Detalhe da pesquisa
1.
Skeletal Editing Approach to Bridge-Functionalized Bicyclo[1.1.1]pentanes from Azabicyclo[2.1.1]hexanes.
J Am Chem Soc
; 145(20): 10960-10966, 2023 May 24.
Artigo
Inglês
| MEDLINE | ID: mdl-37145091
2.
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
J Pharmacol Exp Ther
; 372(3): 339-353, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31818916
3.
D3R grand challenge 4: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies.
J Comput Aided Mol Des
; 34(2): 99-119, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31974851
4.
D3R Grand Challenge 3: blind prediction of protein-ligand poses and affinity rankings.
J Comput Aided Mol Des
; 33(1): 1-18, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30632055
5.
Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8.
J Pharmacol Exp Ther
; 357(2): 394-414, 2016 May.
Artigo
Inglês
| MEDLINE | ID: mdl-26989142
6.
Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists.
Bioorg Med Chem Lett
; 26(2): 257-261, 2016 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26707399
7.
Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.
Bioorg Med Chem Lett
; 25(16): 3157-63, 2015 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26099534
8.
Convergent synthesis of thiodiazole dioxides from simple ketones and amines through an unusual nitrogen-migration mechanism.
Chem Sci
; 15(1): 328-335, 2023 Dec 20.
Artigo
Inglês
| MEDLINE | ID: mdl-38131085
9.
Reply to "A Comment on 'Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8'".
J Pharmacol Exp Ther
; 358(3): 527, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27528545
10.
Development of a flexible strategy towards FR900482 and the mitomycins.
Chemistry
; 17(28): 7890-903, 2011 Jul 04.
Artigo
Inglês
| MEDLINE | ID: mdl-21618622
11.
Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors.
Bioorg Med Chem Lett
; 20(14): 4060-4, 2010 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20541404
12.
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.
Bioorg Med Chem Lett
; 20(7): 2370-4, 2010 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20153648
13.
Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.
Eur J Pharmacol
; 880: 173171, 2020 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32437743
14.
Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency.
Bioorg Med Chem Lett
; 19(21): 6135-9, 2009 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19783435
15.
Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
Bioorg Med Chem Lett
; 19(21): 6131-4, 2009 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19773165
16.
Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators.
ACS Med Chem Lett
; 10(3): 267-272, 2019 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-30891124
17.
Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8.
ACS Med Chem Lett
; 9(8): 821-826, 2018 Aug 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30128074
18.
A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334.
Eur J Pharmacol
; 765: 551-9, 2015 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26386289
19.
Pd-catalyzed carbonylative lactamization: a novel synthetic approach to FR900482.
Org Lett
; 6(11): 1745-8, 2004 May 27.
Artigo
Inglês
| MEDLINE | ID: mdl-15151404
20.
Phosphoinositide 3-kinase gamma (PI3Kgamma) inhibitors for the treatment of inflammation and autoimmune disease.
Recent Pat Inflamm Allergy Drug Discov
; 4(1): 1-15, 2010 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-20017720