RESUMO
We report a young woman suffering brief painful episodes in her right arm which sometimes spread to the whole right side of her body. The episodes were initially rare, but over 13 months they became increasingly frequent until occurring every 20 min. Neurological examination was normal. Magnetic resonance imaging revealed a lesion in the white matter of the parietal operculum. Lesions in the parietal operculum associated with persisting thalamic pain or loss of pain sensation have been reported, but rarely with episodic pain. Since episodic painful attacks have been described in association with various suprathalamic lesions, we conclude that paroxysmal pain attacks may be another consequence of the disturbance of the normal pattern of thalamocortical connections to the second sensory cortical area by a lesion, in our case, of the subcortical area of the parietal operculum.
Assuntos
Neoplasias Encefálicas/complicações , Dor/etiologia , Lobo Parietal , Periodicidade , Adulto , Eletroencefalografia , Feminino , Humanos , Imageamento por Ressonância MagnéticaRESUMO
Amphetamine hyperactivity, apomorphine stereotypy and haloperidol catalepsy were studied in rats following selective damage to cell bodies within the globus pallidus (GP). Ibotenic acid-induced bilateral lesions of GP attenuated the spontaneous locomotion of rats, but they did not influence the locomotor response to amphetamine. Apomorphine-induced gnawing and licking but not sniffing were attenuated in rats with GP lesions. The effect of haloperidol on catalepsy was enhanced following the GP lesion. It is concluded that the normal expression of some dopamine-related functions depends to a great degree on the integrity of cells within the GP region.
Assuntos
Comportamento Animal/fisiologia , Dopamina/fisiologia , Globo Pálido/fisiopatologia , Ácido Ibotênico/toxicidade , Oxazóis/toxicidade , Anfetaminas/toxicidade , Animais , Apomorfina/toxicidade , Comportamento Animal/efeitos dos fármacos , Catalepsia/induzido quimicamente , Lateralidade Funcional/fisiologia , Globo Pálido/efeitos dos fármacos , Globo Pálido/patologia , Haloperidol/toxicidade , Locomoção/efeitos dos fármacos , Masculino , Ratos , Ratos Endogâmicos , Técnicas Estereotáxicas , Comportamento Estereotipado/efeitos dos fármacos , Comportamento Estereotipado/fisiologiaRESUMO
The prevalence of CNS involvement of Adamantiadis-Behçet's syndrome (A-Bs) vary widely. Long-term follow-up studies of CNS involvement have rarely been reported. Five patients with CNS involvement, who were followed up from 2 to 9 years, are presented. Clinicolaboratory investigations (cerebrospinal fluid examination, electroencephalogram, brain CAT scan and MRI) were carried out. One patient had four and two patients had two attacks of CNS involvement with various clinical manifestations. The other two patients had a rather chronic course with a single slight CNS attack. Raised proteins and IgG were found in the CSF. Abnormal electroencephalographic findings were detected in three patients. Communicating hydrocephalus and various other abnormalities on CT scan and MRI were noted. All patients received corticosteroids and immunosuppressants during the attack period.