RESUMO
The anti-implantation and mid-term abortifacient effects exhibited by administration of Inula viscosa leaf extracts, were studied in rats. The aqueous extract administered i.p. on day 1-6 of gestation, totally diminished fetal implantation and caused a significant (P<0.05) reduction in the number of corpora lutea and blood progesterone levels. Meanwhile, administration on day 13-15 of gestation exhibited mid-term abortion. Furthermore, petroleum ether and dichloromethane, but not methanol, extracts exhibited pronounced abortifacient effects. The results of this study are in agreement with the traditional reputation of this plant as abortifacient. Further, the plant possesses anti-implantational and luteolytic effects.
Assuntos
Abortivos/farmacologia , Magnoliopsida/química , Extratos Vegetais/farmacologia , Animais , Corpo Lúteo/efeitos dos fármacos , Implantação do Embrião/efeitos dos fármacos , Feminino , Inula , Masculino , Extratos Vegetais/química , Extratos Vegetais/toxicidade , Folhas de Planta/química , Folhas de Planta/toxicidade , Gravidez , Progesterona/sangue , RatosRESUMO
Two cases of clear cell sarcoma of tendons and aponeuroses, one with prominent melanogenesis, are reported. One tumour arose in the left buttock of a young male and the other in the left fourth toe of a young female. Both had a rapid fatal course with local and distant metastases. Electron microscopy shows melanosomes in one case, suggesting a melanotic origin.