RESUMO
Whole blood filterability was measured in 53 stroke patients (28 patients 40-60 yr and 25 patients greater than 60 yr) to study the hemorheologic parameters, stressing the changes occurring in the elderly. A negative linear correlation was found between whole blood filterability and the hematocrit, plasma viscosity and the serum level of macroproteins (alpha 2-globulin, gamma-globulin and fibrinogen), indicating that whole blood filterability is a collective measure of the different hemorheologic parameters. Whole blood filterability was significantly reduced in stroke patients as compared to normal control values. This reduction could not be attributed to a difference in hematocrit or plasma viscosity, which emphasizes the role of red cell deformability in the filterability of blood of stroke patients. Moreover, whole blood filterability was significantly lower in stroke patients more than 60 yr old than in stroke patients less than 60 yr old. Both plasmatic and red cell factors were contributing factors in the reduction of filterability in the elderly.
Assuntos
Envelhecimento/fisiologia , Circulação Cerebrovascular , Transtornos Cerebrovasculares/fisiopatologia , Hemodinâmica , Adulto , Idoso , Envelhecimento/sangue , Proteínas Sanguíneas/análise , Viscosidade Sanguínea , Transtornos Cerebrovasculares/sangue , Transtornos Cerebrovasculares/etiologia , Deformação Eritrocítica , Feminino , Filtração , Hematócrito , Humanos , Masculino , Microcirculação , Pessoa de Meia-IdadeRESUMO
In this work, the serum immunoglobulin (IgG, IgA, IgM and IgD) levels were determined in ten patients with chronic tonsillitis. The serum immunoglobulins were estimated before and two months after tonsillectomy, using the radial immuno-diffusion method. Ten normal individuals with intact tonsils were chosen as a control group. The patients had elevated serum levels of IgG and IgA. These high levels may be due to repeated antigenic stimulation. The IgM and IgD were not significantly higher than in the normal controls. The serum IgG level did decrease significantly following tonsillectomy; the other three immunoglobulins were reduced, but insignificantly. The fall in immunoglobulins may be due to a reduction in the antigenic load, to the removal of immunoglobulin-producing tissue, or to alteration in the oropharyngeal pathogenic bacteria. Tonsillectomy does not seem to compromise immunological integrity or the immunoglobulin-producting apparatus. Estimations of the serum immunoglobulin, or simply of IgA, may help us to select those candidates for adeno-tonsillectomy who will have a good prognosis, or at least to exclude those with an underlying sub-clinical immunodeficiency disease.
Assuntos
Imunoglobulinas/análise , Tonsilite/imunologia , Adolescente , Criança , Pré-Escolar , Doença Crônica , Feminino , Humanos , Imunoglobulina A/análise , Imunoglobulina D/análise , Imunoglobulina G/análise , Imunoglobulina M/análise , Masculino , Tonsilectomia , Tonsilite/cirurgiaRESUMO
PIP: To determine the effect of a long-acting injectable progestogen-estrogen contraceptive (Deladroxate) on blood coagulation and fibrinolysis, 67 multiparous women receiving the contraceptive for 12 to 14 cycles aged 18-40 years were followed-up monthly for 1 year. The prothrombin consumption index, prothrombin percentage, whole blood clotting time, plasma fibrinogen, clot retraction, bleeding time, and fibrinolytic activity of all patients were all within normal limits both 6 and 12 months after beginning of treatment. Research on the relationship of contraceptive use and occurrence of thrombophlebitis is contradictory and no valid test for measuring blood coagulability exists that is satisfactory for these investigations. This study concludes nevertheless that no aberrations in blood coagulation occurred from this progestogen-estrogen treatment.^ieng
Assuntos
Acetofenida de Algestona , Coagulação Sanguínea , Sangue , Etinilestradiol , Fibrinólise , Pesquisa , Biologia , Anticoncepção , Anticoncepcionais , Anticoncepcionais Femininos , Anticoncepcionais Orais Hormonais , Serviços de Planejamento Familiar , FisiologiaRESUMO
Forty-four patients with schistosomiasis mansoni were divided into two groups: a group of 31 patients with hepatosplenomegaly and a group of 13 patients with advanced hepatic fibrosis and ascites. Both groups were compared to a control group of 14 healthy subjects. Screening of the extrinsic and intrinsic coagulation pathways was performed by PT (%) and aPTT. Functional assays of vitamin-K-dependent coagulation proteins: factors II, VII, IX, X, and protein C were conducted by using standard methods. A progressive reduction in PT (%) and prolongation in aPTT were detected in the diseased groups. Furthermore, all studied coagulation proteins showed a progressive reduction in their activities, which became more pronounced in the group with advanced ascites. We conclude that the significant reduction in vitamin-K-dependent coagulation proteins might add to the coagulopathy and bleeding diathesis noted in patients infected with Schistosoma mansoni.
Assuntos
Fatores de Coagulação Sanguínea/análise , Transtornos Hemorrágicos/etiologia , Esquistossomose mansoni/sangue , Adolescente , Adulto , Ascite/sangue , Ascite/etiologia , Criança , Fator IX/análise , Fator VII/análise , Fator X/análise , Hepatomegalia/sangue , Hepatomegalia/etiologia , Humanos , Cirrose Hepática/sangue , Cirrose Hepática/etiologia , Pessoa de Meia-Idade , Tempo de Tromboplastina Parcial , Proteína C/análise , Protrombina/análise , Tempo de Protrombina , Esquistossomose mansoni/complicações , Esplenomegalia/sangue , Esplenomegalia/etiologiaRESUMO
Forty-three previously untreated Egyptian patients with Hodgkin's disease and thirty-five patients with non-Hodgkin lymphoma were studied with several readily available tests of immune function, number of peripheral blood lymphocytes, delayed hypersensitivity to two recall antigens, in vitro blastoid transformation by PHA, the capacity of E-rosette formation and surface marker criteria. The results were correlated to the histology, stage of disease and to the presence of general symptoms and signs.