Detalhe da pesquisa
1.
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Nature
; 535(7610): 148-52, 2016 07 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27362227
2.
Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
Bioorg Med Chem
; 25(24): 6479-6485, 2017 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29089257
3.
Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.
Biochemistry
; 55(15): 2269-77, 2016 Apr 19.
Artigo
Inglês
| MEDLINE | ID: mdl-27030275
4.
Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.
RNA
; 17(4): 687-96, 2011 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21335519
5.
Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.
J Am Chem Soc
; 134(25): 10313-6, 2012 Jun 27.
Artigo
Inglês
| MEDLINE | ID: mdl-22686940
6.
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.
Proc Natl Acad Sci U S A
; 106(8): 2549-53, 2009 Feb 24.
Artigo
Inglês
| MEDLINE | ID: mdl-19196969
7.
Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.
J Biol Chem
; 285(36): 27525-31, 2010 Sep 03.
Artigo
Inglês
| MEDLINE | ID: mdl-20522549
8.
Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling.
Elife
; 102021 03 23.
Artigo
Inglês
| MEDLINE | ID: mdl-33755016
9.
Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus.
J Am Chem Soc
; 132(35): 12182-4, 2010 Sep 08.
Artigo
Inglês
| MEDLINE | ID: mdl-20707374
10.
Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.
J Am Chem Soc
; 132(21): 7519-27, 2010 Jun 02.
Artigo
Inglês
| MEDLINE | ID: mdl-20455532
11.
Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.
Mol Cell Biol
; 27(6): 2384-97, 2007 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-17242201
12.
Intragenic suppressor mutations restore GTPase and translation functions of a eukaryotic initiation factor 5B switch II mutant.
Mol Cell Biol
; 27(5): 1677-85, 2007 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-17189426
13.
Correction: The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models.
Oncotarget
; 11(14): 1289, 2020 Apr 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32292577
14.
Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.
J Am Chem Soc
; 131(48): 17563-5, 2009 Dec 09.
Artigo
Inglês
| MEDLINE | ID: mdl-19911780
15.
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability.
Mol Biol Cell
; 17(11): 4632-44, 2006 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-16928960
16.
Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.
Nat Commun
; 9(1): 4508, 2018 10 30.
Artigo
Inglês
| MEDLINE | ID: mdl-30375388
17.
The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models.
Oncotarget
; 9(81): 35226-35240, 2018 Oct 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30443290
18.
Dual Allosteric Inhibition of SHP2 Phosphatase.
ACS Chem Biol
; 13(3): 647-656, 2018 03 16.
Artigo
Inglês
| MEDLINE | ID: mdl-29304282
19.
Reconstitution of yeast translation initiation.
Methods Enzymol
; 430: 111-45, 2007.
Artigo
Inglês
| MEDLINE | ID: mdl-17913637
20.
Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b.
Epigenetics Chromatin
; 10: 36, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28706564