RESUMO
A distinct cluster of highly pathogenic avian influenzaviruses of subtype A(H5N1) has been found to emergewithin clade 2.2.1.2 in poultry in Egypt since summer2014 and appears to have quickly become predominant.Viruses of this cluster may be associated withincreased incidence of human influenza A(H5N1) infectionsin Egypt over the last months.
Assuntos
Virus da Influenza A Subtipo H5N1/genética , Influenza Aviária/virologia , Influenza Humana/virologia , Aves Domésticas , Animais , Doenças Transmissíveis Emergentes , Egito/epidemiologia , Glicoproteínas de Hemaglutininação de Vírus da Influenza/genética , Humanos , Virus da Influenza A Subtipo H5N1/isolamento & purificação , Influenza Aviária/diagnóstico , Influenza Humana/epidemiologia , Filogenia , Aves Domésticas/virologia , Doenças das Aves Domésticas/epidemiologia , RNA Viral/genética , Análise de Sequência de RNARESUMO
Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are enzootic in poultry populations in different parts of the world, and have caused numerous human infections in recent years, particularly in Egypt. However, no sustained human-to-human transmission of these viruses has yet been reported. We tested nine naturally occurring Egyptian H5N1 viruses (isolated in 2014-2015) in ferrets and found that three of them transmitted via respiratory droplets, causing a fatal infection in one of the exposed animals. All isolates were sensitive to neuraminidase inhibitors. However, these viruses were not transmitted via respiratory droplets in three additional transmission experiments in ferrets. Currently, we do not know if the efficiency of transmission is very low or if subtle differences in experimental parameters contributed to these inconsistent results. Nonetheless, our findings heighten concern regarding the pandemic potential of recent Egyptian H5N1 influenza viruses.
Assuntos
Virus da Influenza A Subtipo H5N1/genética , Infecções por Orthomyxoviridae/epidemiologia , Infecções por Orthomyxoviridae/veterinária , Animais , Antivirais/farmacologia , Bioensaio , Cães , Egito/epidemiologia , Inibidores Enzimáticos/farmacologia , Furões , Expressão Gênica , Células HeLa , Humanos , Virus da Influenza A Subtipo H5N1/classificação , Virus da Influenza A Subtipo H5N1/efeitos dos fármacos , Virus da Influenza A Subtipo H5N1/isolamento & purificação , Células Madin Darby de Rim Canino , Neuraminidase/antagonistas & inibidores , Neuraminidase/genética , Neuraminidase/metabolismo , Infecções por Orthomyxoviridae/tratamento farmacológico , Infecções por Orthomyxoviridae/transmissão , Filogenia , Medição de Risco , Carga Viral/efeitos dos fármacos , Proteínas Virais/antagonistas & inibidores , Proteínas Virais/genética , Proteínas Virais/metabolismoRESUMO
An experiment was conducted with Hy-Line W36 hens to determine the influence of age on tibia ash and breaking strength of hens kept in cages and floor pens. Breaking strength progressively decreased from 20 to 32 weeks of age for hens kept in cages and floor pens. However, the decrease was greater with hens kept in cages. Tibia ash progressively increased from 20 to 32 weeks of age; there was no difference after 23 weeks of age between cage and floor groups. Twenty hens were moved from cages to floor and 20 were moved from the floor to cages at 26 weeks of age. Tibia breaking strength did not significantly change for those moved from cages to floor and decreased for those moved from floor to cages. The difference between the two groups was not statistically significant at 32 weeks of age.
Assuntos
Envelhecimento , Osso e Ossos/fisiologia , Galinhas/fisiologia , Animais , Feminino , Resistência à Tração , Tíbia/fisiologiaRESUMO
Two experiments were conducted to determine the influence of Protamone on fatty liver syndrome in commercial laying hens. The addition of either 110 or 220 mg of protamone per kilogram of diet significantly lowered liver fat and also significantly reduced body weight. From histological examination of livers of hens fed Protamone it was found that the hepatocytes contained little or no lipid, whereas hepatocytes of hens fed the control diet were turgid with lipid. The addition of Protamone to the diet resulted in a significant reduction in egg production without effecting feed efficiency in Experiment 1. In Experiment 2, egg production was significantly reduced and feed efficiency improved during Days 1 to 28. However, feed efficiency was poorer during Days 29 to 56 for hens receiving the Protamone.
Assuntos
Caseínas/uso terapêutico , Galinhas , Fígado Gorduroso/veterinária , Iodoproteínas/uso terapêutico , Doenças das Aves Domésticas/dietoterapia , Animais , Caseínas/administração & dosagem , Fígado Gorduroso/dietoterapia , Fígado Gorduroso/patologia , Feminino , Aditivos Alimentares/administração & dosagem , Iodoproteínas/administração & dosagem , Fígado/patologia , Doenças das Aves Domésticas/patologia , Síndrome/veterinária , Glândula Tireoide/efeitos dos fármacosRESUMO
Two experiments were conducted each consisting of two trials. Day-old Bobwhite quail were fed a starter diet containing a microbial preparation of Lactobacilli. In both experiments the experimental diets were fed for 5 weeks. No significant differences in growth, feed efficiency, or mortality were found between the control and Lactobacilli supplemented diets. Mortality was higher than normal within all treatments but unaffected by treatment.
Assuntos
Ração Animal , Lactobacillus , Codorniz/fisiologia , Animais , Doenças das Aves/mortalidade , Peso Corporal , Distúrbios Nutricionais/mortalidade , Distúrbios Nutricionais/veterináriaAssuntos
Anopheles/efeitos dos fármacos , Resistência a Inseticidas , DDT , Egito , Métodos Epidemiológicos , Humanos , Insetos Vetores , MaláriaRESUMO
Two Saudi patients who underwent cardiac surgery, developed fever after being discharged from hospital. Both received blood transfusion during operation. The cause of fever was found to be due to malaria acquired from the transfused blood. As no single measure could prevent transfusion malaria, clinical awareness of the condition should lead to early diagnosis and management of such cases.
Assuntos
Procedimentos Cirúrgicos Cardíacos , Malária Falciparum/transmissão , Malária Vivax/transmissão , Complicações Pós-Operatórias , Reação Transfusional , Adulto , Feminino , Humanos , Lactente , Malária Falciparum/diagnóstico , Malária Falciparum/etiologia , Malária Vivax/diagnóstico , Malária Vivax/etiologia , Masculino , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/etiologia , Arábia SauditaRESUMO
1. The relative sensitivities of broiler chicks, White Leghorn chicks, quail chicks, goslings and turkey poults to increasing dietary contents of aflatoxin from 1 to 21 d of age were determined. Aflatoxin was included in the diets at three concentrations (0.7, 1.4 and 2.1 mg aflatoxin B1 equivalents/kg). 2. Data were analysed for species differences in food consumption, body weight, food utilisation, mortality and liver pathology. 3. There were no significant effects of aflatoxin in broiler and Leghorn chicks. Aflatoxin at 0.7 mg/kg decreased the body weight of turkey poults but tended to increase the growth rate of goslings. At 1.4 mg aflatoxin/kg food consumption, body weight and weight gain of goslings were adversely affected. 4. Liver damage occurred in goslings and quail chicks at all inclusions of aflatoxin and was extensive at 2.1 mg/kg. 5. Poults and goslings appeared to be the most sensitive, quail were intermediate and domestic chicks were most resistant.