Detalhe da pesquisa
1.
N- and s-substituted Pyrazolopyrimidines: A promising new class of potent c-Src kinase inhibitors with prominent antitumor activity.
Bioorg Chem
; 145: 107228, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38422592
2.
Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by Docking Studies.
Int J Mol Sci
; 24(19)2023 Oct 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37834474
3.
Design and Synthesis of Benzene Homologues Tethered with 1,2,4-Triazole and 1,3,4-Thiadiazole Motifs Revealing Dual MCF-7/HepG2 Cytotoxic Activity with Prominent Selectivity via Histone Demethylase LSD1 Inhibitory Effect.
Int J Mol Sci
; 23(15)2022 Aug 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35955929
4.
Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability.
Bioorg Chem
; 111: 104835, 2021 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33798850
5.
Synthesis, antimicrobial evaluation, DNA gyrase inhibition, and in silico pharmacokinetic studies of novel quinoline derivatives.
Arch Pharm (Weinheim)
; 354(2): e2000277, 2021 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-33078877
6.
In vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors.
Arch Pharm (Weinheim)
; 354(5): e2000449, 2021 May.
Artigo
Inglês
| MEDLINE | ID: mdl-33559320
7.
Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies.
Bioorg Chem
; 100: 103899, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32454390
8.
Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1,2,3-triazole fragment that mimic quinazoline epidermal growth factor receptor inhibitors: Synthesis, antitumor and mechanistic analyses.
Bioorg Chem
; 103: 104133, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32745759
9.
The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase.
Bioorg Chem
; 99: 103781, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32222620
10.
Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects.
Bioorg Chem
; 101: 103992, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32554279
11.
Targeted potent antimicrobial benzochromene-based analogues: Synthesis, computational studies, and inhibitory effect against 14α-Demethylase and DNA Gyrase.
Bioorg Chem
; 105: 104387, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33130344
12.
Introducing of potent cytotoxic novel 2-(aroylamino)cinnamamide derivatives against colon cancer mediated by dual apoptotic signal activation and oxidative stress.
Bioorg Chem
; 101: 103953, 2020 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32474179
13.
Antimicrobial screening and pharmacokinetic profiling of novel phenyl-[1,2,4]triazolo[4,3-a]quinoxaline analogues targeting DHFR and E. coli DNA gyrase B.
Bioorg Chem
; 96: 103656, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32062449
14.
Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors.
J Enzyme Inhib Med Chem
; 35(1): 598-609, 2020 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-32009479
15.
S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors.
J Enzyme Inhib Med Chem
; 35(1): 733-743, 2020 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-32189526
16.
Novel 1,2,4-triazole derivatives: Design, synthesis, anticancer evaluation, molecular docking, and pharmacokinetic profiling studies.
Arch Pharm (Weinheim)
; 353(12): e2000170, 2020 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-32893368
17.
First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone deacetylase inhibitors and antitumor agents.
Bioorg Chem
; 92: 103262, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31518757
18.
Design, synthesis, molecular docking of new lipophilic acetamide derivatives affording potential anticancer and antimicrobial agents.
Bioorg Chem
; 76: 332-342, 2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29227917
19.
Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.
J Enzyme Inhib Med Chem
; 33(1): 1074-1088, 2018 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-29923425
20.
Synthesis, Biological Evaluation, and Molecular Docking of Novel Thiazoles and [1,3,4]Thiadiazoles Incorporating Sulfonamide Group as DHFR Inhibitors.
Chem Biodivers
; 15(9): e1800231, 2018 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-29956887