RESUMEN
The effective treatment of perianal fistulizing Crohn's disease is still a challenge. Local administration of mesenchymal stromal cells (MSCs) is becoming a part of accepted treatment options. However, as a fledgling technique, it still can be optimized. A new trend in translational research, which is in line with "One Health" approach, bases on exploiting parallels between naturally occurring diseases affecting humans and companion animals. Canine anal furunculosis (AF) has been indicated as condition analogous to human perianal Crohn's disease (pCD). This narrative review provides the first comprehensive comparative analysis of these two diseases based on the published data. The paper also outlines the molecular mechanisms of action of MSCs which are likely to have a role in modulating the perianal fistula niche in humans, and refers them to the current knowledge on the immunomodulatory properties of canine MSCs. Generally, the pathogenesis of both diseases shares main determinants such as the presence of genetic predispositions, dysregulation of immune response and the relation to intestine microbiota. However, we also identified many aspects which should be further specified, such as determining the frequency of true fistulas formation in AF patients, elucidating the role of TNF and Th17 pathway in the pathogenesis of AF, or clarifying the role of epithelial-to-mesenchymal transition phenomenon in the formation of canine fistulae. Nevertheless, the available data support the hypothesis that the results from testing cell therapies in dogs with anal furunculosis have a significant translational value in optimizing MSC transplants procedures in pCD patients.
Asunto(s)
Enfermedad de Crohn , Forunculosis , Trasplante de Células Madre Mesenquimatosas , Fístula Rectal , Humanos , Perros , Animales , Trasplante de Células Madre Mesenquimatosas/métodos , Enfermedad de Crohn/patología , Forunculosis/complicaciones , Fístula Rectal/terapia , Tratamiento Basado en Trasplante de Células y Tejidos/efectos adversosRESUMEN
Pathological scar tissues and normal skin tissues were differentiated by screening for differentially expressed genes in pathologic scar tissues via gene expression microarray. The differentially expressed gene data was analyzed by gene ontology and pathway analyses. There were 5001 up- or down-regulated genes in 2-fold differentially expressed genes, 956 up- or down-regulated genes in 5-fold differentially expressed genes, and 114 up- or down-regulated genes in 20-fold differentially expressed genes. Therefore, significant differences were observed in the gene expression in pathological scar tissues and normal foreskin tissues. The development of pathological scar tissues has been correlated to changes in multiple genes and pathways, which are believed to form a dynamic network connection.
Asunto(s)
Cicatriz/genética , Foliculitis/genética , Forunculosis/genética , Proteínas/genética , Adulto , Cicatriz/etiología , Cicatriz/metabolismo , Cicatriz/patología , Foliculitis/complicaciones , Foliculitis/metabolismo , Foliculitis/patología , Prepucio/citología , Prepucio/metabolismo , Forunculosis/complicaciones , Forunculosis/metabolismo , Forunculosis/patología , Perfilación de la Expresión Génica , Regulación de la Expresión Génica , Ontología de Genes , Humanos , Masculino , Redes y Vías Metabólicas/genética , Anotación de Secuencia Molecular , Análisis de Secuencia por Matrices de Oligonucleótidos , Proteínas/metabolismoRESUMEN
INTRODUCTION: Septic cavernous sinus thrombosis (CST) is a rare disease with many etiologies and a diffuse array of initial presentation leading to high mortality. CASE: A 25-year-old male with a history of a nasal furuncle presents with an acute onset of fixed and dilated pupils, bilateral exophthalmos, hemorrhagic chemosis, elevated intraocular pressures, restricted extraocular motility, and unresponsiveness. A retinal septic emboli in the left eye is present on dilated fundoscopic exam while an exudative retinal detachment is present in the right eye. MRI/MRV revealed extensive thrombosis of cavernous sinuses, distal sigmoid dural sinuses, and proximal internal jugular veins with associated cerebral edema and multifocal areas of venous infarction. Blood cultures grew Methicillin-resistant Staphylococcus aureus and the patient suffered multi-system organ failure. Despite treatment with full dose systemic anticoagulation and broad spectrum antibiotics the patient suffered a cardiopulmonary arrest and expired. COMMENT: The acuity of onset coupled with the multiple risk factors for septic cavernous sinus thrombosis in this patient led to a fulminant presentation of this disease and ultimate poor outcome.
Asunto(s)
Isquemia Encefálica/etiología , Trombosis del Seno Cavernoso/complicaciones , Forunculosis/complicaciones , Adulto , Resultado Fatal , Forunculosis/microbiología , Humanos , MasculinoRESUMEN
Thrombotic thrombocytopenic purpura (TTP) is an uncommon and potentially fatal syndrome which is due to either congenital or acquired deficiency of the ultra large von Willbrand's factor (ULVWF) cleavage protease. It is characterized by mechanical micro angiopathic hemolytic anemia, and organ dysfunctions.
Asunto(s)
Diabetes Mellitus Tipo 2/complicaciones , Endocarditis Bacteriana/complicaciones , Forunculosis/complicaciones , Púrpura Trombocitopénica Trombótica/etiología , Infecciones Estafilocócicas/complicaciones , Diagnóstico Diferencial , Endocarditis Bacteriana/diagnóstico , Forunculosis/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Púrpura Trombocitopénica Trombótica/diagnóstico , Infecciones Estafilocócicas/diagnósticoAsunto(s)
Bacteriemia/complicaciones , Desfibriladores Implantables/efectos adversos , Endocarditis Bacteriana/microbiología , Forunculosis/complicaciones , Embolia Pulmonar/microbiología , Adulto , Antibacterianos/uso terapéutico , Anticoagulantes/uso terapéutico , Bacteriemia/microbiología , Venas Braquiocefálicas , Quimioterapia Combinada , Ecocardiografía Transesofágica , Endocarditis Bacteriana/diagnóstico por imagen , Forunculosis/microbiología , Humanos , Maxilares , Venas Yugulares , Masculino , Nafcilina/uso terapéutico , Embolia Pulmonar/diagnóstico por imagen , Reoperación , Factores de Riesgo , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Trombosis de la Vena/diagnóstico por imagen , Warfarina/uso terapéuticoRESUMEN
We were presented with a teenage female who developed superior ophthalmic vein thrombosis and cavernous sinus thrombophlebitis after a 1-week history of a single acne-like lesion or furuncle at the anterior tip of the nose. She was managed aggressively with heparin and intravenous antibiotic. Signs and symptoms improved after 2 weeks of treatment, and she was discharged with an anticoagulant.
Asunto(s)
Trombosis del Seno Cavernoso/etiología , Ojo/irrigación sanguínea , Forunculosis/complicaciones , Infecciones Estafilocócicas/complicaciones , Trombosis de la Vena/etiología , Adolescente , Anticoagulantes/uso terapéutico , Trombosis del Seno Cavernoso/diagnóstico por imagen , Trombosis del Seno Cavernoso/tratamiento farmacológico , Cloxacilina/uso terapéutico , Progresión de la Enfermedad , Femenino , Estudios de Seguimiento , Forunculosis/tratamiento farmacológico , Forunculosis/microbiología , Heparina/uso terapéutico , Humanos , Nariz , Medición de Riesgo , Índice de Severidad de la Enfermedad , Infecciones Estafilocócicas/diagnóstico , Infecciones Estafilocócicas/tratamiento farmacológico , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Venas , Trombosis de la Vena/diagnóstico por imagen , Trombosis de la Vena/tratamiento farmacológicoRESUMEN
The 'soak and smear' regimen is a highly effective method for localised topical therapy employed by dermatologists for widespread inflammatory skin conditions. The regimen involves application of topical medication under occlusion after soaking in water. Complications from this treatment method are rare. We present a case of multiple, generalised methicillin-resistant Staphylococcus aureus (MRSA)-positive furuncles arising in a patient as an unexpected consequence of therapy. The case highlights an unanticipated risk of a commonly employed treatment amid an epidemic of MRSA in the community.
Asunto(s)
Eccema/tratamiento farmacológico , Forunculosis/complicaciones , Glucocorticoides/administración & dosificación , Staphylococcus aureus Resistente a Meticilina/efectos de los fármacos , Infecciones Estafilocócicas/complicaciones , Anciano , Antibacterianos/uso terapéutico , Clorhexidina/uso terapéutico , Clobetasol/administración & dosificación , Diagnóstico Diferencial , Doxiciclina/uso terapéutico , Forunculosis/diagnóstico , Forunculosis/tratamiento farmacológico , Humanos , Masculino , Mupirocina/uso terapéutico , Rifampin/uso terapéutico , Infecciones Estafilocócicas/diagnóstico , Infecciones Estafilocócicas/tratamiento farmacológico , Staphylococcus aureus/efectos de los fármacos , Resultado del Tratamiento , Agua/administración & dosificaciónRESUMEN
An outbreak of Staphylococcus aureus furuncles (boils) occurred among 26 members of a central Illinois high school football team. A total of 55 boils were reported with a diameter of induration ranging from 0.25 to 6 inches (mean = 1.25 inches). Eighty-nine percent of the boils were located on the extremities, and 70% were known to have developed following a bruise or break in the skin. The development of boils was associated with prior bruises and open wounds. Use of skin lubricant, elbow and forearm pads, whirlpool bath, and athletic tape were also associated with the development of boils, but were not judged to be causal. Rather, these factors most likely reflected attempts to protect areas of compromised skin which were at high risk of developing boils. Lack of hot water and soap for showering may have facilitated the occurrence of the outbreak by discouraging players from showering. Other variables examined, but excluded as important factors, were the sharing of football pads, the sharing of towels, the laundering of athletic clothes, and the position played on the football team.
Asunto(s)
Brotes de Enfermedades/epidemiología , Fútbol Americano , Forunculosis/epidemiología , Medicina Deportiva , Contusiones/complicaciones , Forunculosis/complicaciones , Forunculosis/transmisión , Humanos , Masculino , Pomadas , Medicina Deportiva/instrumentaciónRESUMEN
A seemingly trivial infection of the skin can lead to fulminant staphylococcal pneumonia and death. This case history describes the evolution of a fatal Staphylococcus aureus sepsis complicated by the development of multiple lung abscesses in a 17-year-old patient. A pre-existing cutaneous furuncle was the only identifiable cause. Early bacteraemic symptoms are described. Multiple cavitory lesions could be seen on a CAT-scan. The authors would like to stress the importance of early and adequate antibiotic treatment.
Asunto(s)
Forunculosis/complicaciones , Absceso Pulmonar/microbiología , Infecciones Estafilocócicas/microbiología , Adolescente , Resultado Fatal , Forunculosis/microbiología , Humanos , Absceso Pulmonar/diagnóstico por imagen , Masculino , Infecciones Estafilocócicas/diagnóstico por imagen , Tomografía Computarizada por Rayos XRESUMEN
Orbital inflammation secondary to sinus inflammation is a well known entity and has been widely reported. However, nasal furunculosis resulting in orbital inflammation is a rare occurrence. We present a case of a 2-year-old boy who developed multiple bilateral orbital abscesses secondary to nasal furunculosis. To our knowledge such a case has not been reported before.
Asunto(s)
Absceso/etiología , Forunculosis/complicaciones , Enfermedades Nasales/complicaciones , Enfermedades Orbitales/etiología , Infecciones Estafilocócicas , Absceso/diagnóstico , Absceso/terapia , Preescolar , Forunculosis/diagnóstico , Forunculosis/terapia , Humanos , Masculino , Enfermedades Nasales/diagnóstico , Enfermedades Nasales/terapia , Enfermedades Orbitales/diagnóstico , Enfermedades Orbitales/terapia , Infecciones Estafilocócicas/diagnóstico , Infecciones Estafilocócicas/terapiaRESUMEN
Treatment of anal furunculosis in dogs is often unsatisfactory and may be associated with significant recurrence and complications. This may be compounded by the simultaneous presence of colitis in affected animals. Clinical signs associated with colitis and anal furunculosis may be similar, including faecal tenesmus, dyschezia and haematochezia. To examine the incidence of concurrent anal furunculosis and colitis, colonic biopsies were collected from 18 dogs referred for treatment of anal furunculosis. Nine dogs (50 per cent) had a histopathological diagnosis of colitis. Clinical signs more indicative of colitis than anal furunculosis (increased frequency of defecation, mucus in faeces and diarrhoea) were not observed more frequently in dogs with confirmed colitis compared with those with furunculosis alone. Therefore, while an association between colitis and anal furunculosis may exist, clinical signs alone cannot be used as an indicator of the presence of colitis in cases of anal furunculosis. The authors recommend that colonic biopsies should be undertaken in all dogs presented with anal furunculosis. Whether specific treatment of colitis in dogs with histopathological evidence of colitis improves the outcome of treatment for anal furunculosis awaits further study.
Asunto(s)
Colitis/veterinaria , Enfermedades de los Perros/patología , Forunculosis/veterinaria , Animales , Colitis/complicaciones , Colitis/patología , Perros , Femenino , Forunculosis/clasificación , Forunculosis/complicaciones , Incidencia , Masculino , Índice de Severidad de la EnfermedadRESUMEN
BACKGROUND: A strong association has been observed between furuncles and Panton-Valentine leukocidin-producing Staphylococcus aureus. CASE REPORTS: Within one year, we cared for three men at the Cayenne hospital who had Staphylococcus aureus septicemia with severe pleuropulmonary involvement originating from furuncular lesions. The Staphylococcus aureus strains isolated from the skin lesions and from blood cultures produced Panton-Valentine leukocidin. CONCLUSION: These cases demonstrate the gravity of S. aureus septicemia in young patients with furunculosis. These cases are the first reported with severe S. aureus infections associated with Panton-Valentine leukocidin producing strains.
Asunto(s)
Forunculosis/complicaciones , Leucocidinas/biosíntesis , Sepsis/etiología , Infecciones Estafilocócicas/complicaciones , Staphylococcus aureus , Adolescente , Adulto , Dermatosis Facial/etiología , Forunculosis/microbiología , Humanos , Absceso Pulmonar/diagnóstico por imagen , Absceso Pulmonar/etiología , Masculino , Staphylococcus aureus/genética , Staphylococcus aureus/aislamiento & purificación , Tomografía Computarizada por Rayos XRESUMEN
AIM: To test clinical efficiency and immunocorrectives characteristics of polyoxidonium in patients with chronic bronchitis (CB) and chronic recurrent furunculosis. MATERIALS AND METHODS: 56 patients entered the trial; 13 with CB in remission, 22 with CB in exacerbation and 21 with chronic recurrent furunculosis. Clinical examinations and tests were made before polyoxidonium therapy and 2-3 days after it. Immunological tests consisted of determination of sub-population composition of peripheral blood lymphocytes, serum immunoglobulins and phagocytic activity of neutrophils. RESULTS: Polyoxidonium is an effective and safe immunocorrector. It has a strong influence on functional activity of blood phagocytic cells. CONCLUSION: Polyoxidonium treatment of CB and chronic recurrent furunculosis results in positive shifts in hematological and immunological indices. This allows to recommend it for treatment of acute and chronic infections.
Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Bronquitis/tratamiento farmacológico , Forunculosis/tratamiento farmacológico , Síndromes de Inmunodeficiencia/tratamiento farmacológico , Adolescente , Adulto , Antibacterianos/uso terapéutico , Antígenos CD/inmunología , Bronquitis/complicaciones , Bronquitis/inmunología , Enfermedad Crónica , Quimioterapia Combinada , Femenino , Estudios de Seguimiento , Forunculosis/complicaciones , Forunculosis/inmunología , Humanos , Síndromes de Inmunodeficiencia/etiología , Síndromes de Inmunodeficiencia/inmunología , Masculino , Persona de Mediana Edad , Fagocitosis/efectos de los fármacos , Fagocitosis/inmunología , Recurrencia , Federación de Rusia , Seguridad , Linfocitos T/inmunologíaRESUMEN
The author analyzes results of diagnostics and treatment of 152 patients with septic metastatic staphylococcal destruction of the lungs. Specific features of the clinical course of the disease are described. Under consideration are questions of the complex pathogenetic treatment of this group of patients by means of using antibiotic and immune therapy, fat emulsions (lipofundin), exchange plasmapheresis, ultraviolet irradiation of blood etc.
Asunto(s)
Endometritis/complicaciones , Forunculosis/complicaciones , Neumonía Estafilocócica/terapia , Infecciones Estafilocócicas/complicaciones , Infección de Heridas/complicaciones , Adulto , Anciano , Terapia Combinada , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neumonía Estafilocócica/etiologíaRESUMEN
The study of blood coagulation in 50 patients with complicated nasal furuncle using thromboelastogram indicated that such patients have hypercoagulation correctable by intravascular laser radiation. Thromboelastography proved a reliable objective technique in evaluation of blood coagulation this promoting a valid choice of therapeutic policy in complicated nasal furunculi.
Asunto(s)
Trastornos de la Coagulación Sanguínea/diagnóstico , Trastornos de la Coagulación Sanguínea/etiología , Forunculosis/complicaciones , Enfermedades Nasales/complicaciones , Tromboelastografía , Adolescente , Adulto , Anciano , Trastornos de la Coagulación Sanguínea/radioterapia , Femenino , Humanos , Terapia por Láser , Masculino , Persona de Mediana EdadRESUMEN
The metastatic origin of abscesses was established in 10 of 142 patients (7%) with acute pulmonary abscesses. The disease was observed to be of severe course, being accompanied by pleural and other complications in all the cases. Thirteen distinctive signs of metastatic abscesses were revealed which determine the curative methods. The main problem in the treatment of such patients is struggle against sepsis, correction of immune processes in the organism, sanitation of the abscess cavity through the tracheobronchial tree and liquidation of pleural complications.
Asunto(s)
Absceso Pulmonar/etiología , Infecciones por Pseudomonas/etiología , Infecciones Estafilocócicas/etiología , Aborto Séptico/complicaciones , Ántrax/complicaciones , Femenino , Forunculosis/complicaciones , Humanos , Absceso Pulmonar/terapia , Masculino , Otitis/complicaciones , Embarazo , Proctitis/complicaciones , Infecciones por Pseudomonas/terapia , Infecciones Estafilocócicas/terapiaRESUMEN
Among 370 patients with staphylococcic abscessing pneumonia in 55 secondary pulmonary involvement (14.8%) was noted. Acute hematogenic osteomyelitis was the most frequent cause of sepsis. The treatment of patients with secondary staphylociccic abscessing pneumonia is described. The mortality was 40 per cent.
Asunto(s)
Neumonía Estafilocócica , Adolescente , Niño , Femenino , Forunculosis/complicaciones , Humanos , Absceso Pulmonar/etiología , Masculino , Osteomielitis/complicaciones , Peritonitis/complicaciones , Neumonía Estafilocócica/complicaciones , Neumonía Estafilocócica/etiología , Infecciones Estafilocócicas/complicacionesRESUMEN
T-cell immunity was assessed in 111 patients with subleukemic myelosis. In such patients with large tumor mass and leukemia exacerbation the amount of immunocompetent cells and their functional activity were reduced more prominently. Association of infection and inflammation promoted aggravation of initial immune deficiency.
Asunto(s)
Forunculosis/inmunología , Leucemia Eritroblástica Aguda/inmunología , Infecciones del Sistema Respiratorio/inmunología , Linfocitos T/inmunología , Adulto , Anciano , Femenino , Forunculosis/complicaciones , Forunculosis/patología , Humanos , Leucemia Eritroblástica Aguda/complicaciones , Leucemia Eritroblástica Aguda/patología , Masculino , Persona de Mediana Edad , Infecciones del Sistema Respiratorio/complicaciones , Infecciones del Sistema Respiratorio/patologíaRESUMEN
Under analysis are etiology, clinical picture and diagnosis of a septic thrombosis of cavernous sinuses in 28 patients. The authors have shown the interrelationship between local manifestations of the disease, injuries of the brain and its sheaths and septic complications (abscessing pneumonia as the most severe of them). A scheme of the complex treatment of patients with thrombosis of the cavernous sinus is proposed. The leading role in this treatment is played by intracarotid infusion of antibiotics in combination with anticoagulant drugs, vasodilatatory agents and novocaine as well as the therapy of septic complications (abscesses of the face and hairy part of the head, meningoencephalitis, pneumonia).