Detalhe da pesquisa
1.
Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.
J Biol Chem
; 298(8): 102209, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35779635
2.
High Throughput Experimentation and Continuous Flow Validation of Suzuki-Miyaura Cross-Coupling Reactions.
Chemistry
; 24(38): 9546-9554, 2018 Jul 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29920803
3.
Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells.
Biochim Biophys Acta Gen Subj
; 1861(1 Pt A): 3002-3010, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-27712973
4.
Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.
J Med Chem
; 64(1): 566-585, 2021 01 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33393767
5.
High-Throughput Experimentation and Continuous Flow Evaluation of Nucleophilic Aromatic Substitution Reactions.
ACS Comb Sci
; 22(4): 184-196, 2020 04 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32176474
6.
Aldol Reactions of Biorenewable Triacetic Acid Lactone Precursor Evaluated Using Desorption Electrospray Ionization Mass Spectrometry High-Throughput Experimentation and Validated by Continuous Flow Synthesis.
ACS Comb Sci
; 22(12): 796-803, 2020 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33211961
7.
High-throughput screening of organic reactions in microdroplets using desorption electrospray ionization mass spectrometry (DESI-MS): hardware and software implementation.
Anal Methods
; 12(28): 3654-3669, 2020 07 28.
Artigo
Inglês
| MEDLINE | ID: mdl-32701099
8.
Revisiting absorbance at 230nm as a protein unfolding probe.
Anal Biochem
; 389(2): 165-70, 2009 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19318083
9.
Screening of the Suzuki Cross-Coupling Reaction Using Desorption Electrospray Ionization in High-Throughput and in Leidenfrost Droplet Experiments.
J Am Soc Mass Spectrom
; 30(10): 2144-2151, 2019 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-31392703
10.
Cryo-electron microscopy structure and analysis of the P-Rex1-Gßγ signaling scaffold.
Sci Adv
; 5(10): eaax8855, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31663027
11.
High Throughput Experimentation Using DESI-MS to Guide Continuous-Flow Synthesis.
Sci Rep
; 9(1): 14745, 2019 10 14.
Artigo
Inglês
| MEDLINE | ID: mdl-31611590
12.
Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.
ACS Med Chem Lett
; 10(12): 1628-1634, 2019 Dec 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31857838
13.
Robotic hierarchical mixing for the production of combinatorial libraries of proteins and small molecules.
J Comb Chem
; 10(1): 63-8, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18072752
14.
High throughput reaction screening using desorption electrospray ionization mass spectrometry.
Chem Sci
; 9(6): 1647-1653, 2018 Feb 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29675211
15.
Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway.
Front Cell Infect Microbiol
; 7: 4, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28149831
16.
A Chemogenomic Screening Platform Used to Identify Chemotypes Perturbing HSP90 Pathways.
SLAS Discov
; 22(6): 706-719, 2017 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28346089
17.
Phenotypic profiling of Raf inhibitors and mitochondrial toxicity in 3D tissue using biodynamic imaging.
J Biomol Screen
; 19(4): 526-37, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24361645
18.
High-throughput secondary screening at the single-cell level.
J Lab Autom
; 18(1): 85-98, 2013 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-22968419
19.
Discovery of antagonists of tick dopamine receptors via chemical library screening and comparative pharmacological analyses.
Insect Biochem Mol Biol
; 42(11): 846-53, 2012 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23213654
20.
A "genome-to-lead" approach for insecticide discovery: pharmacological characterization and screening of Aedes aegypti D(1)-like dopamine receptors.
PLoS Negl Trop Dis
; 6(1): e1478, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-22292096