Detalhe da pesquisa
1.
4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis.
Bioorg Med Chem Lett
; 27(22): 5014-5021, 2017 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29032026
2.
Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein.
Antimicrob Agents Chemother
; 57(7): 3250-61, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23629699
3.
PTC124 targets genetic disorders caused by nonsense mutations.
Nature
; 447(7140): 87-91, 2007 May 03.
Artigo
Inglês
| MEDLINE | ID: mdl-17450125
4.
Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties.
Mol Cancer Ther
; 18(1): 3-16, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30352802
5.
Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria.
J Med Chem
; 61(10): 4456-4475, 2018 05 24.
Artigo
Inglês
| MEDLINE | ID: mdl-29727185
6.
Safety, tolerability, and pharmacokinetics of PTC124, a nonaminoglycoside nonsense mutation suppressor, following single- and multiple-dose administration to healthy male and female adult volunteers.
J Clin Pharmacol
; 47(4): 430-44, 2007 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-17389552
7.
Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform.
PLoS One
; 11(12): e0168366, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27992500
8.
Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy.
J Med Chem
; 59(13): 6070-85, 2016 07 14.
Artigo
Inglês
| MEDLINE | ID: mdl-27299569
9.
Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.
Science
; 345(6197): 688-93, 2014 Aug 08.
Artigo
Inglês
| MEDLINE | ID: mdl-25104390
10.
Selective synthesis of 1-substituted 4-chloropyrazolo[3,4-d]pyrimidines.
Org Lett
; 15(8): 1882-5, 2013 Apr 19.
Artigo
Inglês
| MEDLINE | ID: mdl-23574146
11.
Correction to Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-Negative Bacteria.
J Med Chem
; 61(20): 9394, 2018 Oct 25.
Artigo
Inglês
| MEDLINE | ID: mdl-30351051