The impact of social comparison on self-deception: An event-related potentials study.

Self-deception refers to an individual holding inflated beliefs about their abilities, and it plays a crucial role in human behavior and decision-making. The present study employed event-related potentials (ERPs) technique to explore the neural responses to the impacts of social comparison direction and comparison gap on self-deceptive behavior. They were instructed to predict their performance in the forward-looking paradigm. Behavioral responses and neural reactions during the decision-making process were documented. The behavioral results indicated that, in contrast to the downward comparison condition, participants engaged in upward comparison exhibited more occurrences of self-deception. However, within the context of upward comparison, participants demonstrated a higher frequency of self-deception in the large gap condition compared with the small gap condition. The ERP results showed that induced self-deception under conditions with a large comparative gap between participants and their paired counterparts stimulated larger P300 and smaller N400 amplitude than under conditions with a small gap. However, when participants were in the upward comparison situation, the late positive potential (LPP) amplitude induced by self-deception behavior in the condition of a large comparison gap between participants and paired opponents was larger than that in the condition of a small comparison gap. These results indicated that individuals in the large gap group feel strong unfairness and negative emotions. More importantly, the self-deception induced by the large gap group in the upward comparison situation used fewer cognitive resources than the small gap condition, whereas the individuals in the downward comparison situation did not show the difference in cognitive resources.

Optimal self-protection and health risk perceptions: Exploring connections between risk theory and the Health Belief Model.

In this contribution to the longstanding risk theory debate on optimal self-protection, we aim to enrich the microeconomic modeling of self-protection, in the wake of Ehrlich and Becker (1972), by exploring the representation of risk perception at the core of the Health Belief Model (HBM), a conceptual framework extremely influential in Public Health studies (Janz and Becker, 1984). In our two-period model, we highlight the crucial role of risk perception in the individual decision to adopt a preventive behavior toward a generic health risk. We discuss the optimal prevention effort engaged by an agent displaying either imperfect knowledge of the susceptibility (probability of occurrence) or the severity (magnitude of the loss) of a health hazard, or facing uncertainty on these risk components. We assess the impact of risk aversion and prudence on the optimal level of self-protection, a critical issue in the risk and insurance economic literature, yet often overlooked in HBM studies. Our results pave the way for the design of efficient information instruments to improve health prevention when risk perceptions are biased.

Structural Basis of the Mechanisms of Action and Immunity of Lactococcin A, a Class IId Bacteriocin.

Lactococcin A (LcnA), a class IId bacteriocin, induces membrane leakage and cell death by specifically binding to the membrane receptor-mannose phosphotransferase system (man-PTS), as is the case for pediocin-like (class IIa) bacteriocins. The cognate immunity protein of bacteriocins, which protects the producer cell from its own bacteriocin, recognizes and binds to the bacteriocin-man-PTS complex, consequently blocking membrane leakage. We previously deciphered the mode of action and immunity of class IIa bacteriocins. Here, we determined the structure of the ternary complex of LcnA, LciA (i.e., the immunity protein), and its receptor, i.e., the man-PTS of Lactococcus lactis (ll-man-PTS). An external loop on the membrane-located component IIC of ll-man-PTS was found to prevent specific binding of the N-terminal region of LcnA to the site recognized by pediocin-like bacteriocins. Thus, the N-terminal ß-sheet region of LcnA recognized an adjacent site on the extracellular side of ll-man-PTS, with the LcnA C-terminal hydrophobic helix penetrating into the membrane. The cytoplasmic cleft formed within the man-PTS Core and Vmotif domains induced by embedded LcnA from the periplasmic side is adopted by the appropriate angle between helices H3 and H4 of the N terminus of LciA. The flexible C terminus of LciA then blocks membrane leakage. To summarize, our findings reveal the molecular mechanisms of action and immunity of LcnA and LciA, laying a foundation for further design of class IId bacteriocins. IMPORTANCE Class IId (lactococcin-like) bacteriocins and class IIa (pediocin-like) bacteriocins share a few similarities: (i) both induce membrane leakage and cell death by specifically binding the mannose phosphotransferase system (man-PTS) on their target cells, and (ii) cognate immunity proteins recognize and bind to the bacteriocin-man-PTS complex to block membrane leakage. However, class IId bacteriocins lack the "pediocin box" motif, which is typical of class IIa bacteriocins, and basically target only lactococcal cells; in contrast, class IIa bacteriocins target diverse bacterial cells, but not lactococcal cells. We previously solved the structure of class IIa bacteriocin-receptor-immunity ternary complex from Lactobacillus sakei. Here, we determined the structure of the ternary complex of class IId bacteriocin LcnA, its cognate immunity protein LciA, and its receptor, the man-PTS of Lactococcus lactis. By comparing the interactions between man-PTS and class IIa and class IId bacteriocins, this study affords some clues to better understand the specificity of bacteriocins targeting the mannose phosphotransferase system.

For Me or for My Relatives? Approximating Self-Protection and Local Altruistic Motivations Underlying Preferences for Public Health Policies Using Risk Perception Metrics.

OBJECTIVES: Research efforts evaluating the role of altruistic motivations behind health policy support are usually based on direct preference elicitation procedures, which may be biased. We propose an indirect measurement approach to approximate self-protection-related and altruistic motivations underlying preferences for public health policies. METHODS: Our new approach relies on associations between on the one hand decision makers' perceived health risk for themselves and for close relatives and on the other hand their observed preferences for health policies that reduce such risks. The approach allows to make a rough distinction between health-related self-protection and local altruistic motives behind preferences for health policies. We illustrate our approach using data obtained from a discrete choice experiment in the context of policies to relax coronavirus-related lockdown measures in The Netherlands. RESULTS: Our results show that the approach is able to uncover that (1) people who think they have a high chance of experiencing health risks from a COVID-19 infection are more willing to accept a societal or personal sacrifice, (2) people with a higher health risk perception for their relatives have a higher willingness to accept sacrifices than people with a higher health risk perception for themselves, and (3) people who perceive that they have a high risk of dying of COVID-19 have a higher willingness to accept sacrifices than those anticipating less severe consequences of COVID-19. CONCLUSIONS: Our method offers a useful proxy metric to distinguish health-related self-protection and local altruism as drivers of citizens' responses to healthcare policies.

Induction of heme oxygenase-1 antagonizes PM2.5-induced pulmonary VEGFA expression through regulating HIF-1α.

Particulate matter (PM) 2.5 has long been regarded as a major risk factor of the respiratory system, which constitutes a threat to human health. Although the positive relationship between PM2.5 exposure and the development of respiratory diseases has been well established, limited studies investigate the intrinsic self-protection mechanisms against PM2.5-induced respiratory injuries. Excessive pulmonary inflammation served as a key pathogenic mechanism in PM2.5-induced airway dysfunction, and we have previously shown that PM2.5 induced the production of vascular endothelial growth factor A (VEGFA) in the bronchial epithelial cells, which subsequently led to pulmonary inflammatory responses. In the current study, we found that PM2.5 also concurrently induced the expression of the stress-responsive protein heme oxygenase-1 (HO-1) along with VEGFA in the bronchial epithelial cells both in vivo and in vitro. Importantly, knocking down of HO-1 expression significantly increased the synthesis and secretion of VEGFA; while overexpression of HO-1 showed the opposite effects, indicating that HO-1 induction can antagonize VEGFA production in the bronchial epithelial cells upon PM2.5 exposure. Mechanistically, HO-1 inhibited PM2.5-evoked VEGFA induction through modulating hypoxia-inducible factor 1 alpha (HIF-1α), which was the upstream transcriptional factor of VEGFA. More specifically, HO-1 could not only inhibit HIF-1α expression, but also suppress its transactivity. Taken together, our results suggested that HO-1 was an intrinsic protective factor against PM2.5-induced pulmonary VEGFA production with a mechanism relating to HIF-1α, thus providing a potential treatment strategy against PM2.5 triggered airway injuries.

Self-Protection Characteristic Comparison between No-Insulation, Metal-as-Insulation, and Surface-Shunted-Metal-as-Insulation REBCO coils.

The metal tape co-winding or a metal-as-insulation (MI) winding method is an excellent way to improve the mechanical properties and reduce the average current density, thereby decreasing the stress in high-field REBCO magnet without completely losing the benefits of the no-insulation (NI) winding method. However, the MI winding increases the resistance between turns, which is known as characteristic resistance. The increased characteristic resistance can reduce the bypass current during abnormal transition situation, such as quench, which may not be desirable from a magnet protection point of view. To take advantage of both the MI and NI winding, one possible solution to reduce characteristic resistance of the MI winding coils is to add a shunt on top of the winding surface of the coil. We call this method surface-shunted-metal-as-insulation (SSMI). In this presentation, we compare the characteristic resistances and their correlated self-protecting characteristics between NI, MI, and SSMI. We present the test results of single pancake coils which wound using different winding methods (NI, MI, and SSMI) with same winding pressure of 20 N. In particular, we investigated how the SSMI method affects the characteristic resistance.

Effect of cross-border migration on the healthcare system of a destination community: Insights from mathematical modelling of COVID-19 in a developing country.

The movement of persons during the pandemic has played a significant role in increasing the disease transmission rates as well as the spread of COVID-19 variants from one region to another. Although, strict restrictions on movement of persons across borders had been imposed early on in the pandemic, countries had to open up their borders to travel as a way of trying to resuscitate their economies that were declining due to closure of businesses and restriction on both local and international travel. Although the lifting of travel bans was done under strict regulations, there has since been a spike in the number of infection cases and spread of virus variants. These increases have certainly put a lot of strain on the rather limited resources allocated to fighting COVID-19 in most regions including the Eastern and Southern Africa. In this manuscript, we examine the potential role played by cross-border movements on the number of detected cases in a developing country. Here, we consider cases where persons cross borders through either designated controlled border points with proper facilitation for screening and detection of potentially infected cases, as well as border crossings through ungazatted points. The persons crossing borders are considered to be either susceptible, exposed or infected with no or mild symptom. A mathematical model was formulated to cater for the aforementioned classifications as well as additional important dynamics related to the disease. The behaviour of solutions for the model is determined and the conditions for existence of the disease free equilibrium as well as the disease persistent equilibrium ascertained. Finally, a dynamically consistent nonstandard finite difference scheme is proposed to replicate the properties of the continuous model. The baseline model was fitted to data of two waves, parameter values were determined and used to obtain numerical results. Our results show that, an increase in cross border movement can result in an increase in the number of detected cases. We observed that if the number of persons who cross-border points while positive for COVID-19 is reduced by 60%, the total number of detected cases can be reduced by up to 58%. In addition, an 83% increase in immigration of exposed persons can increase the disease burden in a destination country by at least 14%. These results justify border points closures during a pandemic or imposing very stringent measure across borders to curtail the importation of positive cases in a country.

Risk mitigation services in cyber insurance: optimal contract design and price structure.

As the cyber insurance market is expanding and cyber insurance policies continue to mature, the potential of including pre-incident and post-incident services into cyber policies is being recognised by insurers and insurance buyers. This work addresses the question of how such services should be priced from the insurer's viewpoint, i.e. under which conditions it is rational for a profit-maximising, risk-neutral or risk-averse insurer to share the costs of providing risk mitigation services. The interaction between insurance buyer and seller is modelled as a Stackelberg game, where both parties use distortion risk measures to model their individual risk aversion. After linking the notions of pre-incident and post-incident services to the concepts of self-protection and self-insurance, we show that when pricing a single contract, the insurer would always shift the full cost of self-protection services to the insured; however, this does not generally hold for the pricing of self-insurance services or when taking a portfolio viewpoint. We illustrate the latter statement using toy examples of risks with dependence mechanisms representative in the cyber context. Supplementary Information: The online version contains supplementary material available at 10.1057/s41288-023-00289-7.

Structural Basis of the Immunity Mechanisms of Pediocin-like Bacteriocins.

Pediocin-like bacteriocins, also designated class IIa bacteriocins, are ribosomally synthesized antimicrobial peptides targeting species closely related to the producers. They act on the cytoplasmic membrane of Gram-positive cells by dissipating the transmembrane electrical potential through pore formation with the mannose phosphotransferase system (man-PTS) as the target/receptor. Bacteriocin-producing strains also synthesize a cognate immunity protein that protects them against their own bacteriocins. Herein, we report the cryo-electron microscopy structure of the bacteriocin-receptor-immunity ternary complex from Lactobacillus sakei. The complex structure reveals that pediocin-like bacteriocins bind to the same position on the Core domain of man-PTS, while the C-terminal helical tails of bacteriocins delimit the opening range of the Core domain away from the Vmotif domain to facilitate transmembrane pore formation. Upon attack of bacteriocins from the extracellular side, man-PTS exposes its cytosolic side for recognition of the N-terminal four-helix bundle of the immunity protein. The C-terminal loop of the immunity protein then inserts into the pore and blocks leakage induced by bacteriocins. Elucidation of the toxicity and immunity mechanisms of pediocin-like bacteriocins could support the design of novel bacteriocins against antibiotic-resistant pathogenic bacteria. IMPORTANCE Pediocin-like bacteriocins, ribosomally synthesized antimicrobial peptides, are generally co-expressed with cognate immunity proteins to protect the bacteriocin-producing strain from its own bacteriocin. Bacteriocins are considered potential alternatives to conventional antibiotics in the context of the bacterial resistance crisis, but the immunity mechanism is unclear. This study uncovered the mechanisms of action and immunity of class IIa bacteriocins.

Are they out to get me? Individual differences in nonclinical paranoia as a function of narcissism and defensive self-protection.

OBJECTIVE: Three studies tested a novel model of the narcissism-paranoia link, whereby narcissism (primarily its socially maladaptive facets) is associated with paranoia via over-use of defensive self-protection and/or under-use of self-affirmation. METHODS: In Study 1, 245 online volunteers (87% female; MAGE  = 20.92; 44% White-British) completed trait measures of narcissism, self-enhancement/protection strategies and paranoia. In Study 2, 116 students (82% female; MAGE  = 20.23; 70% White-British) completed baseline measures, then reported state reactions and paranoia following two difficult and two pleasant interpersonal events after 3-10 days. In Study 3, 517 online volunteers (64% female; MAGE  = 22.76; 77% White/Caucasian) completed baseline measures, experienced a standardized social exclusion (vs. neutral) manipulation (Cyberball), then reported state reactions and paranoia. RESULTS: In Study 1, narcissism was associated with higher paranoia via defensiveness. In Study 2, this was replicated in difficult but not pleasant events, and was driven by the Entitlement/Exploitativeness facet of narcissism. In Study 3, narcissistic rivalry and vulnerable narcissism, but not admiration, were associated with Cyberball-related paranoia via general defensiveness and denigration of others. CONCLUSIONS: Individuals high in narcissism-especially its socially maladaptive facets-who over-rely on defensive self-protection strategies in response to threat, are particularly vulnerable to paranoia. Findings help to understand individual differences in paranoia.

An Evaluation of the "I am Learning to Protect Myself with Mika" Program Using the "What If" Situations Test.

Despite the recent development of a plethora of child sexual abuse prevention programs in recent years, few studies have attempted to evaluate their effectiveness using a standardized measure. Therefore, we attempted to test the effectiveness of the "I am learning to protect myself with Mika" program using a valid and reliable tool: the "What If" Situations Test (WIST). Eighty-one preschool children and their parents and teachers participated in this study. Ultimately, we compared the data of 43 children (M =  66.78, SD =  8.84) in the intervention group and 38 children (M =  69.28, SD =  6.78) in the wait-list group. The findings revealed that the intervention group had increased knowledge of inappropriate touching recognition and personal safety. The say, tell, report, and WIST total skill scores also increased in the intervention group. These findings are promising and may pave the way for disseminating the program in Turkish preschools.

circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression.

Circular RNAs (circRNA) have been reported as regulators involved in hepatocellular carcinoma (HCC), but their mechanism of activity remains unknown. This study performed quantitative reverse-transcription polymerase chain reaction to determine if circNFATC3 was downregulated in 46 paired HCC tissues and cell lines. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, apoptotic, and transwell assay proved that circNFATC3 can inhibit hepatoma cell proliferation, apoptosis, and migration/invasion in vitro. Mouse xenograft assay demonstrated that circNFATC3 suppressed tumor size and weight and reduced lung metastasis in vivo, and vice versa. The RNA-seq results showed that NFATC3 itself was the most significantly differentially expressed gene when circNFATC3 was manipulated, and bioinformatics and luciferase reporter assays verified circNFATC3 regulated the expression of NFATC3 by interacting with the hsa-miR-548I. Additionally, it was also indicated that the level of NFATC3 was downregulated in HCC patients also and was significantly correlated with the staging and prognosis of HCC. Moreover, both circNFATC3 and NFATC3 were shown to inhibit the phosphorylation of JNK, c-Jun, AKT, and mTOR signaling pathways. Overall, the circNFATC3 can sponge miR-548I to protect NFATC3 itself, then it regulates hepatoma cell function via the JNK, c-Jun, AKT, and mTOR signaling pathways, and the circNFATC3 can be a tumor-repressor on HCC.

Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis.

Understanding how antibiotic-producing bacteria deal with highly reactive chemicals will ultimately guide therapeutic strategies to combat the increasing clinical resistance crisis. Here, we uncovered a distinctive self-defense strategy featured by a secreted oxidoreductase NapU to perform extracellularly oxidative activation and conditionally overoxidative inactivation of a matured prodrug in naphthyridinomycin (NDM) biosynthesis from Streptomyces lusitanus NRRL 8034. It was suggested that formation of NDM first involves a nonribosomal peptide synthetase assembly line to generate a prodrug. After exclusion and prodrug maturation, we identified a pharmacophore-inactivated intermediate, which required reactivation by NapU via oxidative C-H bond functionalization extracellularly to afford NDM. Beyond that, NapU could further oxidatively inactivate the NDM pharmacophore to avoid self-cytotoxicity if they coexist longer than necessary. This discovery represents an amalgamation of sophisticatedly temporal and spatial shielding mode conferring self-resistance in antibiotic biosynthesis from Gram-positive bacteria.

Modeling the competitive diffusions of rumor and knowledge and the impacts on epidemic spreading.

The interaction between epidemic spreading and information diffusion is an interdisciplinary research problem. During an epidemic, people tend to take self-protective measures to reduce the infection risk. However, with the diffusion of rumor, people may be difficult to make an appropriate choice. How to reduce the negative impact of rumor and to control epidemic has become a critical issue in the social network. Elaborate mathematical model is instructive to understand such complex dynamics. In this paper, we develop a two-layer network to model the interaction between the spread of epidemic and the competitive diffusions of information. The results show that knowledge diffusion can eradicate both rumor and epidemic, where the penetration intensity of knowledge into rumor plays a vital role. Specifically, the penetration intensity of knowledge significantly increases the thresholds for rumor and epidemic to break out, even when the self-protective measure is not perfectly effective. But eradicating rumor shouldn't be equated with eradicating epidemic. The epidemic can be eradicated with rumor still diffusing, and the epidemic may keep spreading with rumor being eradicated. Moreover, the communication-layer network structure greatly affects the spread of epidemic in the contact-layer network. When people have more connections in the communication-layer network, the knowledge is more likely to diffuse widely, and the rumor and epidemic can be eradicated more efficiently. When the communication-layer network is sparse, a larger penetration intensity of knowledge into rumor is required to promote the diffusion of knowledge.

Perceptions of Active Shooter Prevention and Preparation Strategies in Pennsylvania: Links to Self-Protective Behavior.

In this study, I document how members of the public perceive active shooter risk in their communities and their perceptions of the effectiveness of common efforts to prevent and respond to active shooters. I further investigate how news media exposure shapes these perceptions. I applied Protection Motivation Theory (PMT) to explore how perceptions and news media exposure might shape self-protective actions taken by individuals and their households. Data were obtained in 2019 from a cross-sectional, state-representative sample of 668 Pennsylvania adults who completed a web survey. Those who perceived higher community active shooter risk and those who felt community prevention and preparation efforts were effective were more likely to take self-protective steps themselves. Increased news exposure through apps, social media, family and friends was associated with increased perceived risk and effectiveness of prevention and preparation strategies. These results suggest that self-selected news and news through personal ties are linked to active shooter perceptions while other news mediums, like television or radio broadcasts, are not. News exposure was largely unrelated to self-protection. Those who felt community efforts were effective in prevention or preparation, however, were more likely to take self-protective actions. This finding indicates that community efforts may be more influential than news media in directing personal behavior.

Analysis of the mitigation strategies for COVID-19: From mathematical modelling perspective.

In this article, a mathematical model for the transmission of COVID-19 disease is formulated and analysed. It is shown that the model exhibits a backward bifurcation at R 0 = 1 when recovered individuals do not develop a permanent immunity for the disease. In the absence of reinfection, it is proved that the model is without backward bifurcation and the disease free equilibrium is globally asymptotically stable for R 0 < 1 . By using available data, the model is validated and parameter values are estimated. The sensitivity of the value of R 0 to changes in any of the parameter values involved in its formula is analysed. Moreover, various mitigation strategies are investigated using the proposed model and it is observed that the asymptomatic infectious group of individuals may play the major role in the re-emergence of the disease in the future. Therefore, it is recommended that in the absence of vaccination, countries need to develop capacities to detect and isolate at least 30% of the asymptomatic infectious group of individuals while treating in isolation at least 50% of symptomatic patients to control the disease.

Effects of heterogeneous self-protection awareness on resource-epidemic coevolution dynamics.

Recent studies have demonstrated that the allocation of individual resources has a significant influence on the dynamics of epidemic spreading. In the real scenario, individuals have a different level of awareness for self-protection when facing the outbreak of an epidemic. To investigate the effects of the heterogeneous self-awareness distribution on the epidemic dynamics, we propose a resource-epidemic coevolution model in this paper. We first study the effects of the heterogeneous distributions of node degree and self-awareness on the epidemic dynamics on artificial networks. Through extensive simulations, we find that the heterogeneity of self-awareness distribution suppresses the outbreak of an epidemic, and the heterogeneity of degree distribution enhances the epidemic spreading. Next, we study how the correlation between node degree and self-awareness affects the epidemic dynamics. The results reveal that when the correlation is positive, the heterogeneity of self-awareness restrains the epidemic spreading. While, when there is a significant negative correlation, strong heterogeneous or strong homogeneous distribution of the self-awareness is not conducive for disease suppression. We find an optimal heterogeneity of self-awareness, at which the disease can be suppressed to the most extent. Further research shows that the epidemic threshold increases monotonously when the correlation changes from most negative to most positive, and a critical value of the correlation coefficient is found. When the coefficient is below the critical value, an optimal heterogeneity of self-awareness exists; otherwise, the epidemic threshold decreases monotonously with the decline of the self-awareness heterogeneity. At last, we verify the results on four typical real-world networks and find that the results on the real-world networks are consistent with those on the artificial network.

Children's Knowledge and Skills Related to Self-Protection from Sexual Abuse in Central Java Indonesia.

The research aimed at assessing Muhammadiyah Elementary Schools' children's knowledge and skill in protecting themselves from CSA by analyzing them based on gender. It applied a quantitative method with descriptive statistical and inferential analysis designs. The samples amounted to 301 fifth-grade students from 10 Muhammadiyah Elementary Schools in Surakarta, Central Java, Indonesia. They were asked to complete the questionnaires of the "What If" Situation Test (WIST-III), adapted to an Indonesian context. When testing comprehension of touching situations, it was found that less than half of the respondents could identify appropriate touching situations (42%, M = 1.99, SD = ±1.04). There was a significant difference in the appropriate touching situation between males (M = 2.26, SD = ±1.9) and females (M = 1.76, SD = ±1.09). However, the ability to tell someone about the sexual abuse incident was very low, and a significant difference was found between females (p = .029, M = 1.7, SD = ± 2.3) and males (p = .029, M = 1.55, SD = ± 2.11). Only two per cent of the children achieved the maximum skills score. A CSA preventive program must be focused on building and developing children with regards to the skills to protect themselves from CSA by referring to cultural and Islamic values.

Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi.

Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional interest owing to their unique biomedical ramifications. The traditional discovery of new natural products that was mainly driven by bioactivity screening has now experienced a fresh new approach in the form of genome mining. Several bioinformatics tools have been continuously developed to detect potential biosynthetic gene clusters (BGCs) that are responsible for the production of SM. Although the principles underlying the computation of these tools have been discussed, the biological background is left underrated and ambiguous. In this review, we emphasize the biological hypotheses in BGC formation driven from the observations across genomes in bacteria and fungi, and provide a comprehensive list of updated algorithms/tools exclusively for BGC detection. Our review points to a direction that the biological hypotheses should be systematically incorporated into the BGC prediction and assist the prioritization of candidate BGC.

It takes two to self-disclose: Incremental theorists facilitate others' self-disclosure more than do entity theorists.

OBJECTIVE: We tested the prediction that incremental theorists are more likely to facilitate others' self-disclosure than are entity theorists. METHOD: We conducted three studies: (a) a field study that examined client's self-disclosure (N = 122; Mage  = 41.9, 67.8% woman; Israelis) during an intake interview with a professional therapist (N = 38; Mage  = 46.2, 84.20% woman; Israelis), (b) a survey of adults (N = 120; Mage  = 37.14, 57.6% female) who reported self-perceptions and behaviors during conversations and their perceptions of others' self-disclosure. In both studies participants reported their implicit theories, and (c) an experiment (N = 250; Mage  = 28.27, 56.6% female) in which participants whose implicit theories were manipulated reported their opening behaviors during a conversation and their perceptions of others' self-disclosure. RESULTS: Ones' incremental theory of personality was positively related to another's self-disclosure, to one's opening and disclosure-encouraging behaviors, and was negatively related to one's perceptions of others' self-protection tendency. Furthermore, one's opening behaviors and perceptions of others' self-protection tendencies mediated the effect of one's incremental theory on others' self-disclosure. CONCLUSION: Those who believe people can grow and change, can influence others to trust their personal information with them, even when the information is negative.