Detalhe da pesquisa
1.
Male germ cell-specific knockout of cholesterogenic cytochrome P450 lanosterol 14α-demethylase (Cyp51).
J Lipid Res
; 54(6): 1653-1661, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23509403
2.
On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.
J Lipid Res
; 54(4): 1033-43, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23284090
3.
Steroidal triterpenes of cholesterol synthesis.
Molecules
; 18(4): 4002-17, 2013 Apr 04.
Artigo
Inglês
| MEDLINE | ID: mdl-23558541
4.
Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome.
J Biol Chem
; 286(33): 29086-29097, 2011 Aug 19.
Artigo
Inglês
| MEDLINE | ID: mdl-21705796
5.
The anti-carcinogenic effect of statins in a rat model correlates with levels and synthesis of ubiquinone.
Biochem Biophys Res Commun
; 425(2): 348-52, 2012 Aug 24.
Artigo
Inglês
| MEDLINE | ID: mdl-22842579
6.
Circadian rhythm of cholesterol synthesis in mouse liver: a statistical analysis of the post-squalene metabolites in wild-type and Crem-knock-out mice.
Biochem Biophys Res Commun
; 408(4): 635-41, 2011 May 20.
Artigo
Inglês
| MEDLINE | ID: mdl-21531203
7.
Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis.
Drug Metab Dispos
; 39(1): 39-46, 2011 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-20952551
8.
Determination of reference genes for circadian studies in different tissues and mouse strains.
BMC Mol Biol
; 11: 60, 2010 Aug 16.
Artigo
Inglês
| MEDLINE | ID: mdl-20712867
9.
Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent.
Drug Metab Dispos
; 37(2): 375-85, 2009 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18971317
10.
CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver.
Biochem Biophys Res Commun
; 376(1): 206-10, 2008 Nov 07.
Artigo
Inglês
| MEDLINE | ID: mdl-18775413
11.
Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51).
Bioorg Med Chem
; 16(1): 209-21, 2008 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17964172
12.
Training in Systems Approaches for the Next Generation of Life Scientists and Medical Doctors.
Methods Mol Biol
; 1386: 73-86, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-26677180
13.
Mouse genotypes drive the liver and adrenal gland clocks.
Sci Rep
; 6: 31955, 2016 08 18.
Artigo
Inglês
| MEDLINE | ID: mdl-27535584
14.
Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis.
Sci Rep
; 6: 28462, 2016 06 23.
Artigo
Inglês
| MEDLINE | ID: mdl-27334049
15.
Strategies for structuring interdisciplinary education in Systems Biology: an European perspective.
NPJ Syst Biol Appl
; 2: 16011, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-28725471
16.
Cholesterogenic lanosterol 14alpha-demethylase (CYP51) is an immediate early response gene.
Endocrinology
; 146(12): 5321-31, 2005 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-16123160
17.
Statin-induced Myopathy and Ubiquinone Levels in Serum - Results from a Prospective, Observational Study.
Basic Clin Pharmacol Toxicol
; 117(2): 133-6, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-25627869
18.
Cholesterol, oxysterol, triglyceride, and coenzyme Q homeostasis in ALS. Evidence against the hypothesis that elevated 27-hydroxycholesterol is a pathogenic factor.
PLoS One
; 9(11): e113619, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25415378
19.
Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice.
PLoS One
; 8(7): e68031, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23844150
20.
Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal gland--involvement of cAMP-responsive element modulator in epigenetic regulation of Cyp17a1.
FEBS J
; 279(9): 1584-93, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21883931