Detalhe da pesquisa
1.
Exploring cyclopropylamine containing cyanopyrimidines as LSD1 inhibitors: Design, synthesis, ADMET, MD analysis and anticancer activity profiling.
Bioorg Chem
; 147: 107336, 2024 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-38636431
2.
Synthesis, in-Silico studies and biological evaluation of pyrimidine based thiazolidinedione derivatives as potential anti-diabetic agent.
Bioorg Chem
; 134: 106449, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36889200
3.
Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents.
Bioorg Chem
; 126: 105885, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35636128
4.
Synthesis, ADMET prediction and reverse screening study of 3,4,5-trimethoxy phenyl ring pendant sulfur-containing cyanopyrimidine derivatives as promising apoptosis inducing anticancer agents.
Bioorg Chem
; 104: 104282, 2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33010624
5.
Identification of novel selective Mtb-DHFR inhibitors as antitubercular agents through structure-based computational techniques.
Arch Pharm (Weinheim)
; 353(2): e1900287, 2020 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-31867798
6.
Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents.
Bioorg Med Chem
; 27(7): 1421-1429, 2019 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30827867
7.
Unveiling novel diphenyl-1H-pyrazole based acrylates tethered to 1,2,3-triazole as promising apoptosis inducing cytotoxic and anti-inflammatory agents.
Bioorg Chem
; 87: 667-678, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30953886
8.
Targeting malaria and leishmaniasis: Synthesis and pharmacological evaluation of novel pyrazole-1,3,4-oxadiazole hybrids. Part II.
Bioorg Chem
; 89: 102986, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31146198
9.
Structural comparison of Mtb-DHFR and h-DHFR for design, synthesis and evaluation of selective non-pteridine analogues as antitubercular agents.
Bioorg Chem
; 80: 319-333, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29986181
10.
Synthesis of novel benzimidazole acrylonitriles for inhibition of Plasmodium falciparum growth by dual target inhibition.
Arch Pharm (Weinheim)
; 351(1)2018 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-29227011
11.
Anti-proliferative and anti-malarial activities of spiroisoxazoline analogues of artemisinin.
Arch Pharm (Weinheim)
; : e1800192, 2018 Dec 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30537298
12.
Molecular interactions of bisphenols and analogs with glucocorticoid biosynthetic pathway enzymes: an in silico approach.
Toxicol Mech Methods
; 28(1): 45-54, 2018 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-28715929
13.
Molecular interactions of dioxins and DLCs with the xenosensors (PXR and CAR): An in silico risk assessment approach.
J Mol Recognit
; 30(12)2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-28639323
14.
Molecular interactions of dioxins and DLCs with the ketosteroid receptors: an in silico risk assessment approach.
Toxicol Mech Methods
; 27(2): 151-163, 2017 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-27997270
15.
Pharmacophore based virtual screening, synthesis and SAR of novel inhibitors of Mycobacterium sulfotransferase.
Bioorg Med Chem Lett
; 25(3): 701-7, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25541388
16.
Novel pyrazole-pyrazoline hybrids endowed with thioamide as antimalarial agents: their synthesis and 3D-QSAR studies.
J Enzyme Inhib Med Chem
; 30(4): 597-606, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25333767
17.
Structure based virtual screening of MDPI database: discovery of structurally diverse and novel DPP-IV inhibitors.
Bioorg Med Chem Lett
; 24(15): 3447-51, 2014 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24948564
18.
Effectiveness of estrogen and its derivatives over dexamethasone in the treatment of COVID-19.
J Biomol Struct Dyn
; 42(4): 1858-1874, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-37129196
19.
Quinoline: A versatile heterocyclic.
Saudi Pharm J
; 21(1): 1-12, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23960814
20.
Predicting the molecular mechanism-driven progression of breast cancer through comprehensive network pharmacology and molecular docking approach.
Sci Rep
; 13(1): 13729, 2023 08 22.
Artigo
Inglês
| MEDLINE | ID: mdl-37607964