Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 5 de 5
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Intervalo de ano de publicação
1.
Cell ; 169(7): 1291-1302.e14, 2017 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-28602353

RESUMO

The emergence of sensory-guided behavior depends on sensorimotor coupling during development. How sensorimotor experience shapes neural processing is unclear. Here, we show that the coupling between motor output and visual feedback is necessary for the functional development of visual processing in layer 2/3 (L2/3) of primary visual cortex (V1) of the mouse. Using a virtual reality system, we reared mice in conditions of normal or random visuomotor coupling. We recorded the activity of identified excitatory and inhibitory L2/3 neurons in response to transient visuomotor mismatches in both groups of mice. Mismatch responses in excitatory neurons were strongly experience dependent and driven by a transient release from inhibition mediated by somatostatin-positive interneurons. These data are consistent with a model in which L2/3 of V1 computes a difference between an inhibitory visual input and an excitatory locomotion-related input, where the balance between these two inputs is finely tuned by visuomotor experience.


Assuntos
Desempenho Psicomotor , Córtex Visual/fisiologia , Animais , Retroalimentação Sensorial , Feminino , Interneurônios/citologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Neurônios/citologia , Optogenética , Estimulação Luminosa , Córtex Visual/citologia , Percepção Visual
2.
Cell Rep ; 36(10): 109669, 2021 09 07.
Artigo em Inglês | MEDLINE | ID: mdl-34496249

RESUMO

During navigation, animals estimate their position using path integration and landmarks, engaging many brain areas. Whether these areas follow specialized or universal cue integration principles remains incompletely understood. We combine electrophysiology with virtual reality to quantify cue integration across thousands of neurons in three navigation-relevant areas: primary visual cortex (V1), retrosplenial cortex (RSC), and medial entorhinal cortex (MEC). Compared with V1 and RSC, path integration influences position estimates more in MEC, and conflicts between path integration and landmarks trigger remapping more readily. Whereas MEC codes position prospectively, V1 codes position retrospectively, and RSC is intermediate between the two. Lowered visual contrast increases the influence of path integration on position estimates only in MEC. These properties are most pronounced in a population of MEC neurons, overlapping with grid cells, tuned to distance run in darkness. These results demonstrate the specialized role that path integration plays in MEC compared with other navigation-relevant cortical areas.


Assuntos
Potenciais de Ação/fisiologia , Córtex Entorrinal/fisiologia , Giro do Cíngulo/fisiologia , Percepção Visual/fisiologia , Animais , Neurônios/fisiologia , Córtex Visual Primário/fisiologia , Estudos Retrospectivos , Navegação Espacial/fisiologia
3.
Nat Commun ; 12(1): 671, 2021 01 28.
Artigo em Inglês | MEDLINE | ID: mdl-33510164

RESUMO

Neural circuits generate representations of the external world from multiple information streams. The navigation system provides an exceptional lens through which we may gain insights about how such computations are implemented. Neural circuits in the medial temporal lobe construct a map-like representation of space that supports navigation. This computation integrates multiple sensory cues, and, in addition, is thought to require cues related to the individual's movement through the environment. Here, we identify multiple self-motion signals, related to the position and velocity of the head and eyes, encoded by neurons in a key node of the navigation circuitry of mice, the medial entorhinal cortex (MEC). The representation of these signals is highly integrated with other cues in individual neurons. Such information could be used to compute the allocentric location of landmarks from visual cues and to generate internal representations of space.


Assuntos
Córtex Entorrinal/fisiologia , Rede Nervosa/fisiologia , Neurônios/fisiologia , Navegação Espacial/fisiologia , Percepção Visual/fisiologia , Algoritmos , Animais , Sinais (Psicologia) , Córtex Entorrinal/citologia , Movimentos Oculares/fisiologia , Feminino , Movimentos da Cabeça/fisiologia , Masculino , Camundongos da Linhagem 129 , Camundongos Endogâmicos C57BL , Modelos Neurológicos , Rede Nervosa/citologia
4.
Neuron ; 95(6): 1420-1432.e5, 2017 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-28910624

RESUMO

The cortex is organized as a hierarchical processing structure. Feedback from higher levels of the hierarchy, known as top-down signals, have been shown to be involved in attentional and contextual modulation of sensory responses. Here we argue that top-down input to the primary visual cortex (V1) from A24b and the adjacent secondary motor cortex (M2) signals a prediction of visual flow based on motor output. A24b/M2 sends a dense and topographically organized projection to V1 that targets most neurons in layer 2/3. By imaging the activity of A24b/M2 axons in V1 of mice learning to navigate a 2D virtual environment, we found that their activity was strongly correlated with locomotion and resulting visual flow feedback in an experience-dependent manner. When mice were trained to navigate a left-right inverted virtual environment, correlations of neural activity with behavior reversed to match visual flow. These findings are consistent with a predictive coding interpretation of visual processing.


Assuntos
Retroalimentação Sensorial/fisiologia , Locomoção/fisiologia , Córtex Motor/fisiologia , Vias Neurais/fisiologia , Córtex Visual/fisiologia , Animais , Feminino , Masculino , Camundongos , Camundongos Transgênicos
SELEÇÃO DE REFERÊNCIAS
Detalhe da pesquisa