Detalhe da pesquisa
1.
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).
Bioorg Med Chem Lett
; 28(1): 6-10, 2018 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29169674
2.
Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes.
J Pharmacol Exp Ther
; 358(3): 413-22, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27353073
3.
Optimization of isoxazoline amide benzoxaboroles for identification of a development candidate as an oral long acting animal ectoparasiticide.
Bioorg Med Chem Lett
; 26(13): 3182-3186, 2016 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27210432
4.
Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide.
Bioorg Med Chem Lett
; 25(23): 5589-93, 2015 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26508546
5.
Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.
Antimicrob Agents Chemother
; 57(3): 1394-403, 2013 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-23295920
6.
Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novel benzoxaborole.
J Pharmacol Exp Ther
; 344(2): 436-46, 2013 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-23192653
7.
Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors.
J Pharmacol Exp Ther
; 347(3): 615-25, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24049062
8.
Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent.
Bioorg Med Chem Lett
; 23(6): 1680-3, 2013 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23411072
9.
Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents.
Bioorg Med Chem Lett
; 23(21): 5870-3, 2013 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24075731
10.
Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates.
Nat Microbiol
; 7(10): 1536-1546, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36065062
11.
Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application.
Bioorg Med Chem Lett
; 20(7): 2270-4, 2010 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20188549
12.
Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs.
ACS Infect Dis
; 6(2): 180-185, 2020 02 14.
Artigo
Inglês
| MEDLINE | ID: mdl-31876143
13.
Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.
ACS Infect Dis
; 6(2): 173-179, 2020 02 14.
Artigo
Inglês
| MEDLINE | ID: mdl-31876154
14.
Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.
Bioorg Med Chem Lett
; 19(8): 2129-32, 2009 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19303290
15.
In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate.
J Pharm Sci
; 96(10): 2622-31, 2007 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-17621679
16.
Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.
J Med Chem
; 49(15): 4447-50, 2006 Jul 27.
Artigo
Inglês
| MEDLINE | ID: mdl-16854048
17.
Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH.
J Med Chem
; 48(23): 7468-76, 2005 Nov 17.
Artigo
Inglês
| MEDLINE | ID: mdl-16279806
18.
UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species.
Org Lett
; 4(25): 4387-90, 2002 Dec 12.
Artigo
Inglês
| MEDLINE | ID: mdl-12465894
19.
Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery.
J Pharm Biomed Anal
; 70: 344-53, 2012 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-22687459
20.
Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.
FEBS Lett
; 586(19): 3410-4, 2012 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-22841723