Detalhe da pesquisa
1.
Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles.
Bioorg Med Chem Lett
; 37: 127843, 2021 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33556576
2.
Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi Y strain (DTU TcII): in vitro and in vivo studies.
Parasitology
; 147(11): 1216-1228, 2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32530391
3.
In vitro assessment of 3-alkoxy-5-nitroindazole-derived ethylamines and related compounds as potential antileishmanial drugs.
Bioorg Chem
; 92: 103274, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31539744
4.
Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi.
Parasitol Res
; 117(11): 3367-3380, 2018 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-30232605
5.
Simple dialkyl pyrazole-3,5-dicarboxylates show in vitro and in vivo activity against disease-causing trypanosomatids.
Parasitology
; 144(9): 1133-1143, 2017 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-28367781
6.
In vitro trichomonacidal activity and preliminary in silico chemometric studies of 5-nitroindazolin-3-one and 3-alkoxy-5-nitroindazole derivatives.
Parasitology
; 143(1): 34-40, 2016 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-26525913
7.
Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes.
Parasitology
; 143(11): 1469-78, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27312370
8.
A new type of quinoxalinone derivatives affects viability, invasion, and intracellular growth of Toxoplasma gondii tachyzoites in vitro.
Parasitol Res
; 115(5): 2081-96, 2016 May.
Artigo
Inglês
| MEDLINE | ID: mdl-26888289
9.
Novel solid dispersions of benznidazole: preparation, dissolution profile and biological evaluation as alternative antichagasic drug delivery system.
Exp Parasitol
; 149: 84-91, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25583295
10.
Antiprotozoan lead discovery by aligning dry and wet screening: prediction, synthesis, and biological assay of novel quinoxalinones.
Bioorg Med Chem
; 22(5): 1568-85, 2014 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24513185
11.
Further insights into biological evaluation of new anti-Trypanosoma cruzi 5-nitroindazoles.
Parasitol Res
; 113(3): 1049-56, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24435615
12.
In vivo genotoxicity and cytotoxicity assessment of a novel quinoxalinone with trichomonacide activity.
J Appl Toxicol
; 33(12): 1493-9, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-23047729
13.
Biological assay of a novel quinoxalinone with antimalarial efficacy on Plasmodium yoelii yoelii.
Parasitol Res
; 112(4): 1523-7, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23338979
14.
Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies.
Bioorg Med Chem Lett
; 22(14): 4506-16, 2012 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22738640
15.
Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants.
Parasitol Res
; 110(4): 1381-92, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21922239
16.
5-Nitroindazole derivatives as potential therapeutic alternatives against Acanthamoeba castellanii.
Acta Trop
; 232: 106538, 2022 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-35618027
17.
5-Nitroindazole-based compounds: further studies for activity optimization as anti-Trypanosoma cruzi agents.
Acta Trop
; 234: 106607, 2022 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-35907502
18.
Hydrogen-bond-mediated self-assembly of 26-membered diaza tetraester crowns of 3,5-disubstituted 1H-pyrazole. Dimerization study in the solid state and in CDCl3 solution.
J Org Chem
; 76(20): 8223-31, 2011 Oct 21.
Artigo
Inglês
| MEDLINE | ID: mdl-21910468
19.
X-ray diffraction, solution structure, and computational studies on derivatives of (3-sec-butyl-2,3-dihydro-1H-isoquinolin-4-ylidene)acetic acid: compounds with activity as calpain inhibitors.
J Org Chem
; 75(2): 342-52, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20014819
20.
Selective electrochemical discrimination between dopamine and phenethylamine-derived psychotropic drugs using electrodes modified with an acyclic receptor containing two terminal 3-alkoxy-5-nitroindazole rings.
Analyst
; 135(6): 1449-55, 2010 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-20407681