[Network Meta-analysis of Qi-supplementing and Yin-nourishing Chinese patent medicines in treatment of early diabetic nephropathy].

This study aimed to evaluate the efficacy of Qi-supplementing and Yin-nourishing Chinese patent medicine in the treatment of early diabetic nephropathy(DN) by network Meta-analysis to explore the Chinese patent medicine with optimal efficacy and provide references for preventing renal deterioration and delaying the progression of early DN. Eight databases, including CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of Science, were searched for clinical randomized controlled trial(RCT) of Qi-supplementing and Yin-nourishing Chinese patent medicines in the treatment of early DN. After the literature mee-ting the inclusion criteria was screened, the quality of the literature was evaluated using the Cochrane risk-of-bias tool, and network Meta-analysis was performed using the BUGSnet package in R 4.2.1. Seventy-two research articles with a sample size of 6 344 cases were included, involving eight Chinese patent medicines and seven outcome indicators. The results of the network Meta-analysis showed that(1)in terms of improving urinary albumin excretion rate(UAER), Chinese patent medicines combined with conventional treatment were superior to conventional treatment, and Qiyao Xiaoke Capsules + conventional treatment was optimal.(2)In terms of reducing serum crea-tinine(Scr), Bailing Capsules + conventional treatment had superior efficacy.(3)In terms of reducing 24-hour urine total protein(24hUTP), Shenyan Kangfu Tablets + conventional treatment and Jinshuibao Capsules + conventional treatment had equivalent efficacy, and Shenyan Kangfu Tablets + conventional treatment was superior.(4)In terms of improving fasting blood glucose(FBG), Shenyan Kangfu Tablets + conventional treatment had superior efficacy.(5)In terms of improving total cholesterol(TC), Qiyao Xiaoke Capsules +conventional treatment had superior efficacy.(6)In terms of reducing triglyceride(TG), Bailing Capsules + conventional treatment had superior efficacy.(7)In terms of safety, the occurrence of adverse reactions was reported in seven interventions, but due to the large clinical heterogeneity, the quantitative analysis could not be performed. Overall, Qi-supplementing and Yin-nourishing Chinese patent medicines combined with conventional treatment were superior to conventional treatment alone in the treatment of early DN. The results showed that Qi-supplementing and Yin-nourishing Chinese patent medicines combined with conventional treatment had good clinical efficacy, and they could significantly reduce renal function indicators such as UAER, Scr, and 24hUTP, and reduce blood sugar and blood lipid, which can provide evidence-based support for the treatment of early DN. However, due to the differences in the quantity and quality of the included research articles, large-sample, multi-center, high-quality studies are still needed for further verification.

Network Meta-analysis of Qi-supplementing and Yin-nourishing Chinese patent medicines in treatment of early diabetic nephropathy / 中国中药杂志

This study aimed to evaluate the efficacy of Qi-supplementing and Yin-nourishing Chinese patent medicine in the treatment of early diabetic nephropathy(DN) by network Meta-analysis to explore the Chinese patent medicine with optimal efficacy and provide references for preventing renal deterioration and delaying the progression of early DN. Eight databases, including CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of Science, were searched for clinical randomized controlled trial(RCT) of Qi-supplementing and Yin-nourishing Chinese patent medicines in the treatment of early DN. After the literature mee-ting the inclusion criteria was screened, the quality of the literature was evaluated using the Cochrane risk-of-bias tool, and network Meta-analysis was performed using the BUGSnet package in R 4.2.1. Seventy-two research articles with a sample size of 6 344 cases were included, involving eight Chinese patent medicines and seven outcome indicators. The results of the network Meta-analysis showed that(1)in terms of improving urinary albumin excretion rate(UAER), Chinese patent medicines combined with conventional treatment were superior to conventional treatment, and Qiyao Xiaoke Capsules + conventional treatment was optimal.(2)In terms of reducing serum crea-tinine(Scr), Bailing Capsules + conventional treatment had superior efficacy.(3)In terms of reducing 24-hour urine total protein(24hUTP), Shenyan Kangfu Tablets + conventional treatment and Jinshuibao Capsules + conventional treatment had equivalent efficacy, and Shenyan Kangfu Tablets + conventional treatment was superior.(4)In terms of improving fasting blood glucose(FBG), Shenyan Kangfu Tablets + conventional treatment had superior efficacy.(5)In terms of improving total cholesterol(TC), Qiyao Xiaoke Capsules +conventional treatment had superior efficacy.(6)In terms of reducing triglyceride(TG), Bailing Capsules + conventional treatment had superior efficacy.(7)In terms of safety, the occurrence of adverse reactions was reported in seven interventions, but due to the large clinical heterogeneity, the quantitative analysis could not be performed. Overall, Qi-supplementing and Yin-nourishing Chinese patent medicines combined with conventional treatment were superior to conventional treatment alone in the treatment of early DN. The results showed that Qi-supplementing and Yin-nourishing Chinese patent medicines combined with conventional treatment had good clinical efficacy, and they could significantly reduce renal function indicators such as UAER, Scr, and 24hUTP, and reduce blood sugar and blood lipid, which can provide evidence-based support for the treatment of early DN. However, due to the differences in the quantity and quality of the included research articles, large-sample, multi-center, high-quality studies are still needed for further verification.

Effects of Qi-supplementing, Blood-activating And Phlegm-resolving on Lung Function And Blood Coagulationin Among Patients of Chronic Obstructive Pulmonary Disease in Acute Stage / 世界科学技术-中医药现代化

This study was aimed to observe the therapeutic effect of qi-supplementing,blood-activating and phlegmresolving on chronic obstructive pulmonary disease (COPD) patients with blood stasis syndrome in the acute stage,and to evaluate the lung function improvement condition.Observation was also made on plasma fibrinogen and D-dimer,in order to provide references for traditional Chinese medicine (TCM) clinical treatment of COPD.A total of 174 acute COPD patients with blood stasis syndrome were selected from October 2015 to July 2017 in the Linqu County People's Hospital of Shandong Province.Patients were randomly divided into the control group and the study group.Conventional western medicine treatment was given to the control group.On the basis of routine western medicine treatment,the study group was treated with TCM qi-supplementing,blood-activating and phlegm-resolving method.The clinical efficacy,changes of lung function,plasma fibrinogen and D-dimer before and after treatment were observed in both groups.The results showed that the total efficacy of the study group was 95.4％,and the total efficacy of the control group was 79.3％.The difference was statistically significant (P ＜ 0.05).Pearson correlation study showed that plasma fibrinogen (r =-0.79,P ＜ 0.05) and D-dimer (r =-0.84,P ＜ 0.05) were negatively correlated with PaO2.Before treatment,there was no significant difference in lung function,plasma fibrinogen and D-dimer between two groups (P ＞ 0.05).After treatment,indicators of both groups were significantly improved,in which the improvement of the study group was more obvious.The difference between two groups was statistically significant (P ＜ 0.05).It was concluded that the expression levels of plasma fibrinogen and D-dimer were closely related to COPD.Qi-supplementing,blood-activating and phlegmresolving method can improve clinical symptoms,blood stasis status and lung function of COPD patients in the acute stage with remarkable curative effect.

Study on Effect ofQi-supplementing and Depression-relieving ofJie-Du Tong-LuoCapsule on Post-stroke Depression Rat Model / 世界科学技术-中医药现代化

This study was aimed to observe behavioral changes of post-stroke depression (PSD) rats, and to assess effect ofJie-Du Tong-Luo(JDTL) capsule onqi-supplementing and depression-relieving. Microspheres were injected from external carotid artery of rats under anesthesia to prepare the multiple cerebral infarction. Aftermid long term feeding, PSD rat model was established. Then, open-field test (OFT), tail suspension test (TST), forced swimming test (FST) and glucose preference test were employed to study behavioral changes of rats. The results showed that rats suffered multiple cerebral infarction after mid long term feeding formed PSD, which were indicated by reduced food consume, slow body weight increasing, reduction of spontaneous movement and inquiry activity, prolonged accumulative immobility time in TST, FST and lowered glucose preference, compared with rats in the normal group. Compared with the model group, rats in the JDTL capsule group andBu-Chang Xin-Nao-Tonggroup showed larger body weight increase, higher scores in OFT, reduced immobility time in TST, FST, and elevated glucose preference. It was concluded that JDTL capsule had significant efficacy on rats’ body weight, behavior and glucose preference, which might be its pharmacological basis onqi-supplementing and depression-relieving.

Study on Qi-supplementing and Mind-tranquilizing Efficacy ofLing-Qi-JiaOral Solution on Heart-spleen Deficiency Mouse / 世界科学技术-中医药现代化

This study was aimed to observe the body weight and behavioral changes of heart-spleen deficiency mouseandtoassesstheefficacyofLing-Qi-Jia (LQJ)oralsolutiononqi-supplementingandmind-tranquilizing. The heart-spleen deficiency syndrome mouse model was established by using loading swimming anddrugdaily.Thebodyweight,foodconsumption,intestinepropulsion,tailsuspensiontest (TST),forced swimmingtest (FST),sleepingtimeandtheamountofbrainneurotransmitterweredetected.Theresultsshowed that mouse suffered loading swimming and drug formed heart-spleen deficiency syndrome model, which were indicated by lowering body weight and food consumption, shortened time in FST, prolonged accumulative immobility time in TST, intestine propulsion hyperfunction, shortened sleeping time and lowering brain neurotransmitter amount. LQJ oral solution can obviously improve experiment indexes mentioned above. It was concluded that LQJ oral solution, which can improve insomnia due to heart-spleen deficiency, might had close relation to the efficacy of qi-supplementing and mind-tranquilizing. Meanwhile, changes of brain neurotransmitters might also be the material basis on its efficacy.

Clinical research on congestive heart failure treated by Qi-supplementing and blood-activating method(益气活血法) / 中国中西医结合急救杂志

Objective: To observe the clinical therapeutic effects of Qisupplementing and blood(activating) method(益气活血法) for congestive heart failure(CHF). Methods: Sixtythree patients with CHF(observation cardiac function Ⅲ or Ⅳ according to the grande scale of cardiac functionNew York(Heart)(Association)(NYHA)) were randomly divided into the observation group(n=42) and the control group((n=21)).The general therapy of the two groups was the same.In addition,orally to the observation group was(administered) a decoction,which includes Radix Ginseng(人参),Radix Ophiopogonis(麦冬),Radix(Salviae)(Miltiorrhizae)(丹参) and Semen Lepidii seu Rescurainiae(葶苈子),and astragalus injection(黄芪注射液) was injected in the Zushanli(ST 36) point,15 days constituting one therapeutic course.Results: In the observation group,the obviously effective rate being the 71.43% and the effective rate was 21.47%,the total effective rate being the 92.90%;ejection fraction(EF) of left ventricle was 0.32?0.04 and 0.48?0.07(before) and after treatment(P