Increased irisin versus reduced fibroblast growth factor1 (FGF1) in relation to adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.

Background Irisin and fibroblast growth factor 1 (FGF1) are intricately involved in metabolic syndrome (MetS) and prediabetes (preDM) pathophysiology. This study aimed to compare and correlate irisin and FGF1 plasma levels, adiposity, atherogenicity and hematological indices in 29 normoglycemic MetS and 30 newly diagnosed drug naive prediabetic (PreDM) MetS patients vs. 29 lean and normoglycemic controls. Materials and methods Irisin and FGF1 plasma levels were measured using colorimetric assays. Intergroup comparisons were conducted by analysis of variance (ANOVA). Spearman's rank correlation was also examined. Results The mean circulating irisin levels (ng/mL) were significantly higher in the normoglycemic (but not prediabetic) MetS group (p < 0.01), while the mean circulating FGF1 levels (pg/mL) were markedly lower in the prediabetic (but not normoglycemic) MetS group (p < 0.05). Of note unlike FGF1, irisin in the MetS (both normoglycemic and prediabetic;N=59) groups correlated significantly and positively with each of waist circumference (WC), hip circumference (HC), body mass index (BMI), body adiposity index (BAI) and high-density lipoprotein-cholesterol (HDL-C) but not the non-HDL-C. Distinctively MetS-irisin negatively associated with the non-HDL-C/HDL-C ratio, total cholesterol (TC)/HDL-C ratio and the low-density lipoprotein-cholesterol (LDL-C)/HDL-C ratio, but positively with the red cell distribution width (RDW). In the same pool of 59 MetS reruits; Neither biomarker had a relationship with the visceral adiposity index (VAI), the lipid accumulation product (LAP), the conicity index (CI), the waist-hip ratio (WHR), the waist-to-height ratio (WHtR), the blood ratios or the atherogenicity index of plasma (AIP). Conclusions As any potential molecular crosstalk of irisin and FGF1 in MetS or its related dysregularities cannot be ruled out; Conversely the utility of irisin and FGF1 as surrogate prognostic biomarkers and putative pharmacotherapeutic targets in the predtion/prevention/management of diabetes and MetS is strongly suggested.

Proportional correlates of adipolin and cathepsin S in metabolic syndrome patients with and without prediabetes.

BACKGROUND: Adipolin and cathepsin S are intricately involved in pathophysiology of metabolic syndrome (MetS) and prediabetes (PreDM). AIMS & METHODS: This cross-sectional study aimed to compare and correlate between these metabolic biomarkers as well as between them and adiposity, atherogenicity and hematological indices in MetS patients. Our cross-sectional study involved recruiting 29 normoglycemic MetS, 30 newly diagnosed drug naïve PreDM-MetS patients versus 29 lean, healthy and normoglycemic controls. RESULTS: Adipolin and cathepsin S plasma levels were significantly higher in both MetS (normoglycemic and PreDM) groups vs. healthy controls. Evidently proportional adipolin-cathepsin S association was markedly signified in 59 MetS participants (normoglycemic and PreDM). Distinctively unlike adipolin, inverse cathepsin S-diastolic blood pressure (DBP) but direct cathepsin S-monocyte count and its monocyte -to- lymphocyte ratio cross-correlated were marked. Notably unlike cathepsin S, adipolin was positively associated with each of FPG, A1C and TG, visceral adiposity index, lipid accumulation product and atherogenic index of plsama in the MetS pool of participants (N = 59). CONCLUSIONS: Given the intergroup discrepancies in adiposity, atherogenicity indices and their correlations (as well as hematological indices) with biomarkers; this cross-sectional study cannot rule out either biomarker as an associative predictor or as a surrogate indicator and putative prognostic tool for the prediction/prevention and treatment of metabolism dysregularities.

Proportional correlates of cystatin-C with pentraxin-3, visceral adiposity index and atherogenicity index of plasma but not blood indices in metabolic syndrome patients with and without prediabetes.

Background Pentraxin-3 (PXT-3) and cystatin-C (Cys-C) are robustly related with central obesity and insulin resistance in prediabetes/metabolic syndrome (preDM-MetS). Materials and methods This cross-sectional study aimed to compare and correlate PXT-3 and Cys-C plasma levels in 29 normoglycemic MetS patients, 30 newly diagnosed drug naive preDM-MetS cases vs. 29 normoglycemic lean controls. Results Unlike PXT-3; Cys-C level was significantly higher in normoglycemic MetS (but not preDM-MetS) vs. healthy controls. Except for fasting blood glucose (FBG) and HbA1c; no further intergroup discrepancy could be identified between the MetS arms. Adiposity indices [body mass index (BMI), waist circumference (WC), hip circumference (HC), waist/height ratio (WHtR), body adiposity index (BAI) and lipid accumulation product (LAP) but not conicity index (CI)], atherogenicity index of plasma (AIP) (but not non-high density lipoprotein-cholesterol (nonHDL)-C, non-HDL-C/HDL-C ratio or total cholesterol (TC)/HDL-C ratio) or any of blood indices were substantially higher in both MetS (normoglycemic and preDM) groups vs. controls. Low density lipoprotein (LDL)-C/HDL-C ratio, visceral adiposity index (VAI) and WHR were exceptionally greater in MetS-preDM vs. controls. Marked proportional PTX-3-Cys-C correlation was noted in 59 MetS participants (normoglycemic and preDM). PTX-3 (but not Cys-C) correlated proportionally with each of neutrophils, monocyte/lymphocyte ratio and neutrophil/lymphocyte ratio but inversely with the lymphocyte count. Substantially, Cys-C (but not PXT-3) positively associated with both VAI and AIP but inversely with HDL-C. Neither biomarker in MetS pool had relations with red blood cell distribution width-coefficient of variation (RDW-CV%), BMI, WC, HC, CI, WHR, WHtR, BAI, LAP, non-HDL-C, ratios of non-HDL-C/HDL-C, LDL-C/HDL-C or TC/HDL-C. Conclusion PXT-3 and Cys-C can be surrogate prognostic/diagnostic biomarkers or putative MetS therapy targets.

Cross-sectional correlates of nesfatin and lipopolysaccharide binding protein in metabolic syndrome patients with and without prediabetes.

Background Metabolic syndrome (MetS) and prediabetes (preDM) have crosslinked pathophysiologies with central obesity and insulin resistance (IR). This study aimed to compare and correlate nesfatin and lipopolysaccharide binding protein (LBP) plasma levels, adiposity, atherogenicity and hematological indices between non-diabetic MetS, newly diagnosed drug naive pre-diabetic MetS patients vs. normoglycemic lean controls. Materials and methods In a cross-sectional study, 29 apparently healthy controls, 29 non-diabetic MetS subjects and 30 preDM-MetS patients were recruited. Results The LBP level (ng/mL) was substantially higher in both MetS (non- and pre-diabetic) groups compared to healthy controls. In contrast, circulating level of nesfatin (pg/mL) was lower, though not significantly; in both pre-diabetic and non-diabetic MetS patients compared to lean normoglycemic controls. No correlation was found between nesfatin and LBP in MetS pool (n = 59). Remarkably unlike blood indices; adiposity indices [body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height (WHtR) ratio, hip circumference (HC), body adiposity index (BAI), visceral adiposity index (VAI), lipid accumulation product (LAP) but not conicity index (CI)], atherogenicity indices [(atherogenicity index of plasma (AIP = Log10(TG/HDL-C ratio)), low density lipoprotein cholesterol to high density lipoprotein cholesterol ratio (LDL-C/HDL-C) and non-high density lipoprotein cholesterol (non-HDL-C)] were substantially higher in both MetS (non- and pre-diabetic) groups vs. those of controls. Exceptionally pronounced and proportional nesfatin-DBP and LBP-BAI correlations were identified in total MetS pool (both non-diabetic and pre-diabetic). Conclusions Nesfatin and LBP can be potential targets and surrogate biomarkers to use as putative prognostic/predictive tools for the prevention and treatment for MetS and related disorders.