RESUMO
INTRODUCTION: The purpose of our study is to describe 4 cases of sexsomnia, a form of parasomnia characterised by sexual behaviour during sleep. METHODS: Clinical history and video-polysomnography recordings from patients diagnosed with sexsomnia in the Multidisciplinary Sleep Unit at Hospital Clínic in Barcelona. RESULTS: Three men and one woman between 28 and 43 years of age reported sexual behaviours during sleep with progression times ranging from 9 months to 7 years. Episodes consisted of masturbation without seeking the participation of a sleeping partner (2 cases) and attempts at sexual intercourse with inappropriate and uncharacteristic vocalizations and behaviours (3 cases). The frequency of the episodes ranged from 4 isolated episodes to 2-3 per week. Patients were amnestic of these events and surprised by their partners' accounts of their behaviour. Medical histories revealed that 1 patient was a somnambulist, 2 had confusional arousals, and 1 experienced somniloquy. Video-polysomnography did not disclose sexual behaviours during sleep but revealed sleep apnoea in 2 cases and periodic leg movements in sleep in another. The only patient treated with clonazepam reported decreased frequency of both confusional arousals and sexsomnia episodes. CONCLUSIONS: Sexsomnia occurs in young adults and is characterised by masturbation and inappropriate attempts at achieving sexual intercourse followed by total amnesia of the events. It can be associated with other parasomnias such as sleepwalking and confusional arousals. Other sleep disorders, including sleep apnoea and periodic leg movement disorder, may trigger episodes of sexsomnia.
Assuntos
Parassonias/psicologia , Comportamento Sexual/psicologia , Transtornos do Sono-Vigília/psicologia , Adulto , Feminino , Humanos , Masculino , PolissonografiaAssuntos
Anticorpos Antinucleares/sangue , Anticorpos Antifosfolipídeos/sangue , Aquaporina 4/imunologia , Lúpus Eritematoso Sistêmico/sangue , Mielite Transversa/diagnóstico , Adulto , Feminino , Humanos , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Imageamento por Ressonância Magnética , Mielite Transversa/etiologiaRESUMO
Autoimmune encephalitis are a new category of inflammatory diseases of the central nervous system mediated by antibodies that attack neurotransmitter or protein receptors on the surface of neurons. The clinical syndromes are complex and are associated with manifestations that vary according to the type of antibody that is associated. The autoimmune response can start due to the presence of a tumour or viral infection, but in many case the cause remains unknown. In paediatrics, the most frequent autoimmune encephalitis is that associated with NMDA glutamate receptor antibodies (or anti-NMDA encephalitis). In children and teenagers, the initial symptoms are usually different from those of adults and the disease is rarely associated with tumours. In this article, in addition to anti-NMDA encephalitis, the general aspects of autoimmune encephalitis are reviewed and the most common questions asked about treatment of these diseases are addressed.
TITLE: Encefalitis autoinmunes.Las encefalitis autoinmunes constituyen una nueva categoria de enfermedades inflamatorias del sistema nervioso central mediadas por anticuerpos contra receptores de neurotransmisores o proteinas de la superficie neuronal. Los sindromes clinicos son complejos y se asocian a manifestaciones que varian en funcion del tipo de anticuerpo asociado. La respuesta autoinmune puede iniciarse por la presencia de un tumor o infeccion virica, pero en muchos casos se desconoce la causa. En pediatria, la encefalitis autoinmune mas frecuente es la que se asocia a anticuerpos contra el receptor de glutamato NMDA (o encefalitis anti-NMDAR). En niños y adolescentes, los sintomas iniciales suelen ser diferentes a los de los adultos y la enfermedad raramente se asocia a tumores. En este articulo, ademas de la encefalitis anti-NMDAR, se revisan los aspectos generales de las encefalitis autoinmunes y se abordan las preguntas mas frecuentes que suscita el tratamiento de estas enfermedades.
Assuntos
Encefalite , Doença de Hashimoto , Encefalite/diagnóstico , Encefalite/imunologia , Encefalite/terapia , Doença de Hashimoto/diagnóstico , Doença de Hashimoto/imunologia , Doença de Hashimoto/terapia , HumanosRESUMO
Simple decompression of the ulnar nerve at the elbow has not been shown to reduce nerve strain in cadavers. In this study, ulnar nerve strain at the elbow was measured intraoperatively in 11 patients with cubital tunnel syndrome, before and after simple decompression. Statistical analysis was performed using a paired Student's t-test. Mean ulnar nerve strain before and after simple decompression was 30.5% (range 9% to 69%) and 5.5% (range -2% to 11%), respectively; this difference was statistically significant (p < 0.01) with a statistical power of 96%. Simple decompression reduced ulnar nerve strain in all patients by an average of 24.5%. Our results suggest that the pathophysiology of cubital tunnel syndrome may be multifactorial, being neither a simple compression neuropathy nor a simple traction neuropathy, and simple decompression may be a favourable surgical procedure for cubital tunnel syndrome in terms of decompression and reduction of strain in the ulnar nerve.
Assuntos
Síndrome do Túnel Ulnar/cirurgia , Nervo Ulnar/cirurgia , Adulto , Idoso , Síndrome do Túnel Ulnar/diagnóstico , Síndrome do Túnel Ulnar/fisiopatologia , Descompressão Cirúrgica , Eletrodiagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Condução Nervosa/fisiologia , Resultado do Tratamento , Nervo Ulnar/fisiopatologiaRESUMO
Introducción: El objetivo de nuestro trabajo es describir 4 casos de sexsomnia, una parasomnia caracterizada por conductas sexuales durante el sueño. Método: Historia clínica y registro videopolisomnográfico de pacientes identificados en la unidad multidisciplinaria del sueño del Hospital Clínic de Barcelona. Resultados: Tres varones y una mujer entre 28 y 43 años de edad referían conductas sexuales durante el sueño de entre 9 meses y 7 años de evolución. Consistían en la masturbación sin buscar la participación de la pareja, que dormía en la misma cama (2 casos), e intentar el coito con vigorosidad conductual y verbal inapropiada e inhabitual (3 casos). La frecuencia era variable entre 4 únicos episodios y 2-3 semanales. Los pacientes presentaban amnesia completa de los eventos y sorpresa cuando se les explicaba lo que habían hecho. Había antecedentes de sonambulismo (un caso), despertares confusos (2 casos) y somniloquia (un caso). Los registros polisomnográficos con vídeo no detectaron conductas sexuales pero registraron apneas (2 casos) y movimientos periódicos de las piernas (un caso). En el único paciente en que se probó clonacepam la frecuencia de la sexsomnia y los despertares confusos disminuyó. Conclusión: La sexsomnia aparece en el adulto joven, consiste en intentar consumar de forma inapropiada el coito o masturbarse durante el sueño, con amnesia posterior de lo ocurrido. Puede coexistir con otras parasomnias, como sonambulismo y despertares confusos. Otros trastornos del sueño, como las apneas y los movimientos periódicos de las piernas, podrían desencadenar los episodios de sexsomnia
Introduction: The purpose of our study is to describe 4 cases of sexsomnia, a form of parasomnia characterised by sexual behaviour during sleep. Methods: Clinical history and video-polysomnography recordings from patients diagnosed with sexsomnia in the Multidisciplinary Sleep Unit at Hospital Clínic in Barcelona. Results: Three men and one woman between 28 and 43 years of age reported sexual behaviours during sleep with progression times ranging from 9 months to 7 years. Episodes consisted of masturbation without seeking the participation of a sleeping partner (2 cases) and attempts at sexual intercourse with inappropriate and uncharacteristic vocalisations and behaviours (3 cases). The frequency of the episodes ranged from 4 isolated episodes to 2-3 per week. Patients were amnestic of these events and surprised by their partners accounts of their behaviour. Medical histories revealed that 1 patient was a somnambulist, 2 had confusional arousals, and 1 experienced somniloquy. Video-polysomnography did not disclose sexual behaviours during sleep but revealed sleep apnoea in 2 cases and periodic leg movements in sleep in another. The only patient treated with clonazepam reported decreased frequency of both confusional arousals and sexsomnia episodes. Conclusions: Sexsomnia occurs in young adults and is characterised by masturbation and inappropriate attempts at achieving sexual intercourse followed by total amnesia of the events. It can be associated with other parasomnias such as sleepwalking and confusional arousals. Other sleep disorders, including sleep apnoea and periodic leg movement disorder, may trigger episodes of sexsomnia
Assuntos
Humanos , Masculino , Feminino , Adulto , Comportamento Sexual/psicologia , Transtornos do Sono-Vigília/diagnóstico , Transtorno do Comportamento do Sono REM/diagnóstico , Parassonias/diagnóstico , Polissonografia , Confusão/etiologiaRESUMO
Most injuries to the femoral nerve are iatrogenic in origin and occur during resection of large retroperitoneal tumours. When the defect is considerable a nerve graft is mandatory to avoid tension across the suture line. We describe two cases of iatrogenic femoral nerve injury which recovered well after reconstruction with long sural nerve grafts. The probable reasons for success were that we performed the grafting soon after the injury, the patients were not too old, the nerve repairs were reinforced with fibrin glue and electrical stimulation of the quadriceps was administered to prevent muscle atrophy. Good functional results may be obtained if these conditions are satisfied even if the length of a nerve graft is more than 10 cm.
Assuntos
Nervo Femoral/transplante , Complicações Intraoperatórias/cirurgia , Transferência de Nervo/métodos , Neurilemoma/cirurgia , Neoplasias Retroperitoneais/cirurgia , Nervo Sural/transplante , Adulto , Nervo Femoral/fisiopatologia , Humanos , Complicações Intraoperatórias/etiologia , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Transferência de Nervo/normas , Recuperação de Função Fisiológica/fisiologia , Nervo Sural/fisiopatologiaRESUMO
Transfer of the abductor pollicis longus tendon to restore index abduction was performed simultaneously with ulnar nerve decompression in severe cases of cubital tunnel syndrome. Eighteen elbows in 18 patients were evaluated with an average follow-up period of 46 (range 12-120) months. The status of the ulnar nerve palsy was evaluated by the Yasutake's scoring method. The mean score improved from 48 points pre-operatively to 78 points at final follow-up (maximum score 100 points). Pinch strength improved from 39% of the opposite side pre-operatively to 81% finally and it reached a plateau one year postoperatively. Despite this improvement in pinch strength, atrophy of the interosseous muscle did not disappear in nine of 12 patients with a follow-up of more than two years. All patients were satisfied with the results of increased strength and stability in pinching ability. No complications occurred.
Assuntos
Síndrome do Túnel Ulnar/cirurgia , Transferência Tendinosa , Idoso , Atrofia , Síndrome do Túnel Ulnar/fisiopatologia , Feminino , Força da Mão , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/patologia , Transferência Tendinosa/métodosRESUMO
We have performed minimal medial epicondylectomy for cubital tunnel syndrome since 1990 to preserve the anterior medial collateral ligament. In this study we compared surgical outcomes between partial medial epicondylectomy (14 patients) and minimal medial epicondylectomy (18 patients) combined with ulnar nerve decompression for the treatment of cubital tunnel syndrome. Mean preoperative Yasutake scores were 57 +/- 17 points (+/-SD) in the partial epicondylectomy group and 60 +/- 15 points in the minimal medial epicondylectomy group. The postoperative scores were 79 +/- 19 points and 87 +/- 10 points, respectively. Both groups had significant improvement in their Yasutake scores following medial epicondylectomy. Similar improvements in motor conduction velocity were observed. There was no significant difference in improvement of either the Yasutake scores or the motor conduction velocity between the 2 groups. Valgus instability of the elbow was significantly greater in the partial epicondylectomy group. We therefore conclude that minimal medial epicondylectomy combined with ulnar nerve decompression is an effective treatment for cubital tunnel syndrome and that a larger excision of the medial epicondyle should be avoided.
Assuntos
Síndrome do Túnel Ulnar/cirurgia , Descompressão Cirúrgica/métodos , Úmero/cirurgia , Adulto , Idoso , Doença Crônica , Síndrome do Túnel Ulnar/diagnóstico por imagem , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Radiografia , Resultado do TratamentoRESUMO
An experimental study was performed to investigate the influence of chronic inflammation in peripheral target tissue on recovery of the sciatic nerve after crush injury. Thirty-four male Wistar rats, weighing 300-370 g were used. The sciatic nerve was crushed unilaterally with an aneurysm clip (250 gf; holding force; 5 min). One week before the operation, chronic inflammation, localized in the tibiotarsal joint of one hind limb, was produced by the intraarticular injection of complete Freund's adjuvant. The animals were divided into five groups, as follows: CIA (crush injury with ipsilateral arthritis), CCA (crush injury with contralateral arthritis), C (crush injury without arthritis), A (sham operation and ipsilateral arthritis), and S (sham operation without arthritis). Specimens for histological examination were taken from the nerve at a site 5 mm distal to the crush injury 4 weeks postoperatively. Histological study showed that the diameters of the axons in group CIA were significantly smaller than those in group CCA and those in group C. No significant differences were observed between group CCA and group C. In conclusion, peripheral nerve recovery after crush injury was suppressed by chronic inflammation in peripheral target tissue.
Assuntos
Nervos Periféricos/patologia , Animais , Artrite/patologia , Axônios/patologia , Doença Crônica , Inflamação/patologia , Masculino , Traumatismos dos Nervos Periféricos , Ratos , Ratos WistarRESUMO
The authors report a newly devised nerve stimulator and its clinical application in thoracoscopic surgery. The stimulator is a monopolar system, that has a long extension between the electrodes and the handle. The stimulator is inserted into the chest cavity through a portal, and is used to distinguish motor nerves from the surrounding tissue and to determine whether there is nerve involvement with tumor. The tumor is then safely and rapidly resected by thoracoscopic technique and the major nerves are spared. This method was used in two clinical cases, with excellent results obtained, and with no major complications.