Detalhe da pesquisa
1.
Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo.
Cell Mol Life Sci
; 81(1): 224, 2024 May 20.
Artigo
Inglês
| MEDLINE | ID: mdl-38769196
2.
GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice.
PLoS Pathog
; 15(1): e1007520, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30608982
3.
Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions.
Acta Neuropathol
; 139(3): 527-546, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31673874
4.
Diverse functions of the prion protein - Does proteolytic processing hold the key?
Biochim Biophys Acta Mol Cell Res
; 1864(11 Pt B): 2128-2137, 2017 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-28693923
5.
Inducing prion protein shedding as a neuroprotective and regenerative approach in pathological conditions of the brain: from theory to facts.
Neural Regen Res
; 18(9): 1869-1875, 2023 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-36926701
6.
α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies.
Transl Neurodegener
; 12(1): 12, 2023 03 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36915212
7.
The prion protein and its ligands: Insights into structure-function relationships.
Biochim Biophys Acta Mol Cell Res
; 1869(6): 119240, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35192891
8.
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies.
Sci Adv
; 7(48): eabj1826, 2021 Nov 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34818048
9.
Pharmacological inactivation of the prion protein by targeting a folding intermediate.
Commun Biol
; 4(1): 62, 2021 01 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33437023
10.
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Nat Neurosci
; 24(11): 1522-1533, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34675436
11.
Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation.
Mol Neurobiol
; 57(6): 2812-2829, 2020 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-32367491
12.
Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake.
J Extracell Vesicles
; 9(1): 1809065, 2020 Aug 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32944194
13.
Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.
Neuron
; 99(6): 1155-1169.e9, 2018 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-30174115
14.
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.
Mol Neurodegener
; 13(1): 18, 2018 04 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29625583
15.
Misfolding leads the way to unraveling signaling pathways in the pathophysiology of prion diseases.
Prion
; 10(6): 434-443, 2016 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27870599
16.
Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice.
Sci Rep
; 6: 24970, 2016 04 27.
Artigo
Inglês
| MEDLINE | ID: mdl-27117504
17.
Shedding light on prion disease.
Prion
; 9(4): 244-56, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26186508
18.
The sheddase ADAM10 is a potent modulator of prion disease.
Elife
; 42015 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-25654651
19.
Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration.
FEBS J
; 280(18): 4338-47, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23413979
20.
Proteolytic processing of the prion protein in health and disease.
Am J Neurodegener Dis
; 1(1): 15-31, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-23383379