Examining the Clinical Prognosis of Critically Ill Patients with COVID-19 Admitted to Intensive Care Units: A Nationwide Saudi Study.

Backgroundand Objectives: COVID-19 is a novel infectious disease caused by a single-stranded RNA coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to conduct a nationwide multicenter study to determine the characteristics and the clinical prognostic outcome of critically ill COVID-19 patients admitted to intensive care units (ICUs). Materials and Methods: This is a nationwide cohort retrospective study conducted in twenty Saudi hospitals. Results: An analysis of 1470 critically ill COVID-19 patients demonstrated that the majority of patients were male with a mean age of 55.9 ± 15.1 years. Most of our patients presented with a shortness of breath (SOB) (81.3%), followed by a fever (73.7%) and a cough (65.1%). Diabetes and hypertension were the most common comorbidities in the study (52.4% and 46.0%, respectively). Multiple complications were observed substantially more among non-survivors. The length and frequency of mechanical ventilation use were significantly greater (83%) in the non-survivors compared with the survivors (31%). The mean Sequential Organ Failure Assessment (SOFA) score was 6 ± 5. The overall mortality rate of the cohort associated with patients that had diabetes, hypertension and ischemic heart disease was 41.8%. Conclusion: Age; a pre-existing medical history of hypertension, diabetes and ischemic heart disease; smoking cigarettes; a BMI ≥ 29; a long mechanical ventilation and ICU stay; the need of ventilatory support; a high SOFA score; fungal co-infections and extracorporeal membrane oxygenation (ECMO) use were key clinical characteristics that predicted a high mortality in our population.

Exploring the Rise of E-cigarette Use Among Male Adolescents in Al-Ahsa, Saudi Arabia: Prevalence, Patterns, and Influencing Factors.

BACKGROUND: The rising prevalence of electronic cigarette (E-cigarette) use among adolescents is a major public health concern. This study investigates the prevalence of E-cigarette use among male adolescents in Al-Ahsa, Saudi Arabia, and explores associated factors. METHODOLOGY: A cross-sectional study was conducted from December 2022 to April 2023, involving 476 male students aged 12 to 19. Data were collected through structured questionnaires, covering sociodemographic information, E-cigarette usage patterns, reasons for use, sources of acquisition, awareness of nicotine content, and perceptions of harm. Statistical analysis was performed using SPSS 25 (IBM Corp., Armonk, NY), with significance set at p < 0.05. RESULTS: The study revealed a prevalence of 17.4% E-cigarette use among participants, with 12.6% using E-cigarettes exclusively and 4.8% concurrently with traditional tobacco cigarettes. Key findings included initiation as early as age eight, sustained and frequent use, and motivations including peer influence (61.4%), curiosity (31.3%), and flavored options (26.5%). Online platforms (34.9%) and shopping malls (28.9%) were the primary sources of E-cigarette acquisition. Most participants were aware of the nicotine content (84.3%) and believed E-cigarettes were harmful (86.7%). Importantly, 69.9% expressed intentions to quit, with 44.6% planning to do so within 30 days. Significant associations were found between E-cigarette use, education level, and having friends who smoke. CONCLUSION: This study highlights the prevalence of E-cigarette use among male adolescents in Al-Ahsa, Saudi Arabia, and identifies peer influence, curiosity, and appealing flavors as driving factors. Targeted prevention and intervention programs, along with regulatory efforts to restrict access, are urgently needed to address this growing public health issue. Increasing awareness of E-cigarette risks and providing cessation support are vital steps towards mitigating E-cigarette use among Saudi male adolescents.

Peripheral Gangrene as the Initial Presentation of Systemic Lupus Erythematosus in Emergency Department.

Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease. Among the cutaneous manifestations of SLE, digital gangrene is considered to be very rare. This complication, which may lead to severe ischemic necrosis and amputation, is suggested to be the result of poor perfusion that is usually caused by vasculitis, vasospasm, thromboembolism, or atherosclerosis. Digital gangrene is seen mostly at a late stage of the disease proposing that a long history of SLE is a considered risk factor. Only 0.2% of patients with SLE presented initially as digital necrosis. This is a case report of a 20-year-old Saudi female who presented to the emergency room primarily with acute painful localized dry digital gangrene associated with bilateral lower limbs petechial rash. Her medical history was not suggestive of autoimmune diseases. Serology was positive for SLE. A diagnosis of SLE, lupus nephritis, and vasculitis has been established clinically and serologically. The patient adequately responded to rituximab and steroids as a medical therapy. To our knowledge, cases of acute peripheral gangrene as the initial and only presentation of SLE have rarely been documented in Emergency Medicine.

Assessment of picture archiving and communication system (PACS) at three of ministry of health hospitals in Riyadh region - Content analysis.

BACKGROUND: Picture archiving and communication system (PACS) are management information systems used for distributing, viewing and archiving digital images by integrating different types of modalities through communication networks. PACS have many advantages that can lead to improving health care quality. PACS has been widely used in hospitals in Saudi Arabia for the past 10 years. However, an extensive review of literature in the field of PACS, among physicians and radiologists in Saudi Arabia, showed lack of local studies of this costly and newly implemented technology. Therefore, this assessment is very important to provide an insightful study of PACS in Saudi Arabia to provide proper recommendations for the PACS projects implementation nationwide. OBJECTIVES: The objectives of this study are to, firstly, assess the perceived benefits of PACS among physicians and radiologists specifically in quality of care, secondly, assess the perceived challenges of PACS implementation and adoption inside and outside the radiology department, and thirdly, to compare between physicians' and radiologists' perceptions toward PACS. METHODS: A cross-sectional descriptive study at three of Ministry of Health (MOH) Hospitals in the Riyadh region, Saudi Arabia. The researchers used two separate surveys questionnaires, for administration to the physicians and radiologists at the three hospitals. Apart from the questionnaire, included is feedback as responses to open-ended questions. Content analysis was used to analyze the feedback under two themes: benefits or challenges. RESULTS: The response rate was 46% (84/183) physicians and 88% (15/17) radiologists have participated in this study. The result showed that 70% physicians' views affirms that PACS improved physicians' efficiency. On the other hand, all radiologists who responded affirmed that PACS improved efficiency. For questions on the ability to make decisions, 69% of views have affirmed that PACS improved physician's abilities to make decisions regarding patient care. Using PACS has led to a reduction in patients' length of stay in hospital (LOS) question, 79% of total views were positive. In contrast, only 18% of physicians talked about PACS positively in summary views and 82% talked about the challenges of PACS whereas 20% of radiologists talked about PACS positively. CONCLUSIONS: The results in the present study conclude that PACS was well perceived due to its numerous benefits among physicians and radiologists. However, radiologists showed more focus on the benefits of PACS than physicians. The main disadvantages are that PACS has resulted in difficulty in finding images, recurrent downtime and insufficient training.

Galectins in cancer: carcinogenesis, diagnosis and therapy.

A major breakthrough in the field of medical oncology has been the discovery of galectins and their role in cancer development, progression and metastasis. In this review article we have condensed the results of a number of studies published over the past decade in an effort to shed some light on the unique role played by the galectin family of proteins in neoplasia, and how this knowledge may alter the approach to cancer diagnosis as well as therapy in the future. In this review we have also emphasized the potential use of galectin inhibitors or modulators in the treatment of cancer and how this novel treatment modality may affect patient outcomes in the future. Based on current pre-clinical models we believe the use of galectin inhibitors/modulators will play a significant role in cancer treatment in the future. Early clinical studies are underway to evaluate the utility of these promising agents in cancer patients.