Detalhe da pesquisa
1.
Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers.
Bioorg Chem
; 144: 107105, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38219482
2.
Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations.
Bioorg Chem
; 140: 106789, 2023 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37611530
3.
Exploring the dual effect of novel 1,4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory symptoms.
Bioorg Chem
; 130: 106255, 2023 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36403336
4.
Apoptosis induction, PARP-1 inhibition, and cell cycle analysis of leukemia cancer cells treated with novel synthetic 1,2,3-triazole-chalcone conjugates.
Bioorg Chem
; 123: 105762, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35358822
5.
The effect of novel synthetic semicarbazone- and thiosemicarbazone-linked 1,2,3-triazoles on the apoptotic markers, VEGFR-2, and cell cycle of myeloid leukemia.
Bioorg Chem
; 127: 105968, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35728289
6.
Design, synthesis, docking, and anticancer evaluations of phthalazines as VEGFR-2 inhibitors.
Arch Pharm (Weinheim)
; 355(1): e2100278, 2022 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-34596910
7.
New quinoxalin-2(1H)-one-derived VEGFR-2 inhibitors: Design, synthesis, in vitro anticancer evaluations, in silico ADMET, and docking studies.
Arch Pharm (Weinheim)
; 355(7): e2200048, 2022 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-35437829
8.
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity.
Bioorg Med Chem
; 42: 116266, 2021 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34126285
9.
Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation.
Bioorg Chem
; 114: 105105, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34175720
10.
Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through inhibition of STAT3: synthesis and in silico mechanistic studies.
Mol Divers
; 25(1): 403-420, 2021 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-32830299
11.
Design, synthesis, and molecular docking studies of new [1,2,4]triazolo[4,3-a]quinoxaline derivatives as potential A2B receptor antagonists.
Mol Divers
; 25(1): 291-306, 2021 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-32166485
12.
Phthalazine-based VEGFR-2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations.
Arch Pharm (Weinheim)
; 354(11): e2100201, 2021 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-34411344
13.
N-Substituted-4-phenylphthalazin-1-amine-derived VEGFR-2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluation studies.
Arch Pharm (Weinheim)
; 354(3): e2000219, 2021 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-33197080
14.
Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine-2,4-dione derivatives as VEGFR-2 inhibitors.
Arch Pharm (Weinheim)
; 354(7): e2000491, 2021 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-33788290
15.
Synthesis, antimicrobial evaluation, DNA gyrase inhibition, and in silico pharmacokinetic studies of novel quinoline derivatives.
Arch Pharm (Weinheim)
; 354(2): e2000277, 2021 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-33078877
16.
Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5-[(4-chloro/2,4-dichloro)benzylidene]thiazolidine-2,4-dione derivatives as VEGFR-2 inhibitors.
Arch Pharm (Weinheim)
; 354(2): e2000279, 2021 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-33073374
17.
Pharmacophore-linked pyrazolo[3,4-d]pyrimidines as EGFR-TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies.
Arch Pharm (Weinheim)
; : e2100258, 2021 Aug 31.
Artigo
Inglês
| MEDLINE | ID: mdl-34467546
18.
In vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors.
Arch Pharm (Weinheim)
; 354(5): e2000449, 2021 May.
Artigo
Inglês
| MEDLINE | ID: mdl-33559320
19.
Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies.
Bioorg Chem
; 100: 103899, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32454390
20.
Synthesis and antibacterial evaluation of a novel library of 2-(thiazol-5-yl)-1,3,4-oxadiazole derivatives against methicillin-resistant Staphylococcus aureus (MRSA).
Bioorg Chem
; 94: 103364, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31668461