Detalhe da pesquisa
1.
A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.
Kidney Int
; 100(2): 311-320, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33836171
2.
Structure guided development of potent piperazine-derived hydroxamic acid inhibitors targeting falcilysin.
Bioorg Med Chem Lett
; 32: 127683, 2021 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33227414
3.
Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A.
FASEB J
; 33(10): 11247-11257, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31299174
4.
Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis.
PLoS Pathog
; 12(5): e1005628, 2016 May.
Artigo
Inglês
| MEDLINE | ID: mdl-27191388
5.
Aquaporin-Targeted Therapeutics: State-of-the-Field.
Adv Exp Med Biol
; 969: 239-250, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28258578
6.
Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1.
Mol Pharmacol
; 89(6): 686-93, 2016 06.
Artigo
Inglês
| MEDLINE | ID: mdl-26993802
7.
Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters.
Biochim Biophys Acta
; 1848(5): 1075-80, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-25613743
8.
Identification of non-covalent SARS-CoV-2 main protease inhibitors by a virtual screen of commercially available drug-like compounds.
Bioorg Med Chem Lett
; 41: 127990, 2021 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33775840
9.
Corrigendum to "Structure guided development of potent piperazine-derived hydroxamic acid inhibitors targeting falcilysin" [Bioorg. Med. Chem. Lett. 32 (2021) 127683].
Bioorg Med Chem Lett
; 37: 127836, 2021 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33588181
10.
Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.
J Enzyme Inhib Med Chem
; 31(6): 1362-8, 2016 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26796863
11.
Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP.
Mol Pharmacol
; 88(4): 689-96, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26174774
12.
Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.
Kidney Int
; 88(2): 311-20, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-25993324
13.
Global identification of peptidase specificity by multiplex substrate profiling.
Nat Methods
; 9(11): 1095-100, 2012 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23023596
14.
X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis.
PLoS Pathog
; 9(8): e1003576, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23990788
15.
Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.
FASEB J
; 28(9): 3878-90, 2014 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-24843071
16.
Small-molecule inhibitors of urea transporters.
Subcell Biochem
; 73: 165-77, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25298345
17.
Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria.
RSC Med Chem
; 15(5): 1731-1736, 2024 May 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38784456
18.
A small-molecule screen yields idiotype-specific blockers of neuromyelitis optica immunoglobulin G binding to aquaporin-4.
J Biol Chem
; 287(44): 36837-44, 2012 Oct 26.
Artigo
Inglês
| MEDLINE | ID: mdl-22989877
19.
Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica.
FASEB J
; 26(5): 2197-208, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22319008
20.
Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration.
J Am Soc Nephrol
; 23(7): 1210-20, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22491419