Detalhe da pesquisa
1.
Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-34551979
2.
A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation.
J Biol Chem
; 295(46): 15650-15661, 2020 11 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32893190
3.
Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation.
J Biol Chem
; 294(18): 7245-7258, 2019 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30858177
4.
Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1).
Am J Physiol Cell Physiol
; 314(3): C289-C296, 2018 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29167151
5.
Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer.
Mol Pharmacol
; 93(3): 208-215, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29326243
6.
Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation.
Am J Physiol Cell Physiol
; 312(4): C517-C526, 2017 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28122733
7.
Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.
Biochim Biophys Acta Biomembr
; 1859(11): 2193-2202, 2017 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-28802835
8.
Physiological role of FolD (methylenetetrahydrofolate dehydrogenase), FchA (methenyltetrahydrofolate cyclohydrolase) and Fhs (formyltetrahydrofolate synthetase) from Clostridium perfringens in a heterologous model of Escherichia coli.
Microbiology (Reading)
; 162(1): 145-155, 2016 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-26531681
9.
One-carbon metabolic pathway rewiring in Escherichia coli reveals an evolutionary advantage of 10-formyltetrahydrofolate synthetase (Fhs) in survival under hypoxia.
J Bacteriol
; 197(4): 717-26, 2015 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25448816
10.
Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency.
J Clin Invest
; 134(8)2024 Feb 20.
Artigo
Inglês
| MEDLINE | ID: mdl-38376944
11.
Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice.
Elife
; 122023 Dec 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38153418
12.
Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review.
Exp Hematol Oncol
; 12(1): 60, 2023 Jul 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37422676
13.
Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: Clinical efficacy and correlative analyses.
Res Sq
; 2023 Feb 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36865338
14.
Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer.
J Hematol Oncol
; 15(1): 70, 2022 05 23.
Artigo
Inglês
| MEDLINE | ID: mdl-35606824
15.
Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition.
Cell Rep
; 41(11): 111825, 2022 12 13.
Artigo
Inglês
| MEDLINE | ID: mdl-36516770
16.
High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster.
Nat Med
; 28(3): 468-471, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35256801
17.
Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations.
Elife
; 112022 08 30.
Artigo
Inglês
| MEDLINE | ID: mdl-36040792
18.
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Cell Rep
; 36(4): 109421, 2021 07 27.
Artigo
Inglês
| MEDLINE | ID: mdl-34320342
19.
Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes.
J Clin Invest
; 130(2): 582-589, 2020 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31961337
20.
The thrombopoietin mimetic JNJ-26366821 increases megakaryopoiesis without affecting malignant myeloid proliferation.
Leuk Lymphoma
; 61(10): 2453-2465, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32578476