Detalhe da pesquisa
1.
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis.
Mol Pharm
; 21(2): 864-872, 2024 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38134445
2.
The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0.
Int J Mol Sci
; 24(21)2023 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37958850
3.
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97.
Int J Mol Sci
; 24(7)2023 Mar 28.
Artigo
Inglês
| MEDLINE | ID: mdl-37047353
4.
Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties.
Molecules
; 27(4)2022 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35209087
5.
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4.
Molecules
; 27(5)2022 Mar 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35268783
6.
Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives.
Int J Mol Sci
; 22(12)2021 Jun 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34198620
7.
σ2 Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach.
Molecules
; 26(12)2021 Jun 19.
Artigo
Inglês
| MEDLINE | ID: mdl-34205334
8.
MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor.
Int J Mol Sci
; 21(9)2020 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32397184
9.
Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor.
BMC Cancer
; 19(1): 473, 2019 May 20.
Artigo
Inglês
| MEDLINE | ID: mdl-31109310
10.
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells.
Mol Pharm
; 16(8): 3361-3373, 2019 08 05.
Artigo
Inglês
| MEDLINE | ID: mdl-31265310
11.
Quantum Dot Based Luminescent Nanoprobes for Sigma-2 Receptor Imaging.
Mol Pharm
; 15(2): 458-471, 2018 02 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29226684
12.
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.
BMC Cancer
; 17(1): 51, 2017 01 13.
Artigo
Inglês
| MEDLINE | ID: mdl-28086830
13.
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1.
Pharmacol Res
; 117: 67-74, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28007569
14.
Novel and Selective Fluorescent σ2 -Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells.
Chembiochem
; 16(7): 1078-83, 2015 May 04.
Artigo
Inglês
| MEDLINE | ID: mdl-25757101
15.
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists.
Curr Med Chem
; 31(11): 1361-1403, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-37013427
16.
Investigation of σ receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines.
Bioorg Med Chem
; 21(7): 1865-9, 2013 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23415062
17.
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells.
Pharmacol Rep
; 75(6): 1588-1596, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37796435
18.
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach.
Sci Rep
; 13(1): 12798, 2023 08 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37550340
19.
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4'-piperidin]-1'-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques.
J Med Chem
; 66(6): 3798-3817, 2023 03 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36919956
20.
Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA receptors.
Res Sq
; 2023 Jan 27.
Artigo
Inglês
| MEDLINE | ID: mdl-36747738