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1.
Med Oral Patol Oral Cir Bucal ; 27(2): e150-e158, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-35218643

RESUMO

BACKGROUND: Survival of patients with oral squamous cell carcinoma (OSCC) is generally low, with the likelihood of locoregional recurrence or disease progression (LR/DP). Knowledge of prognostic factors for survival is key to achieving an understanding and increased survival. The present study aimed to identify prognostic factors for patients with OSCC, especially the presence of DNA from human papillomavirus (HPV). MATERIAL AND METHODS: Retrospective cohort study including 119 patients with OSCC treated at the National Cancer Institute in Mexico City (2009-2013). Clinical information was obtained from patient records including LR/DP. Formalin-fixed, paraffin-embedded tissues were obtained and used for detecting DNA from different types of HPV. Potential prognostic factors for Overall Survival (OS) were analyzed using the Cox proportional hazards model. RESULTS: After model adjustment, factors associated with longer OS were a pre-treatment platelet count above 400,000/mm3 (HR=0.09, p=0.026) and response to primary treatment (HR=0.26, p=0.001). HPV DNA was present in 23 (19.3%) of the patients and importantly, type 16 found in 19 of them. Although survival of HPV-positive patients was longer, difference was not significant. However, among patients with LR/DP, HPV positivity was significantly associated with increased survival (HR=0.23, p=0.034). Importantly, survival was significantly different for HPV-positive patients with LR/DP > 6 months (HR=0.20, p=0.002), had higher absolute lymphocyte count at start of treatment (HR=0.50, p=0.028) or had local rescue treatment (HR=0.24, p=0.019). CONCLUSIONS: Although HPV positivity was not associated with a longer OS of OSCC patients, a better prognosis was significantly associated with HPV positivity and recurring or progressing disease, particularly with HPV type 16.


Assuntos
Alphapapillomavirus , Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Neoplasias Bucais , Neoplasias Orofaríngeas , Infecções por Papillomavirus , Alphapapillomavirus/genética , Carcinoma de Células Escamosas/patologia , DNA Viral , Neoplasias de Cabeça e Pescoço/complicações , Humanos , Neoplasias Bucais/patologia , Recidiva Local de Neoplasia , Papillomaviridae/genética , Infecções por Papillomavirus/complicações , Infecções por Papillomavirus/diagnóstico , Prognóstico , Estudos Retrospectivos , Carcinoma de Células Escamosas de Cabeça e Pescoço/complicações
2.
Am J Infect Control ; 28(1): 21-4, 2000 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-10679133

RESUMO

BACKGROUND: The teaching of infection control is gradually being introduced at dental schools in Mexico. However, most practicing dentists have limited access to current infection control standards. Deficiencies of knowledge with regard to blood-borne pathogens such as HIV and hepatitis B virus may influence attitudes toward infected individuals and reduce compliance with infection control recommendations. OBJECTIVE: The purpose of this study was to assess (1) attitudes toward HIV-infected patients and hepatitis B virus-infected patients and (2) infection control knowledge and practices among dental practitioners in Mexico City. METHOD: A total of 196 dentists were interviewed by means of a questionnaire with Likert-type scales and open-ended questions (response rate, 86.1%). RESULTS: Most respondents had no previous social or professional contact with HIV-positive individuals. Nine percent indicated that they had knowingly treated HIV-positive patients. Perceived professional and moral obligations to treat HIV-positive patients were high. Thirty-five percent of the respondents perceived the risk of HIV infection as "considerable" to "very strong." The risk of hepatitis B infection was considered significantly higher than the risk of HIV infection (P <.01); however, 78% of the respondents had not been immunized against hepatitis B. Reported use of personal protective equipment was high. Most respondents used dry heat sterilization. The principal disinfectants used were quaternary ammonium compounds, bleach, and glutaraldehyde. Fifty-four percent of the respondents acknowledged that clinical precautions reduced occupational risks. CONCLUSIONS: This survey revealed contradictory attitudes toward HIV-positive individuals and limited understanding of infection control recommendations. Educational and regulatory efforts are needed to promote better adherence to current infection control standards.


Assuntos
Atitude do Pessoal de Saúde , Odontólogos/psicologia , Infecções por HIV/prevenção & controle , Conhecimentos, Atitudes e Prática em Saúde , Hepatite B/prevenção & controle , Controle de Infecções Dentárias/métodos , Controle de Infecções Dentárias/estatística & dados numéricos , Transmissão de Doença Infecciosa do Paciente para o Profissional , Adulto , Desinfetantes de Equipamento Odontológico , Feminino , Infecções por HIV/transmissão , Hepatite B/transmissão , Humanos , Masculino , México , Roupa de Proteção , Fatores de Risco , Esterilização/métodos , Inquéritos e Questionários , Precauções Universais
3.
Pract Odontol ; 10(12): 29-33, 1989 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-2700796

RESUMO

Remote as it once seemed that dental surgeons would some day be interested in introducing computers in their daily practice, the degree of motivation now increasingly impulsing dentists to apply this technology in their offices is indeed amazing. The object of this article is to offer some helpful information to those who are contemplating or have recently adopted the computer in their dental practice.


Assuntos
Alfabetização Digital , Microcomputadores , Administração da Prática Odontológica , Sistemas Computacionais , Registros Odontológicos , Humanos , Terminologia como Assunto
4.
Salud Publica Mex ; 43(6): 570-3, 2001.
Artigo em Espanhol | MEDLINE | ID: mdl-11816232

RESUMO

OBJECTIVE: To compare the sporicidal activity of benzalkonium chloride (BKC) with that of glutaraldehyde. MATERIAL AND METHODS: A comparative study was conducted at the microbiology laboratory of Facultad de Odontología, Universidad Nacional Autónoma de México. Bacillus subtilis ATCC 9372 spores were exposed to these germicides (1 spore x mL) on a 0.22 mm filter. After completing the contact time the spores were washed and the filters were incubated on nutrient agar for 72 h at 37 degrees C. RESULTS: BKC did not eliminate B. subtilis spores at the concentration used, not even after increasing contact time to 15 h (900-fold the recommended time). Two percent glutaraldehyde destroyed spores only after 10 h of contact. Urea and sodium chloride showed no sporicidal activity. CONCLUSIONS: The results confirm that BKC lacks sporicidal activity and confirm that this quaternary ammonium compound is not able to "sterilize" or "disinfect" medical and dental instruments.


Assuntos
Anti-Infecciosos Locais , Compostos de Benzalcônio , Detergentes , Desinfecção , Esterilização , Instrumentos Odontológicos , Glutaral , Humanos , Instrumentos Cirúrgicos , Fatores de Tempo
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