1.
Bioorg Med Chem
; 22(17): 4955-60, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25047939
RESUMO
The bioactive metabolite sphingosine-1-phosphate (S1P), a product of sphingosine kinases (SphKs), mediates diverse biological processes such as cell differentiation, proliferation, survival and angiogenesis. A fluorinated analogue of S1P receptor agonist has been synthesized by utilizing a ring opening reaction of oxacycles by a lithiated difluoromethylphosphonate anion as the key reaction. In vitro activity of this S1P analogue is also reported.