIST-MeRAM. In addition, users can easily understand the Japanese regulatory RA and management of chemical substances due to a special function based on the Japanese Chemical Substance Control Law (CSCL). Here, we demonstrate a tiered ERA using the embedded sample data to evaluate and ensure the functions of AIST-MERAM. We show that the AIST-MeRAM can provide a comprehensive and accurate ERA, suggesting that it is a powerful IT solution for cumbersome ERA.

Transition of chemical management in Japan -Shift to self-regulation and measures for small businesses.

Increased variety and use of chemicals and the number of chemical disasters have changed chemical management. Europe and the United States have adopted self-regulation in chemical management; furthermore, countries worldwide must comply with the relevant United Nations recommendations and international standards for chemical management. Japan has experienced numerous pollution incidents and occupational disasters, resulting in the development of laws and regulations on chemical management; however, these policies are inconsistent with international trends. In particular, the shift from a compliance approach to self-regulation and measures for small businesses remain as challenges. This paper discusses the current situation and issues in chemical management in Japan, focusing on international trends.

Current trends and future prospects of chemical management of oral biofilms.

Oral biofilm, a tribulation encountered on a general basis is known to associate and contribute to many oral and systemic diseases. Eradication of these biofilms is a primary step in treatment of the underlying malady. Management of a biofilm is governed by various factors: the microenvironment within a biofilm, bond between the adhered surface and the biofilm, location of the biofilm, access to the biofilm for removal. Though annihilation is the priority, the mode of approach to achieve the same is equally important, because biofilm's heterogenic nature and location govern the strategical treatment required. Literature supports that the consequences of oral biofilms is not restricted to its home ground, but disseminated to other systems of the body. This contemplates us to procure knowledge on its development, structure and progression to aim its eradication. Therefore, this review attempts to recognize the type of biofilm based on location and enumerate all the possible chemical modes of management for the specific type of oral biofilms encountered. In addition, to the traditional strategies prescribed or administered, newer approaches which are gaining popularity due to their ease and efficiency are also addressed. Frontiers in the above field, under investigation and promising in near future are also compiled. Thus, the present review aims to provide a comprehensive elucidation of chemical management of oral biofilms, both the conventional and novel approaches under investigation.

Implementation of green chemistry principles in circular economy system towards sustainable development goals: Challenges and perspectives.

Green chemistry principles (GCP) are comprehensively deployed in industrial management, governmental policy, educational practice, and technology development around the world. Circular economy always aims to balance the economic growth, resource sustainability, and environmental protection. This article offers a highlight on issues of significance within GCP and circular economy, and proposes the integrated strategies for GCP implementation from the aspects of governance, industry and education. At first, we developed a new categorizing system for GCP dividing to (i) pollution and accident prevention, (ii) safety and resource sustainability, and (iii) energy and resource sustainability. To assess the GCP practice towards the circular economy, the implementation of international movement of GCP in worldwide policy, especially those of Canada, China, Germany, Japan, South Korea, Sweden, Taiwan, United States and United Kingdom were reviewed. The policy implementation of GCP practices among governance, industries and education was analyzed. To integrate GCP into the circular economy concept, we also proposed five strategies of priority governance direction as follows: (i) establishment of cross-departmental collaboration, (ii) development of cleaner production and green product, (iii) provision of integrated chemical management system, (iv) implementation of green chemistry education program, and (v) construction of a business model. Finally, we discussed the prospects of disciplinary elements including the establishment of redesign-reduction-recovery-recycle-reuse (5R) practices for wastes reclamation, deployment of water-energy-food nexus with GCP to improve the food security and resource sustainability, and implementation of GCP in the green smart industrial park.