Detalhe da pesquisa
1.
Advances in the discovery of activin receptor-like kinase 5 (ALK5) inhibitors.
Bioorg Chem
; 147: 107332, 2024 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-38581966
2.
Identification of thienopyrimidine derivatives tethered with sulfonamide and other moieties as carbonic anhydrase inhibitors: Design, synthesis and anti-proliferative activity.
Bioorg Chem
; 144: 107089, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38237393
3.
Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.
Bioorg Med Chem
; 56: 116596, 2022 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35033885
4.
New fluorinated diarylureas linked to pyrrolo[2,3-d]pyrimidine scaffold as VEGFR-2 inhibitors: Molecular docking and biological evaluation.
Bioorg Chem
; 127: 106006, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35820328
5.
Identification of a promising hit from a new series of pyrazolo[1,5-a]pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment.
Bioorg Chem
; 120: 105646, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35134645
6.
Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity.
Bioorg Chem
; 119: 105554, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34923243
7.
Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study.
J Enzyme Inhib Med Chem
; 37(1): 315-332, 2022 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-34955086
8.
Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells.
J Enzyme Inhib Med Chem
; 37(1): 2710-2724, 2022 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-36168121
9.
Discovery of potent thieno[2,3-d]pyrimidine VEGFR-2 inhibitors: Design, synthesis and enzyme inhibitory evaluation supported by molecular dynamics simulations.
Bioorg Chem
; 113: 105019, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34091286
10.
Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonists.
Bioorg Chem
; 114: 105079, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34174633
11.
Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancer.
Bioorg Chem
; 117: 105451, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34736137
12.
Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine-hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer.
J Enzyme Inhib Med Chem
; 36(1): 1290-1312, 2021 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-34187263
13.
Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors.
Bioorg Chem
; 101: 103961, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32480170
14.
Design, synthesis, biological evaluation and molecular modeling study of new thieno[2,3-d]pyrimidines with anti-proliferative activity on pancreatic cancer cell lines.
Bioorg Chem
; 94: 103472, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31813475
15.
Synthesis and in-vitro anti-proliferative evaluation of some pyrazolo[1,5-a]pyrimidines as novel larotrectinib analogs.
Bioorg Chem
; 94: 103458, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31785854
16.
Synthesis and antimicrobial evaluation of new halogenated 1,3-Thiazolidin-4-ones.
Bioorg Chem
; 95: 103517, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31884138
17.
Design, synthesis and biological evaluation of a new thieno[2,3-d]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breast cancer cell lines.
J Enzyme Inhib Med Chem
; 35(1): 1641-1656, 2020 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-32781854
18.
Design, synthesis and molecular modeling study of certain VEGFR-2 inhibitors based on thienopyrimidne scaffold as cancer targeting agents.
Bioorg Chem
; 83: 111-128, 2019 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30343204
19.
3D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: Design, synthesis and biological evaluation.
Bioorg Chem
; 89: 102988, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31146197
20.
Design, synthesis and molecular docking of novel pyrazolo[1,5-a][1,3,5]triazine derivatives as CDK2 inhibitors.
Bioorg Chem
; 92: 103239, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31513938