Low cognitive competence as a vulnerability factor for behavioral despair in rats.

Elucidating the multi-faceted relationship between cognitive competence and affective states is a major pursuit in behavioral sciences. Mood disorders constitute a good research model for this question, as cognitive impairment may accompany clinical depression and persist after full remission. This suggests cognitive dysfunction as an etiological factor of depression, rather than an epiphenomenon. Complementing clinical studies, animal models utilizing well-controlled, systematic paradigms are essential to elucidate the complex relationship between cognitive competence and affective states. In current set of experiments, we investigated the extent to which cognitive competence determines the stress response in Wistar rats by utilizing two well-established spatial memory paradigms with different degrees of complexity together with the forced swim test. We revealed that rats with low cognitive competence as assessed by learning performance in the Y-Maze, but not in the radial arm maze, were significantly more vulnerable to behavioral despair. In contrast, rats with high cognitive competence were resilient to the negative effects of the forced swim test, irrespective of the spatial memory task used. These results point to a nonlinear relationship between spatial memory performance and behavioral despair, suggesting that different types of cognitive functioning may have differential effects on affective processes.

Multilevel Impact of Prenatal Risk and Protective Factors on Stress Biology and Infant Development: Study protocol of BABIP prospective birth cohort from Turkey.

Prenatal environment has long-lasting effects on offspring development and health. Research on prenatal stress identified various mechanisms of these effects, from changes in epigenetic and gene expression profiles to Maternal-Placental-Fetal (MPF) stress biology. There is also evidence for the role of additional risk and protective factors influencing the impact of prenatal stress on maternal and infant outcomes. Considering these findings, we present the study protocol of BABIP, a prospective birth cohort from Turkey. The aim of the project is to investigate the effect of prenatal stress on MPF stress biology (i.e. neuroendocrine, immune and metabolic systems), differential DNA methylation and gene expression patterns, and infant birth and developmental outcomes. We are recruiting 150 pregnant women and their babies for a longitudinal project with 4 time points: 20-24 (T1) and 30-34 (T2) weeks of pregnancy, and 1-month (T3) and 4-months (T4) after giving birth. Maternal early and prenatal environment (prenatal stress, early life stress, psychosocial resources, and health-related behaviors) are assessed during pregnancy with MPF stress biology, DNA methylation and gene expression measures. Infant birth outcomes, DNA methylation and development are assessed postpartum. BABIP is the first prospective birth cohort from Turkey with extensive measures on prenatal environment and health. Through investigating the multilevel impact of prenatal stress and related risk and protective factors during and after pregnancy, BABIP will contribute to our understanding of the mechanisms by which prenatal environment influences infant development and health. Being the first such cohort from Turkey, it may also allow identification of prenatal risk and protective factors specific to the context and population in Turkey.