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1.
Memory ; 32(2): 264-282, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38315731

RESUMEN

Flashbulb memories (FBMs) refer to vivid and long-lasting autobiographical memories for the circumstances in which people learned of a shocking and consequential public event. A cross-national study across eleven countries aimed to investigate FBM formation following the first COVID-19 case news in each country and test the effect of pandemic-related variables on FBM. Participants had detailed memories of the date and others present when they heard the news, and had partially detailed memories of the place, activity, and news source. China had the highest FBM specificity. All countries considered the COVID-19 emergency as highly significant at both the individual and global level. The Classification and Regression Tree Analysis revealed that FBM specificity might be influenced by participants' age, subjective severity (assessment of COVID-19 impact in each country and relative to others), residing in an area with stringent COVID-19 protection measures, and expecting the pandemic effects. Hierarchical regression models demonstrated that age and subjective severity negatively predicted FBM specificity, whereas sex, pandemic impact expectedness, and rehearsal showed positive associations in the total sample. Subjective severity negatively affected FBM specificity in Turkey, whereas pandemic impact expectedness positively influenced FBM specificity in China and negatively in Denmark.


Asunto(s)
COVID-19 , Memoria Episódica , Humanos , Emociones , China , Turquía , Recuerdo Mental
2.
Proc Natl Acad Sci U S A ; 118(35)2021 08 31.
Artículo en Inglés | MEDLINE | ID: mdl-34426492

RESUMEN

Humans are social animals, but not everyone will be mindful of others to the same extent. Individual differences have been found, but would social mindfulness also be shaped by one's location in the world? Expecting cross-national differences to exist, we examined if and how social mindfulness differs across countries. At little to no material cost, social mindfulness typically entails small acts of attention or kindness. Even though fairly common, such low-cost cooperation has received little empirical attention. Measuring social mindfulness across 31 samples from industrialized countries and regions (n = 8,354), we found considerable variation. Among selected country-level variables, greater social mindfulness was most strongly associated with countries' better general performance on environmental protection. Together, our findings contribute to the literature on prosociality by targeting the kind of everyday cooperation that is more focused on communicating benevolence than on providing material benefits.


Asunto(s)
Atención Plena , Conducta Social , Adolescente , Adulto , Conservación de los Recursos Naturales , Conducta Cooperativa , Características Culturales , Femenino , Humanos , Internacionalidad , Masculino , Adulto Joven
3.
Risk Anal ; 44(3): 521-535, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-37350030

RESUMEN

Microplastics are receiving growing attention in the public debate, while the scientific assessment of risks of microplastics to ecological and human health is still ongoing. Previous studies suggest concerns among the general public with country-specific differences. However, little is known about the reasoning underlying these concerns. By conducting qualitative interviews with German (n = 15) and Italian citizens (n = 15), this study adopted a cross-national perspective to investigate which concepts shape citizens' perceptions of microplastics. A qualitative content analysis was used, with coding categories and subcategories developed inductively. Results showed that interviewees formed assumptions around microplastics despite own uncertainties, transferred knowledge from macro- to microplastics, and used the concepts of accumulation and dose-response relationship to make sense of the topic. Moreover, they saw the domains of human health and the environment as intertwined and expressed helplessness when discussing solutions to the microplastics issue. Many themes on the topic were similar in both samples, but there were also some differences. For instance, whereas Italian participants talked about marine-related microplastics, German participants talked about airborne sources; also, German participants tended to recognize more strongly the actions their country was putting in place to address the problem. These findings underscore the need for proactive risk communication despite remaining gaps in scientific risk assessment. Beyond providing technical information, communicators should consider the reasoning behind risk perception on microplastics and address scientific uncertainty as well as the interconnectedness between the domains of human health and the environment.


Asunto(s)
Microplásticos , Plásticos , Humanos , Comunicación , Investigación Cualitativa , Italia
4.
Alzheimers Dement ; 20(1): 16-24, 2024 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-37490296

RESUMEN

INTRODUCTION: We compared gender disparities in later-life memory, overall and by education, in India and the United States (US). METHODS: Data (N = 7443) were from harmonized cognitive assessment protocols (HCAPs) in the Longitudinal Aging Study of India-Diagnostic Assessment of Dementia (LASI-DAD; N = 4096; 2017-19) and US Health and Retirement Study HCAP (HRS-HCAP; N = 3347; 2016-17). We derived harmonized memory factors from each study using confirmatory factor analysis. We used multivariable-adjusted linear regression to compare gender disparities in memory function between countries, overall and by education. RESULTS: In the United States, older women had better memory than older men (0.28 SD-unit difference; 95% CI: 0.22, 0.35). In India, older women had worse memory than older men (-0.15 SD-unit difference; 95% CI: -0.20, -0.10), which attenuated with increasing education and literacy. CONCLUSION: We observed gender disparities in memory in India that were not present in the United States, and which dissipated with education and literacy.


Asunto(s)
Envejecimiento , Cognición , Masculino , Humanos , Femenino , Estados Unidos , Anciano , Envejecimiento/psicología , Escolaridad , Estudios Longitudinales , Recolección de Datos
5.
Alzheimers Dement ; 20(7): 4635-4648, 2024 07.
Artículo en Inglés | MEDLINE | ID: mdl-38805356

RESUMEN

INTRODUCTION: Informant reports are a critical component of dementia diagnoses, but the comparability of informant reports across countries is not well understood. METHODS: We compared the performance of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) using population-representative surveys in the United States (N = 3183), England (N = 1050), and India (N = 4047). RESULTS: Analyses of regression splines and comparisons of model fit showed strong associations between IQCODE and objective cognition at low cognitive functioning in the United States and England; in India, the association was weaker but consistent over the range of cognition. Associations between IQCODE score and informant generation (analysis of variance [ANOVA] p = 0.001), caregiver status (p < 0.001), and years known by the informant (p = 0.015) were different across countries after adjusting for objective cognition. DISCUSSION: In India, the IQCODE was less sensitive to impairments at the lowest levels of cognitive functioning. Country-specific adjustments to IQCODE scoring based on informant characteristics may improve cross-national comparisons. HIGHLIGHTS: Associations between IQCODE and cognitive testing were similar in the United States and England but differed in India. In India, the IQCODE may be less sensitive to impairments among those with low cognition and no education. Informant characteristics may differentially impact informant reports of decline across countries. Adjustments or culturally sensitive adaptations may improve cross-national comparability.


Asunto(s)
Disfunción Cognitiva , Demencia , Humanos , Masculino , Femenino , Demencia/diagnóstico , Demencia/epidemiología , Anciano , Encuestas y Cuestionarios , Disfunción Cognitiva/diagnóstico , Estados Unidos , India , Inglaterra , Envejecimiento Cognitivo/fisiología , Comparación Transcultural , Cuidadores/psicología , Cuidadores/estadística & datos numéricos , Pruebas Neuropsicológicas/estadística & datos numéricos , Anciano de 80 o más Años
6.
Alzheimers Dement ; 20(3): 1933-1943, 2024 03.
Artículo en Inglés | MEDLINE | ID: mdl-38159252

RESUMEN

INTRODUCTION: We conducted a cross-national comparison of the association between main lifetime occupational skills and later-life cognitive function across four economically and socially distinct countries. METHODS: Data were from population-based studies of aging and their Harmonized Cognitive Assessment Protocols (HCAPs) in the US, South Africa, India, and Mexico (N = 10,037; Age range: 50 to 105 years; 2016 to 2020). Main lifetime occupational skill was classified according to the International Standard Classification of Occupations. Weighted, adjusted regression models estimated pooled and country-specific associations between main lifetime occupational skill and later-life general cognitive function in men and women. RESULTS: We observed positive gradients between occupational skill and later-life cognitive function for men and women in the US and Mexico, a positive gradient for women but not men in India, and no association for men or women in South Africa. DISCUSSION: Main lifetime occupations may be a source of later-life cognitive reserve, with cross-national heterogeneity in this association. HIGHLIGHTS: No studies have examined cross-national differences in the association of occupational skill with cognition. We used data from Harmonized Cognitive Assessment Protocols in the US, Mexico, India, and South Africa. The association of occupational skill with cognitive function varies by country and gender.


Asunto(s)
Envejecimiento , Cognición , Masculino , Humanos , Femenino , Estados Unidos/epidemiología , Anciano , Persona de Mediana Edad , Anciano de 80 o más Años , Sudáfrica/epidemiología , México/epidemiología , Envejecimiento/psicología , Ocupaciones
7.
Alzheimers Dement ; 20(3): 2273-2281, 2024 03.
Artículo en Inglés | MEDLINE | ID: mdl-38284801

RESUMEN

The Harmonized Cognitive Assessment Protocol (HCAP) is a major innovation that provides, for the first time, harmonized data for cross-national comparisons of later-life cognitive functions that are sensitive to linguistic, cultural, and educational differences across countries. However, cognitive function does not lend itself to direct comparison across diverse populations without careful consideration of the best practices for such comparisons. This perspective discusses theoretical and methodological considerations and offers a set of recommended best practices for conducting cross-national comparisons of risk factor associations using HCAP data. Because existing and planned HCAP studies provide cognition data representing an estimated 75% of the global population ≥65 years of age, these recommended best practices will support high-quality comparative analyses of cognitive aging around the world. The principles described in this perspective are applicable to any researcher aiming to integrate or compare harmonized data on cognitive outcomes and their risk and protective factors across diverse populations.


Asunto(s)
Cognición , Humanos , Factores de Riesgo
8.
J Environ Manage ; 367: 121851, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39067342

RESUMEN

A significant body of research has documented the profound changes in global atmospheric conditions during the COVID-19 pandemic. However, there is still an inadequate comprehensive comparison and assessment of countries before, during, and after the pandemic. Variations in restriction policies, human behaviors, and national traits lead to significant differences in how restriction policies affect atmospheric pollution. This study focuses on NO2, a pollutant with high temporal sensitivity, and utilizes the Oxford COVID-19 policy stringency index along with demographic information. Through spatial-temporal mapping, we analyzed NO2 emission fluctuations and calculated the emission changes in each country. Drawing from this analysis, we explored the relationships among these factors and found that over the span of 2019-2022, across 193 countries, global NO2 emissions displayed a distinct trajectory: initially decreasing, subsequently rebounding, and eventually fluctuating. Most countries exhibited seasonal variations in NO2 emissions. Additionally, the study uncovered a correlation between the stringency of COVID-19 policies and the reduction in NO2 emissions: as policies became stricter, emissions significantly decreased in most countries. In contrast, in countries with lower population densities, stricter policies paradoxically led to an increase in emissions. These findings underscore the importance of considering demographic factors and geographical context in the formulation and implementation of environmental policies.


Asunto(s)
COVID-19 , Monitoreo del Ambiente , Dióxido de Nitrógeno , Dióxido de Nitrógeno/análisis , Humanos , Monitoreo del Ambiente/métodos , Contaminación del Aire/análisis , Contaminantes Atmosféricos/análisis , SARS-CoV-2 , Tecnología de Sensores Remotos , Pandemias , Política Ambiental
9.
Arch Orthop Trauma Surg ; 144(6): 2731-2743, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38761235

RESUMEN

OBJECTIVE: To describe the disease burden of knee osteoarthritis (KOA) globally, regionally, and in 204 countries by age, sex, and sociodemographic index (SDI) from 1990 to 2019, and to explore cross-national inequalities across SDI. METHODS: The Global Burden of Disease (GBD) 2019 database collected data on KOA worldwide from 1990 to 2019, including prevalence, incidence, years lived with disability (YLDs). The average annual percentage change (AAPC) was used to measure temporal trends. In addition, the inequality slope index and the health concentration index were calculated to quantify the unequal distribution of the burden of KOA across 204 countries worldwide. RESULTS: In 2019, the global age-standardized prevalence rate increased by 7.5% compared with 1990, and the age-standardized incidence rate increased by about 6.2%; The age-standardized YLDs rate increased by about 7.8%. In addition to the Republic of Korea and the United States of America, the disease burden of KOA has increased year by year in other countries around the world. The incidence of KOA was highest at ages 50-59, while the prevalence and rates of YLDs were highest at ages 75-84. The burden of KOA was higher in women than in men. Cross-country inequality suggests that the inequality in the burden of KOA between high SDI and low SDI countries becomes greater, and that countries with high SDI bear a disproportionately high burden. CONCLUSION: The global KOA burden has risen steadily between 1990 and 2019, and cross-national inequality gaps remain large. Targeted measures must therefore be taken to address this inequality and the increasing global KOA disease burden.


Asunto(s)
Carga Global de Enfermedades , Salud Global , Osteoartritis de la Rodilla , Humanos , Osteoartritis de la Rodilla/epidemiología , Masculino , Femenino , Persona de Mediana Edad , Anciano , Salud Global/estadística & datos numéricos , Carga Global de Enfermedades/tendencias , Prevalencia , Anciano de 80 o más Años , Adulto , Incidencia , Costo de Enfermedad , Disparidades en el Estado de Salud , Factores Socioeconómicos
10.
Sci Eng Ethics ; 30(5): 41, 2024 Sep 11.
Artículo en Inglés | MEDLINE | ID: mdl-39259368

RESUMEN

This research explores the perspectives of academic physicists from three national contexts concerning their roles and responsibilities within the realm of science. Using a dataset comprised of 211 interviews with scientists working in China, the United States, and the United Kingdom, the study seeks to explain whether and in what manner physicists conceptualize scientific ethics within a global or national framework. The empirical findings bring to light disparities across nations in the physicists' perceptions of what constitutes responsible mentorship and engagement in public service. These cross-national variations underscore the moral agency of physicists as they navigate the ethical standards embraced by the global scientific community vis-à-vis those that are specific to their respective national contexts. The study's empirical insights may carry significant implications for both policymakers and ethicists, underscoring the imperative of soliciting and acknowledging the perspectives of academic scientists working and living in disparate national contexts when formulating comprehensive science ethics frameworks. Such inclusive and context-aware approaches to shaping ethics in science can contribute to the cultivation of a more robust and universally relevant ethical foundation for the scientific community.


Asunto(s)
Ética en Investigación , China , Humanos , Estados Unidos , Reino Unido , Ciencia/ética , Mentores , Investigadores/ética , Principios Morales , Responsabilidad Social , Actitud , Comparación Transcultural
11.
Soc Sci Res ; 122: 103051, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-39216915

RESUMEN

Women are under-represented in political leadership roles, comprising only a quarter of national parliament members across the world. This is surprising, given women's comparatively high level of education and labor force participation. Why has women's political leadership lagged behind other indicators of gender equality? In this study, we revisit the importance of gender attitudes and examine the extent to which they shape women's share of parliament. Prior studies either examine gender attitudes by relying on cross-sectional research designs with small samples or adopt proxy measures that serve as crude indicators of gender ideology. We overcome these limitations by directly measuring gender attitudes from the World Values Survey and European Values Study, while adopting a panel design with a larger sample of countries and a more comprehensive set of controls. Drawing from our dataset of 275 observations across 101 countries during the 1995-2021 period, we find that our attitudinal measure, gender egalitarianism, wipes away most of the observed differences in women's share of parliament between world regions. Moreover, when we add two-way fixed effects, we find that a one-unit increase in a country's gender egalitarianism score is associated with an increase in women's parliament share by about four or five percentage points. Finally, we address concerns about endogeneity by replicating our results using two-stage least squares models with fixed effects. Overall, our findings suggest that gender ideology helps account for the growing success and persistent obstacles faced by women political candidates across the world.

12.
Soc Sci Res ; 121: 103038, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38871431

RESUMEN

Working time and the environment are two important issues of our time and have attracted wide attention from both academia and the public. An emerging body of literature connects these two fields and discusses the environmental impacts of long working hours, yet little is known about how working time is related to the underlying pro-environmental attitude change. Drawing upon literature in worktime studies and environmental sociology, this study examines the extent to which working hours are associated with environmental concern, and how this relationship is contingent on the level of national economic development and cohort replacement. Cross-national intercohort analyses of four waves of ISSP data show that consistent with the political economic theories and degrowth perspective, working hours are negatively related to environmental concern. Furthermore, this association is more salient in high-income countries and intensifies among younger cohorts. This study highlights the importance of examining environmental concern in a dynamic social structure as well as the possibility of constructing a socio-ecological sustainable society.

13.
Int J Psychol ; 2024 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-39256926

RESUMEN

Research has indicated a link between the moral circle and an individual's prosocial behaviour. However, it remains uncertain whether this relationship holds across a broader range of countries and is influenced by sociocultural contexts. Drawing from an international dataset encompassing 49,540 participants from 57 countries, this study examined the impact of the moral circle on an individual's generosity and the moderating role of cultural religiosity. The results revealed a significant positive association between moral circle and generosity in a cross-national context. Notably, in religious cultures, the connection between the moral circle and generosity was found to be weaker. Three robustness checks further affirmed that these findings are robust. The research confirmed a positive relationship between the moral circle and generosity in a multinational context but also highlighted the moderating role of cultural religiosity. This finding suggested that future research should further investigate how cultural and religious frameworks influence ethical behaviour.

14.
Int J Psychol ; 59(2): 322-330, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-37949828

RESUMEN

Initial validation of the Generic Conspiracist Beliefs Scale (GCBS) identified five correlated factors: Government Malfeasance, Malevolent Global Conspiracies, Extraterrestrial Cover-up, Personal Well-being and Control of Information. Despite replications of this structure, ensuing research, mostly using translated versions of the GCBS (i.e., Persian and Japanese), has reported factorial alternatives. Concomitantly, researchers postulated that belief in conspiracies was higher in historically troubled societies (e.g., Serbia). To further assess the cultural stability of the five correlated factor solution and test the assumption that GCBS scores are affected by social-political instability, a Serbian adaptation of the GCBS was assessed alongside the standard English language version. Data were collected from Serbian (n = 259, 44.40% males) and UK samples (n = 402, 52.25% males). Within samples, confirmatory factor analysis replicated the five-factor solution. Additionally, national and gender invariance was confirmed. National comparisons (Serbia vs. UK) revealed that the Serbian sample scored higher on Government Malfeasance, Malevolent Global Conspiracies, Personal Well-being and Control of Information, whereas the UK sample scored higher on Extraterrestrial Cover-up. There were no gender differences on GCBS factors. Findings indicated that while the Serbian GCBS was interpreted similarly to the GCBS, societal factors influenced endorsement of belief facets.


Asunto(s)
Lenguaje , Masculino , Humanos , Femenino , Serbia , Análisis Factorial
15.
Br J Sociol ; 2024 Oct 09.
Artículo en Inglés | MEDLINE | ID: mdl-39382002

RESUMEN

This study employs latent class analysis (LCA) as a novel methodology to investigate the multidimensional nature of meritocratic beliefs, addressing the limitations of traditional unidimensional approaches. Using data from the International Social Survey Program 2009 for the United States, Finland, and China, this study demonstrates several advantages of this multidimensional approach. First, LCA effectively identifies dual consciousness, where individuals simultaneously endorse meritocratic and structuralist explanations of social stratification. The analysis reveals three distinct narratives explaining social stratification: purely meritocratic beliefs, predominantly meritocratic beliefs, and dual consciousness. While all three subtypes consider merits highly important, they differ in their perceived importance of structural factors. Second, LCA facilitates cross-national comparisons, unveiling qualitative typological variations in meritocratic beliefs across countries. Unique country-specific subtypes or patterns emerge: Finland exhibits purely meritocratic beliefs, the United States shows predominantly meritocratic beliefs, and China demonstrates a dominance of dual consciousness. Although dual consciousness exists in all three countries, its prevalence varies significantly-dominant in China, moderate in the United States, and least in Finland. Third, this study reveals that the effect of education on meritocratic beliefs varies across the three countries. Education strengthens individual meritocratic beliefs in the United States, weakens them in Finland, and shows no significant effect in China. These findings highlight both within-country and across-country heterogeneity of meritocratic beliefs, underscoring the importance of a multidimensional approach.

16.
Psychogeriatrics ; 24(3): 565-571, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38382557

RESUMEN

BACKGROUND: While rapid population ageing is occurring worldwide, its speed is especially prominent in Asian countries. In Asia, cultural diversity might significantly affect care burden; however, few studies have investigated the differences in care burden, and mental, physical and social conditions among Asian countries. This study aimed to clarify the situations of and differences in family caregivers (FCs) of older persons in Japan and Thailand, and evaluate the factors associated with care burden in both countries. METHODS: A cross-national survey of 217 in-home FCs was conducted in Japan and Thailand and mainly included items regarding care burden and psychosocial conditions. Differences between the two countries were obtained, and the factors associated with care burden were analysed by multiple regression analyses. RESULTS: The FCs' and care receivers' mean ages (64.8 ± 11.1 and 84.8 ± 8.6 years, respectively) in Japan were significantly higher than the mean ages (49.1 ± 13.3 and 77.1 ± 9.5 years) in Thailand. In Japan, FCs had more severe care burden, loneliness, and stress compared to those in Thailand. In Thailand, FCs had more social connections and informal support than those in Japan. The factors associated with care burden were different in each country; thus, severe stress, low emotional care preparation, and low willingness to continue care at home were significantly associated with severe care burden in Japan, whereas poor relationships with care receivers, few social connections, low confidence in providing care, low emotional care preparation, and lack of informal support were significantly associated with severe care burden in Thailand. CONCLUSIONS: Despite there being a long-term care insurance system in Japan, which is absent in Thailand, care burden and psychosocial conditions of FCs might be worse in Japan. There was a clear difference in the factors associated with care burden between Japan and Thailand.


Asunto(s)
Cuidadores , Humanos , Tailandia , Masculino , Cuidadores/psicología , Cuidadores/estadística & datos numéricos , Japón , Femenino , Anciano , Persona de Mediana Edad , Anciano de 80 o más Años , Encuestas y Cuestionarios , Comparación Transcultural , Apoyo Social , Estrés Psicológico/epidemiología , Estrés Psicológico/psicología , Estudios Transversales , Carga del Cuidador/psicología , Soledad/psicología , Adulto , Familia/psicología
17.
J Aging Soc Policy ; : 1-19, 2024 May 05.
Artículo en Inglés | MEDLINE | ID: mdl-38704670

RESUMEN

Previous research has shown that providing intensive informal care can have a negative effect on an individual's mental health. However, few studies have been able to draw a precise comparison between the experiences of in-home and out-of-home caregivers. This study used data from 16 countries collected from 2011-2019 as part of the Survey of Health, Ageing and Retirement in Europe (SHARE) to conduct asymmetric panel fixed-effects models that examined within-person variation in depression scores after a respondent started providing daily or almost daily personal care either inside or outside of their home. The results substantiated previous findings that in-home caregivers experience more pronounced increases to their reported depressive symptoms after starting to provide daily personal care than do out-of-home caregivers. In addition, in-home caregivers in countries with greater governmental responsibility for long-term care provision (The Northern and Central Clusters) reported fewer increases to their depressive symptoms after starting to provide care than caregivers in countries where long-term care responsibility predominantly rests on families (The Southern and Eastern Cluster). Further, Northern Cluster countries most successfully shrank the pool of out-of-home care providers. Together, these findings underscore the context-specific nature of caregiver wellbeing.

18.
Occup Ther Health Care ; 38(2): 472-484, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38304992

RESUMEN

Students approach learning in different ways, and this study aimed to examine and understand differences in learning approaches between occupational therapy students in Norway and the USA. A total of 321 students, from two universities in the USA and six higher education institutions in Norway, completed the short version of the Approaches and Study Skills Inventory for Students. The data were analyzed with linear regression analyses. U.S. students had substantially higher scores on the strategic approach and higher scores on the deep approach, compared to the Norwegian students. Differences may be due to different national regulations and levels of education required for entering the programs, or personal factors such as predisposition for learning.


Asunto(s)
Terapia Ocupacional , Humanos , Terapia Ocupacional/educación , Estudiantes , Aprendizaje , Noruega , Instituciones Académicas
19.
Int J Cancer ; 152(11): 2351-2361, 2023 06 01.
Artículo en Inglés | MEDLINE | ID: mdl-36632000

RESUMEN

Immune checkpoint inhibitors (ICIs) are currently one of the most popular treatment methods for cancers. Several ICIs have been approved in China and the United States. We created a database of approved ICIs by extracting the information of interest from the drug labels and reviewing documents disclosed on the official websites of the US Food and Drug Administration (FDA) and the Center for Drug Evaluation (CDE) of the China National Medical Products Administration (NMPA) and compared the difference between the marketed ICIs in China and the United States regarding the number of indications, tumor types, review time, treatment setting, and so forth. Until June 30, 2022, 9 and 15 ICIs had been approved for 86 and 58 indications in the United States and China, involving 20 and 14 types of tumors, respectively. The correlation between indications and disease incidence was higher in China (r = 0.64) than in the United States (r = 0.45). About half of the indications were approved as first-line therapies in combination with chemotherapy, target therapy, or immunotherapy. Over 30% of indications were approved under accelerated or conditional approval in the two countries. A shorter regulatory review time was required by the FDA (median:181 days) compared to the NMPA (median: 279 days) for the new indication approval. Five ICIs marketed in China were approved by the FDA before the NMPA, with the median launch delay for the same indication of 344 days in China. A differentiated clinical development program that focuses on meeting unmet needs may bring new success for subsequent ICI products.


Asunto(s)
Inhibidores de Puntos de Control Inmunológico , Neoplasias , Humanos , Estados Unidos , Inhibidores de Puntos de Control Inmunológico/uso terapéutico , Neoplasias/tratamiento farmacológico , Neoplasias/patología , China , Inmunoterapia/métodos
20.
Pharmacoepidemiol Drug Saf ; 32(9): 1021-1031, 2023 09.
Artículo en Inglés | MEDLINE | ID: mdl-36942801

RESUMEN

PURPOSE: A cross-national comparative (CNC) study about opioid utilization would allow the identification of strategies to improve pain management and mitigate risk. However, little is known about the accessibility and validity of information in healthcare databases internationally. This study aimed to identify the feasibility of using healthcare databases to conduct a CNC study of opioid utilization and its associated consequences. METHODS: A cross-sectional survey was launched in March 2018, including experts interested in CNC studies comparing opioid utilization by purposeful sampling. An electronic survey was used to collect database characteristics, medicine information, and linkage information of each aggregate-level dataset (AD) and individual patient-level dataset (IPD). RESULTS: Overall, participants from 21 geographical regions reported 18 ADs and 19 IPDs. Information on dispensed medications is available from 17 ADs and 17 IPDs. Of the 16 ADs that include primary care settings, only 9 ADs can obtain information from secondary care settings. Fourteen IPDs included patients' characteristics or could be retrieved from linkage databases. Although most ADs are publicly accessible (n = 13), only five IPDs can be accessed without extra cost. CONCLUSION: Most ADs could be used to report opioid utilization in a primary care setting. IPDs with linkage databases should be applied to identify potential determinants, clinical outcomes, and policy impact. Data access restrictions and governance policies across jurisdictions can be challenging for timely analysis and require further collaboration.


Asunto(s)
Analgésicos Opioides , Trastornos Relacionados con Opioides , Humanos , Analgésicos Opioides/efectos adversos , Estudios Transversales , Estudios de Factibilidad , Trastornos Relacionados con Opioides/epidemiología , Trastornos Relacionados con Opioides/prevención & control , Trastornos Relacionados con Opioides/tratamiento farmacológico , Pautas de la Práctica en Medicina
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