[The syndrome of psycho-sensory-anatomical-functional auto-desadaptation in patients with malignant tumors of the maxillofacial region]. / Sindrom psikho-sensorno-anatomo-funktsional'noi autodezadaptatsii u bol'nykh so zlokachestvennymi opukholyami chelyustno-litsevoi oblasti.

OBJECTIVE: The aim of the study is to evaluate the syndrome of PSAF-autoadaptation in patients with tumors of maxillofacial localization based on the analysis of the results of a survey of the patient's Voluntary Confidential Information Sheet (DDIV Sheet). MATERIAL AND METHODS: The object of the study was 110 patients (39 men and 71 women (average age 58 years) with malignant neoplasms of the skin, tongue, bottom of the oral cavity, parotid salivary gland, upper jaw, submandibular salivary gland (stage II-IV of the disease). Rapid diagnostics of psycho-sensory-anatomical-functional-autoadaptation (PSAF) was performed by analyzing self-filled patient lists of DDIV with its self-assessment of the main complaints. After distributing complaints and manifestations of the disease into 4 clusters, the severity and structure of autoadaptation were calculated in points. RESULTS: It was found that in the majority of cancer patients in the preoperative period, complaints related to mental and functional clusters prevailed. At the same time, 80% of patients rated the degree of concern for their health as extremely alarming, and 20% as very anxious. In the postoperative period, the number of psychological complaints decreased and the number of complaints corresponding to anatomical, sensory and functional clusters increased. CONCLUSION: The study of personal response to the disease according to PSAF-autoadaptation of cancer patients showed that the presence of a tumor lesion not only affects the internal picture of the disease, adversely affects the physical, mental and social well-being of patients, but also requires the involvement of psychologists, psychotherapists, clinical pharmacologists in the treatment of cognitive behavioral psychotherapy.

A retrospective analysis for the management of oromaxillofacial invasive mucormycosis and systematic literature review.

PURPOSE: Mucormycosis is a type of fatal infectious disease, rarely involved in the oromaxillofacial region. This study aimed to describe a series of 7 cases with oromaxillofacial mucormycosis and to discuss the epidemiology, clinical features, and treatment algorithm thereof. METHODOLOGY: Seven patients in the author's affiliation have been treated. They were assessed and presented as per their diagnostic criteria, surgical approach, and mortality rates. Reported cases of mucormycosis originally happened in craniomaxillofacial region were synthesized through a systematic review so as to better discuss its pathogenesis, epidemiology, and management. RESULTS: Six patients had a primary metabolic disorder, and one immunocompromised patient had a history of aplastic anemia. The criteria for a positive diagnosis of invasive mucormycosis were based on clinical presentation of signs and symptoms, and a biopsy for microbiological culture and histopathologic analysis. Each patient used antifungal drugs and five of them also underwent surgical resection at the same time. Four patients died due to the unregulated spread of mucormycosis, and one patient died owing to her main disease. CONCLUSIONS: Although uncommon in clinical practice setting, mucormycosis should be of great concern in oral and maxillofacial surgery, due to the life-threatening possibility of this disease. The knowledge of early diagnosis and prompt treatment is of utmost importance for saving lives.

INFLUENCE OF BAD HABITS ON THE DEVELOPMENT OF ACQUIRED DEFORMATIONS IN THE MAXILLOFACIAL AREA.

OBJECTIVE: The aim: Identifying the relationship between the presence of oral habit and acquired maxillomandibular anomalies, influence of oral habits on the skeleton and muscular system formation in children. PATIENTS AND METHODS: Materials and methods: We conducted clinical, radiological methods of examination of 60 patients aged 9-12 with acquired maxillomandibular anomalies, 15 persons aged 9-12 years without maxillomandibular anomalies and acquired deformities (norm group) and 15 persons aged 9-12 years with hereditary syndromes, which are combined with bone deformities in the maxillofacial area (comparison group). RESULTS: Results: Clinical examination showed that oral habits were manifested in 98.3% of patients. The results of clinical and radiological examination, analysis of cephalometric parameters and data on the thickness of the masticatory muscles on symmetrical areas of the face confirm the relationship between chronic oral habits and formation of acquired maxillomandibular anomalies; confirm the presence of acquired rather than congenital deformity of the facial skeleton, which is associated with changes in the thickness of the masticatory muscles on the part of the deformation та compensatory muscle hypertrophy on the opposite side. CONCLUSION: Conclusions: The oral habit should be considered as one of the triggers in the development of acquired deformities of the maxillofacial area.

IMMUNITY CHANGES IN PATIENTS WITH ACUTE MAXILLOFACIAL ODONTOGENIC INFECTIONS DURING TREATMENT STAGES: AN ANALYSIS.

OBJECTIVE: The aim: Evaluate the expediency of using different methods of treatment for patients with acute purulent-odontogenic inflammatory processes in both the main and control groups. This assessment will be based on various indicators of non-specific immunity. PATIENTS AND METHODS: Materials and methods: This study involved the evaluation of the humoral component of nonspecific immunity in 114 patients. We assessed changes in total protein and its fractions, C-reactive protein (CRP), lysozyme, and immunoglobulins (A, M, and G) during three distinct time intervals: 1-3 days, 5-7 days, and 8-14 days after treatment initiation. Statistical analysis was conducted using Statistica 10.0 (StatSoft, Inc., USA) and Microsoft Office Excel 2010. RESULTS: Results: At different postoperative follow-up periods, a significant improvement in humoral nonspecific immunity indicators (p>0.05) was observed when comparing patients treated with and without platelet-rich plasma. This improvement is expected to enhance reparative processes and expedite recovery. CONCLUSION: Conclusions: The incorporation of platelet-rich plasma, immunocorrective, and adaptogenic therapy into the comprehensive treatment of acute purulent odontogenic inflammatory processes in the maxillofacial region not only leads to pronounced and enduring positive outcomes but also results in substantial improvements, including the potential normalization of key humoral and cellular factors associated with innate immunity.

[Radiology department of the Central Research Institute of Dentistry and Maxillofacial Surgery: stages of research work]. / Rentgenologicheskoe otdelenie FGBU NMITs «TsNIIS i ChLKh¼ Minzdrava Rossii: etapy nauchno-issledovatel'skoi raboty.

The stages of the 60-year period of scientific research in the X-ray department of Central Research Institute of Dentistry and Maxillofacial Surgery. The research work was carried out in parallel with the improvement of X-ray diagnostics in dentistry and maxillofacial surgery based on the use of modern specialized X-ray equipment: panoramic radiography of the jaws, linear and panoramic zonography of the maxillofacial region, CT and CBCT of facial bones. For many decades, the department has been developing methodological and organizational foundations for X-ray examination of patients, conducted a comparative assessment of the informative value of X-ray techniques, studied the radiographic features of inflammatory, traumatic, tumor, tumor-like, congenital, post-traumatic and systemic pathological processes in the dental system and maxillofacial region.

Negative pressure drainage-assisted irrigation for maxillofacial space infection.

OBJECTIVE: In this study, the clinical effect of negative pressure drainage-assisted irrigation (NPDI) technique was evaluated in treating maxillofacial space infection (MSI) by comparing with traditional technique. METHOD: A prospective study was conducted in 58 patients with MSI. The patients were randomly divided into two groups based on different treatment techniques. Thirty patients receiving NPDI were included in NPDI group, and 28 patients receiving traditional technique were included in traditional group. Case data (gender, age, etiology, concurrent illness, diabetes, involved spaces, preoperative white cell count, airway control method) and clinical effect (postoperative hospital stay, total cost of admission) for the two groups were analyzed. RESULTS: Patients in both groups were cured clinically. There were no significant differences in gender, age, etiology, concurrent illness, diabetes, involved spaces, preoperative white cell count, and airway control method in NPDI group and traditional group (p > .05). The postoperative hospital stay and the total cost of admission in the NPDI group were significantly lower than the traditional group (p < .001). CONCLUSION: Negative pressure drainage-assisted irrigation used in the treatment of MSI can shorten the postoperative hospital stay, reduce the total cost of admission, and show favorably clinical effect. It is a clinically recommended method for MSI.

Bitten wounds of the maxillofacial area in children.

OBJECTIVE: The aim of the work is to determine the frequency, structure, features of clinical manifestations and treatment of bitten wounds of the face and neck in children of Poltava region. PATIENTS AND METHODS: Materials and methods: It has been analyzed 91 histories of disease of thematic patients undergone treatment at the Surgical Department of Pediatric town clinical hospital of Poltava. RESULTS: Results: In the structure of traumatic injuries of maxillofacial area in children 5.3% were patients with bitten wounds of the face and neck. Among the injured were children of the age 7-12 years old (30.2%). In 74.7% of cases, the bites were complicated by acute inflammatory processes. Urban residents accounted for 71.8% of the total number of cases, while rural residents accounted for 28.2%. Boys were injured by 53.6% and girls by 46.4%. Sharps (74.5%), punctures (19.3%) and lacerations (6.2%) differed in form. The comprehensive treatment of patients with bitten maxillofacial area wounds was carried out according to the protocol of care. CONCLUSION: Conclusions: The clinical picture and severity of bitten wounds of maxillofacial area in children have individual features, which are largely due to topographic and anatomical localization of injuries. The choice of the optimal variant of primary surgical treatment of wounds and the amount of surgery should be determined individually depending on the severity of the injury, the time of injury. Special attention should be paid to normalization of psycho-emotional state of patients and prevention of scar formation.

Insect bites as the cause of infectious and allergic inflammatory processes of the maxillofacial area in children.

OBJECTIVE: Introduction: The part of purulent inflammatory processes (IP) of the maxillofacial area (MFA) as a result of insect bites are increased. The aim: To attract attention of the medical community to the problem of the complexity of the diagnosis and treatment of these dermatogenic forms of IP MFA. PATIENTS AND METHODS: Materials and methods: The work is based on the results of 5 year observations of 42 patients with acute IP MFA arising after insect bites, their comprehensive examination and treatment. CONCLUSION: Conclusions:1. IP of MFA, arising as a result of insect bites, is a very urgent problem of pediatric surgical dentistry and require an individual approach in the diagnosis and treatment of patients. 2. A large role in preventing the occurrence of these nosological forms is given to medical workers, a sufficient organization level of sanitary and educational work, and the treatment of such cases becomes a common task of doctors of different profiles. However, much depends on the parents, their level of responsibility and competency, ensuring of timely treatment and provision of qualified medical care to children, preventing the development of severe complications. 3. The issues related to the etiopathogenesis of this pathology require profound scientific research.

[The experimental clinical substantiation of treatment of patients with odontogenic phlegmon of maxillofacial area using Dаlargin in complex therapy.]

The patients with odontogenic phlegmon of maxillofacial area suffer from immune depression at the surgical stage of treatment that can unfavorably affect their rehabilitation. The study analyzes possibility of application of medication Dalargin in complex treatment of patients during post-operation period. The experimental study established components of immune system affected by medication. Thereupon, Dalargin was applied in clinical practice of treatment of patients with course of disease of average severity. The study proved immunomodulatory characteristics of Dalargin effecting various fractions of sub-populations of lymphocytes and manifesting by way of decreasing of initially high indices and increasing of initially low indices that is of great importance during treatment of patients with odontogenic hormones, especially in case of severe course of disease.

Matrixins in the Salivary Fluid of Patients with Tumors of the Maxillofacial Region during Orthopedic Rehabilitation with Different Prosthetic Structures.

Dental and immunological features of the influence of various prosthetic structures of orthopedic prostheses on tissues and organs of the maxillofacial region were evaluated by the parameters of expression of oral fluid biomarkers. Healthy people without tumor and somatic diseases and patients with neoplasms of maxillofacial area in need of dental rehabilitation were examined before and in 2 weeks and 3 months after treatment. Certain regularities in the reaction of biomarkers to orthopedic prostheses were observed: a decrease in activity of MMP-2 and MMP-8 and their inhibitors or an increase in MMP-9; an increase in activity of biomarkers at early terms and a decrease in delayed terms after prosthetics.

Differences in clinical manifestations of odontogenic and non-odontogenic lymphadenitis.

INTRODUCTION: The acute suppurative lymphadenitis and its chronic forms prevail in the structure of inflammatory processes of the maxillofacial area in children. High incidence of the acute and chronic forms of lymphadenitis of both odontogenic and nonodontogenic origin is caused by the anotomophysiological peculiarities of the structure of the teeth and soft tissues in children in different age periods. THE AIM: The paper was aimed at comparison of clinical manifestations of the acute and chronic odontogenic and non-odontogenic lymphadenitis. MATERIALS AND METHODS: The results of the checkup and 5-year-period treatment of 324 children with the acute and chronic forms of the nonspecific lymphadenitis of the maxilifacial area have been used. Four study groups have been formed. The first and the second group included 16 (38,0%) and 26 (62%) children with the acute submandibular suppurative lymphadenitis of the odontogenic and nonodontogenic origin, respectively. 12 (35,3%) and 22 (64,7) individuals with chronic hyperplastic lymphadenitis have been assigned to the third and the fourth group, respectively. RESULTS: The clinical course of the acute submandibular suppurative lymphadenitis of various etiologies is different. Rapid development of the local clinical manifestations with its dramatic progressing is specific to odontogenic lymphadenitis. Its clinical course is characterized by the more apparent overall response of the body, increase of the body temperature, and these symptoms are more manifested than in nonodontogenic lymphadenitis. The clinical course of chronic hyperplastic lymphadenitis is accompanied by the enlarged regional lymph nodes of various size and shapes and dense-elastic consistency. Clinical manifestations of nonodontogenic lymphadenitis were less apparent and the overall sate was normal in both forms of lymphadenitis. CONCLUSIONS: Nonodontogenic lymphadenitis prevailed in all nosological forms of the acute and chronic nonspecific lymphadenitis.

Microbiological substantiation of the effectiveness of quercitin and its combination with ethylmethylhydroxypyridine succinate in the complex treatment of odontogenic phlegmon and maxillofacial abscesses.

Odontogenic infections can become life-threatening. The aim of the study was to determine the effectiveness of quercitin and its combination with ethylmethylhydroxypyridine succinate in the complex treatment of odontogenic infections by assessing the microbial population of the infection site. Materials and methods: The cross-sectional study included 75 patients. Purulent exudate was collected from the infection site. The number of colony-forming units was counted using the standard plate method. Results: The microbiological examination of purulent exudate obtained from the patients revealed the general prevalence of Gram-positive cocci. On the seventh day of treatment, the total number of microorganisms in the purulent exudate of patients in group I, whose treatment included a combination of the standard protocol with quercitin, significantly decreased compared to the first day of the same group. The results of treatment of patients in group II, which included the standard protocol in combination with quercitin and 2-ethyl-6-methyl-3-hydroxypyridine succinate, demonstrate a significant decrease in the total number of bacteria in the infection focus on the fifth day of treatment compared to this indicator of the group at the beginning of the study. Conclusions: When quercitin was used as part of complex treatment, the total treatment period was reduced by 1.4 days. However, the combined use of quercitin and ethylmethylhydroxypyridine succinate against the background of standard treatment of patients with odontogenic infection contributed to a reduction in hospital stay by 2 days.

Experimental Early Stimulation of Bone Tissue Neo-Formation for Critical Size Elimination Defects in the Maxillofacial Region.

A biomaterial is proposed for closing extensive bone defects in the maxillofacial region. The composition of the biomaterial includes high-molecular chitosan, chondroitin sulfate, hyaluronate, heparin, alginate, and inorganic nanostructured hydroxyapatite. The purpose of this study is to demonstrate morphological and histological early signs of reconstruction of a bone cavity of critical size. The studies were carried out on 84 white female rats weighing 200-250 g. The study group consisted of 84 animals in total, 40 in the experimental group and 44 in the control group. In all animals, three-walled bone defects measuring 0.5 × 0.4 × 0.5 cm3 were applied subperiosteally in the region of the angle of the lower jaw and filled in the experimental group using lyophilized gel mass of chitosan-alginate-hydroxyapatite (CH-SA-HA). In control animals, the bone cavities were filled with their own blood clots after bone trepanation and bleeding. The periods for monitoring bone regeneration were 3, 5, and 7 days and 2, 3, 4, 6, 8, and 10 weeks. The control of bone regeneration was carried out using multiple morphological and histological analyses. Results showed that the following process is an obligatory process and is accompanied by the binding and release of angiogenic implantation: the chitosan construct actively replaced early-stage defects with the formation of full-fledged new bone tissue compared to the control group. By the 7th day, morphological analysis showed that the formation of spongy bone tissue could be seen. After 2 weeks, there was a pronounced increase in bone volume (p < 0.01), and at 6 weeks after surgical intervention, the closure of the defect was 70-80%; after 8 weeks, it was 100% without violation of bone morphology with a high degree of mineralization. Thus, the use of modified chitosan after filling eliminates bone defects of critical size in the maxillofacial region, revealing early signs of bone regeneration, and serves as a promising material in reconstructive dentistry.

Evaluation of Direct and Cell-Mediated Lactoferrin Gene Therapy for the Maxillofacial Area Abscesses in Rats.

Resistance to antibacterial therapy requires the discovery of new methods for the treatment of infectious diseases. Lactoferrin (LTF) is a well-known naïve first-line defense protein. In the present study, we suggested the use of an adenoviral vector (Ad5) carrying the human gene encoding LTF for direct and cell-mediated gene therapy of maxillofacial area phlegmon in rats. Abscesses were developed by injection of the purulent peritoneal exudate in the molar region of the medial surface of the mandible. At 3-4 days after phlegmon maturation, all rats received ceftriaxone and afterward were subcutaneously injected around the phlegmon with: (1) Ad5 carrying reporter gfp gene encoding green fluorescent protein (Ad5-GFP control group), (2) Ad5 carrying LTF gene (Ad5-LTF group), (3) human umbilical cord blood mononuclear cells (UCBC) transduced with Ad5-GFP (UCBC + Ad5-GFP group), and (4) UCBC transduced with Ad5-LTF (UCBC + Ad5-LTF group). Control rats developed symptoms considered to be related to systemic inflammation and were euthanized at 4-5 days from the beginning of the treatment. Rats from therapeutic groups demonstrated wound healing and recovery from the fifth to seventh day based on the type of therapy. Histological investigation of cervical lymph nodes revealed purulent lymphadenitis in control rats and activated lymphatic tissue in rats from the UCBC + Ad5-LTF group. Our results propose that both approaches of LTF gene delivery are efficient for maxillofacial area phlegmon recovery in rats. However, earlier wound healing and better outcomes in cervical lymph node remodeling in the UCBC + Ad5-LTF group, as well as the lack of direct exposure of the viral vector to the organism, which may cause toxic and immunogenic effects, suggest the benefit of cell-mediated gene therapy.

The structure of odontogenic inflammation among children / Монголын Анагаах Ухаан

Introduction@#The department of Maxillofacial surgery of the National Center for Maternal and Child Health (NCMCH) has a nationwide tertiary medical service for the children who is with congenital orofacial anomalies, facial injury, nonmalignant tumors of this area, and inflammations of maxillofacial area following odontogenic infection and other reasons as well. For the last years the number of the patients who are with odontogenic inflammation on the department has been growing constantly meaning that the necessity of medical care for our countries for children is also growing. Therefore by studying and analyzing the structure of the odontogenic inflammation and to determine the most frequent odontogenic inflammation among children in our country, to prevent them, define the treatment plan.@*Aim@#To clarify what kind of odontogenic maxillofacial inflammatory diseases mainly occurs among Mongolian children. @*Materials and Method@#We included all patients who are with odontogenic inflammation and underwent emergency and planned surgery in the department of Maxillofacial surgery, NCMCH between 2014-2018. </br> We used descriptive method based on the information of inpatients history record between 2014.01.01- 2018.12.31 at the department of Maxillofacial surgery, NCMCH and using our own –designed, prescreened survey card.</br> Statistical data processing is done using Microsoft Office-2019, SPSS for windows and STATA programs, and the results are shown illustrated method. The survey identified the incidence and frequency of each disease classification, and analyzed the characteristics of the child’s age, sex, and residency.@*Result @#In total 3533 children with odontogenic inflammation, whom age range is 0-18 years old, admitted at the department of Maxillofacial surgery for the surgical treatment were involved in this study.</br> Among which 1452(41.1%) male, 2081(58.9%) female. Considering the residency 2918(82.5%) children from Ulan-Bator and 615 (17.5%) children from countryside. The most of patients, who involved in this study were with odontogenic periostitis of maxillofacial area (67.5%), most were girls and preschool age (3-5 ages).@*Conclusion@#Based on the result of our study the most frequent inflammation was odontogenic periostitis of maxilla and mandible bone with 67.5%. The odontogenic phlegmon of orofacial area was the 2nd most frequent with 25.1%.</br> Inflammation of maxillofacial area was most frequent in 3-5 age group (preschool age) with 41.4%, and mostly in male. Considering the residency with 82.5% highest in Ulanbator.

Bone and soft tissue non-Hodgkin lymphoma of the maxillofacial area: report of two cases, literature review and new therapeutic strategies.

Primary mandibular non-Hodgkin lymphoma (NHL) and soft tissues NHL of the maxillofacial are extremely rare representing a minimal percentage of the head and neck tumors. Two cases of bone and soft tissue maxillofacial NHL are reported. Clinical, radiological and pathological features are described and the therapeutic procedures are discussed accordingly. Mandibular radiologic features have been carefully analyzed and discussed to achieve an early and accurate diagnosis avoiding improper dental therapies.

The structure of disease among children department of maxillofacial surgery / Монголын Анагаах Ухаан

Introduction@#The department of Maxillofacial surgery of the National Center for Maternal and Child Health (NCMCH) has a nationwide tertiary medical service on the patients who is with congenital orofacial anomalies, facial injury, nonmalignant tumors of this area, and inflammations of maxillofacial area following dental caries and other reasons as well. For the last years nationwide the number of inpatient of the department has been growing constantly meaning that the necessity of medical care for our countries for children is also growing. Therefore by studying and analyzing the structure of the illness of the department will be able to determine the most frequent orofacial illness among children in our country, to prevent them, define the treatment plan.@*Aim@#To clarify what disease in the Maxillofacial area mainly occurs among Mongolian children. @*Materials and Method@#We included all patients who underwent emergency and planned surgery in the department of Max-illofacial surgery, NCMCH between 2014-2015. </br> We used descriptive and case-control method based on the information of inpatients history record between 2014.01.01-2015.01.01 at the department of Maxillofacial surgery, NCMCH and using our own –designed, pre-screened survey card. </br> Statistical data processing is done using Microsoft Office-2017 and SPSS for windows programs, and the results are shown illustrated method. The survey identified the incidence and frequency of each disease classification, and analyzed the characteristics of the child’s age, sex, and residency.@*Result@#The most of patients, who involved in this study were with the inflammation of maxillofacial area (57%), and the congenital orofacial clefts (24.4%). </br> In total 3300 children from 0-18 years old admitted at the department of Maxillofacial surgery and Infants study for orofacial surgery treatment were involved in this study. </br> Among which were 1803(54.6%) male, 1497(45.4%) female. Considering the residency, 2525(76.5%) children from Ulaanbaatar and 775 (23.5%) children from countryside. The most of patients, who involved in this study, were with the inflammation of maxillofacial area (57%), and the congenital orofacial clefts (24.4%).@*Conclusion@#Based on the result of our study the highest incidence among the participants was inflammation of maxillofacial area with 57% in which odontogenic periostitis was the most frequent with 21.6%. Congenital orofacial clefts and disorders was the 2^nd most frequent with 24.4%. Inflammation of maxillo-facial area was most frequent in 0-2 age group with 33.7%, and mostly in male. Considering there were residency with 83.2% highest in Ulaanbaatar and mostly in Bayanzurkh district with 24.7%.

Polyostotic Fibrous Dysplasia of Cranio-Maxillofacial Area / 대한구강악안면방사선학회지

Fibrous dysplasia is believed to be a hamartomatous developmental lesion of unknown origin. This disease is divided into monostotic and polyostotic fibrous dysplasia. Polyostotic type can be divided into craniofacial type, Lichtenstein-Jaffe type, and McCune-Albright syndrome. In this case, a 31-year-old female presented spontaneous loss of right mandibular teeth before 5 years and has shown continuous expansion of right mandibular alveolus. Through the radiographic view, the coarse pattern of the mixed radiopaque-lucent lesion was seen on the right mandibular body, and there was diffuse pattern of the mixed radiopaque-lucent lesion with ill-defined margin in the left mandibular body. In the right calvarium, the lesion had cotton-wool appearance. Partial excision for contouring, multiple extraction, and alveoloplasty were accomplished under general anesthesia for supportive treatment. Finally we could conclude this case was polyostotic fibrous dysplasia of cranio-maxillofacial area based on the clinical, radiologic finding, and histopathologic examination.

Distraction osteogenesis in correction of severe retro-maxillary deformity after cleft palate repair / 实用口腔医学杂志

Objective: To investigate the distraction osteogenesis technique in correction of severe retro-maxillary deformity following the repair of cleft palate. Methods:10 patients were included in the study. Orthodontic treatment was used as a regular procedure before operation. Distraction osteogenesis technique was used to correct the deformity and malocclusion. 4 of patients applied with the external distractor and others with internal distractor. Latency period was 7 days. Distraction rhythm is 0.8~1 mm/d,2~4 times/d. Consolidation period was 8~12 weeks. Orthognathic surgery was done after distraction finished when necessary. Results:The treatment process was smooth and no severe complication occurred. The maximum of distraction distance is 22 mm, and the minimum of distraction distance was 15 mm. No malunion or ununion occurred in all 10 patients. All the patients were satisfied with the results. Conclusion:Distraction osteogenesis is more suitable for correction of severe retro-maxillary deformity following the repair of cleft palate. Bone transplantation is unnecessary during the operation process with easier handling and lower risk.