Detalhe da pesquisa
1.
Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics.
Nucleic Acids Res
; 50(13): 7545-7559, 2022 07 22.
Artigo
Inglês
| MEDLINE | ID: mdl-35801923
2.
Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
J Am Chem Soc
; 139(9): 3528-3536, 2017 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28230359
3.
Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations.
J Biol Chem
; 287(17): 13598-610, 2012 Apr 20.
Artigo
Inglês
| MEDLINE | ID: mdl-22298776
4.
Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine.
Sci Transl Med
; 15(693): eade6422, 2023 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37023209
5.
Structural basis of the acyl-transfer mechanism of human GPAT1.
Nat Struct Mol Biol
; 30(1): 22-30, 2023 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36522428
6.
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.
Nat Struct Mol Biol
; 14(5): 413-9, 2007 May.
Artigo
Inglês
| MEDLINE | ID: mdl-17435765
7.
Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.
Nat Struct Mol Biol
; 14(2): 106-13, 2007 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-17237796
8.
Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20.
Nat Commun
; 11(1): 3031, 2020 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32541785
9.
Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun
; 11(1): 1598, 2020 03 27.
Artigo
Inglês
| MEDLINE | ID: mdl-32221310
10.
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
Bioorg Med Chem Lett
; 19(7): 1991-5, 2009 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19275964
11.
2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety.
J Med Chem
; 61(7): 3114-3125, 2018 04 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29570292
12.
The 2.0 A crystal structure of the ERalpha ligand-binding domain complexed with lasofoxifene.
Protein Sci
; 16(5): 897-905, 2007 May.
Artigo
Inglês
| MEDLINE | ID: mdl-17456742
13.
cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization.
J Med Chem
; 49(11): 3068-76, 2006 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16722626
14.
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment.
ACS Med Chem Lett
; 6(11): 1128-33, 2015 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-26617966
15.
Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.
Chem Biol
; 21(2): 284-94, 2014 Feb 20.
Artigo
Inglês
| MEDLINE | ID: mdl-24440079
16.
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
J Med Chem
; 55(3): 1318-33, 2012 Feb 09.
Artigo
Inglês
| MEDLINE | ID: mdl-22196621
17.
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.
Bioorg Med Chem Lett
; 17(20): 5638-42, 2007 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17822893
18.
Specificity determinants of human cathepsin s revealed by crystal structures of complexes.
Biochemistry
; 42(11): 3203-13, 2003 Mar 25.
Artigo
Inglês
| MEDLINE | ID: mdl-12641451
19.
Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics.
Bioorg Med Chem Lett
; 13(3): 379-82, 2003 Feb 10.
Artigo
Inglês
| MEDLINE | ID: mdl-12565933