The validity of a computer-assisted simulation system for orthognathic surgery (CASSOS) for planning the surgical correction of class III skeletal deformities: single-jaw versus bimaxillary surgery.

The aim of this study was to assess the accuracy of the two-dimensional profile prediction produced by the computer-assisted simulation system for orthognathic surgery (CASSOS), for the correction of class III facial deformities. Correction was by maxillary advancement (n=17) or bimaxillary surgery (n=16). The mean age was 24 years (range 18-42). The surgical and dental movements obtained from the postoperative cephalogram were used to produce a CASSOS profile prediction, which was compared with the soft-tissue profile. The prediction was superimposed onto the postoperative radiograph, and a coordinate system was used to measure linear differences. For the maxillary advancement group there were statistical differences for three horizontal landmarks: superior labial sulcus (p=0.017), labrale superious (p=0.038) and labiomental fold (p=0.014). In the bimaxillary group only the landmark vertical labrale superious (p=0.002) showed a statistical difference. Generally, CASSOS produced useful profile predictions for maxillary advancement surgery or bimaxillary surgery for Class III patients, although there was considerable individual variation. The main areas of inaccuracy were the lips. The major difference between the two types of surgery was that most of the errors in the maxillary surgery group were in the horizontal direction, whilst for the bimaxillary surgery the errors were mainly in the vertical direction.

Towards building a photo-realistic virtual human face for craniomaxillofacial diagnosis and treatment planning.

The aim of this investigation was to assess the feasibility of building a virtual human face digitally by superimposing a photo-realistic three-dimensional (3D) soft-tissue surface on bone in the correct relationship and evaluating the registration errors associated with this method. The 3D soft-tissue surface of the face was captured using a fast stereophotogrammetry method and the underlying bone was recorded using a 3D computed tomography (CT) scanner. Using the Procrustes registration method, the outer surface of the 3D CT scan and the photo-realistic soft-tissue surfaces were merged into a single Virtual Reality Modelling Language (VRML) file and displayed using a standard VRML viewer. Quantitative measurements of registration errors were calculated in the reconstructed human head models using the signed closest point distance from the photo-realistic skin surface to the transformed CT skin surface. The registration errors between most parts of the aligned surfaces were within +/-1.5mm. The errors were relatively large around the eyebrows, eyelids and cheeks. Simultaneous recording of the face and skull may reduce this error.

3D assessment of morbidity associated with lower eyelid incisions in orbital trauma.

This study compared the morbidity associated with transconjunctival and transcutaneous approaches for orbital floor exploration with respect to the position of the lower eyelid following surgery. Two groups of 32 volunteers and 32 patients (12 transconjunctival and 20 transcutaneous) were recruited and three-dimensional (3D) imaging was carried out at 6 months following surgery. In the transcutaneous group, there were significant variations in the shape of the lower eyelid, with more medial displacement of the exocanthion. No significant differences were detected in the transconjunctival group compared to controls. The use of a 3D imaging system provided an objective method of assessing this aspect of morbidity associated with the use of lower eyelid incisions.

Skeletal stability after correction of maxillary hypoplasia by the Glasgow extra-oral distraction (GED) device.

Maxillary distraction osteogenesis delivers excellent results, particularly in patients with clefts. In the past, devices such as the conventional facemask and the rigid external distraction device have been used to correct maxillary hypoplasia after a Le Fort I osteotomy. We describe a new device, the Glasgow extra-oral distraction device. The extent of skeletal and dental stability of corrections achieved in 10 patients with maxillary hypoplasia associated with clefts was satisfactory. This device costs little, can be produced in developing countries, and provides effective treatment for severe secondary deformity associated with clefts.

Patients' responses to distraction osteogenesis: a multi-centre study.

This investigation aimed to compare and contrast practical difficulties experienced by 54 children from three different centres (Mexico City, New York, Paris) treated with either extra-oral or intra-oral distraction devices. The possible effect of distraction osteogenesis on pain/sleeping difficulty, speech and eating problems and disturbance of recreational activities and alteration in sensation were investigated. It was expected that intra-oral devices would reduce the difficulties associated with the distraction process and their psychological effect on the child. Some benefits resulting from the use of intra-oral devices were identified, these included fewer sleeping problems (P = 0.006) and less disturbance of recreational activities (P = 0.002). However, eating and maintaining oral hygiene were more problematic with intra-oral devices the differences between the intra-oral and extra-oral groups was approaching significance at P = 0.07. A major disadvantage of the extra oral device was scarring. In both groups the alteration of lip sensation was temporary, pain was limited to the time of activation of the distraction device. A high level of patients' cooperation was mandatory for successful completion of the treatment.

Mandibular elongation by automatic distraction osteogenesis: the first application in humans.

We report the case of a 65-year-old man who was the first person to have the right ramus of his mandible lengthened by 20mm by automatic continuous distraction osteogenesis. The device consists of two units: a component that is implanted into the bone, and an external component that is distant from the surgical site and mounted on a battery-driven portable syringe driver or infusion pump. A non-compressible drive cable connects the two.

The practicability of finite-element analysis for assessing changes in human craniofacial morphology from cephalographs.

The usefulness of a finite-element analytical (FEA) method for studying changes in facial form was investigated. The material was lateral cephalographs of 19 patients who had undergone surgical correction of the chin. FEA was used to assess changes in bony form brought about by surgery. Replicate digitization of cephalographic landmarks was used to minimize measurement error. Random and systematic errors were examined and their influence on the finite-element method was assessed. However, the sensitivity of FEA is such that the level of residual measurement error affects the reliability of the method and makes the technique unsuitable for individual cases. However, for pooled data from a group of cases the effect of measurement error is reduced and the reliability of the analysis is satisfactory for intergroup comparison.

Assessment of chin surgery by a coordinate free method.

A quantitative description of the changes and stability after genioplasty in a cross-sectional sample of 19 patients who had advancement genioplasty is presented. Euclidean distance matrix analysis (EDMA) of five cephalometric landmarks was used to assess these changes. During the first 6 months after surgery, bone deposition occurred at B point and pogonion, with bone resorption at the superior and posteroinferior aspects of the advanced segment. The genial segment rotated slightly anticlockwise. The authors believe this to be due to the action of the mentalis muscles. The stability of the advanced segment was excellent when assessed 1 year after surgery. The Euclidean distance matrix method can be used to assess shape changes and does not require cephalographic superimposition. It can also distinguish repositioning from remodelling and the changes of genioplasty from those of concomitant orthognathic surgery.

Mechanical testing of recombinant human bone morphogenetic protein-7 regenerated bone in sheep mandibles.

A new method was developed in this study for testing excised sheep mandibles as a cantilever. The method was used to determine the strength and stiffness of sheep hemi-mandibles including a 35 mm defect bridged by regenerated bone. Recombinant human bone morphogenetic protein-7 (rhBMP-7) in a bovine collagen type-I carrier was used for the bone regeneration. Initial tests on ten intact sheep mandibles confirmed that the strength, stiffness and area beneath the load-deformation curves of the right and left hemi-mandibles were not significantly different, confirming the validity of using the contra-lateral hemi-mandible as a control side. Complete bone regeneration occurred in six hemi-mandibles treated with rhBMP, but the quality and mechanical properties of the bone were very variable. The new bone in three samples contained fibrous tissue and was weaker and less stiff than the contra-lateral side (strength, 10-20 per cent; stiffness, 6-15 per cent). The other half had better-quality bone and was significantly stiffer and stronger (p < 0.05), with strength 45-63 per cent and stiffness 35-46 per cent of the contra-lateral side. Hemi-mandibles treated with collagen alone had no regenerated bone bridge suggesting that 35 mm is a critical-size bone defect.

A new device for microincremental automatic distraction osteogenesis.

We have invented a distraction device that can be placed intraorally and provides autodistraction. The device consists of two units: an implantable component that is applied directly on the bone, and an external component that is distant from the surgical site. The external component is mounted on a standard, battery-driven portable syringe driver or infusion pump. A fine flexible non-compressible tube connects the two. The compression of the bellows in the external component causes fluid to be forced through the connecting tube into the distraction component. The combination of the sealed system and incompressible fluid guarantees expansion of the bellows of the distraction component and gradually separates the bone segments.

Management of asymptomatic impacted wisdom teeth: a multicentre comparison.

This study was carried out to assess the opinions of clinicians (general practitioners and oral and maxillofacial surgeons) regarding the management of unerupted Mandibular Asymptomatic Impacted Wisdom Teeth (MAIWT) at two centres: Glasgow Dental Hospital and School and its affiliated institutions and Prince Philip Dental Hospital and its affiliated institutions in Hong Kong. Twenty four clinicians, twelve from each centre, of whom six were oral and maxillofacial surgeons (OMS) and six general dental practitioners (GDP) participated in this investigation. The orthopantomographs of 21 cases were used in the study and were examined by each clinician to investigate the management of unerupted MAIWT was recorded using a custom written questionnaire. Hong Kong clinicians showed a greater tendency towards extraction of MAIWT in comparison to Glasgow clinicians. The difference was statistically significant. The data indicates a significant difference between Hong Kong OMS and Glasgow OMS and between Hong Kong OMS and Hong Kong GDP, with Hong Kong OMS showing a greater tendency towards extraction. This study proved the diversity of opinions in one of the most common dento-alveolar procedures. The dilemma to extract or retain MAIWT still exists and controversy is likely to remain. The difference in the rationale of management regimes between the centres are discussed. The medico-legal and financial issues are investigated.

Evaluation of skeletal stability following surgical correction of mandibular prognathism.

This retrospective study was designed to assess skeletal stability after the correction of mandibular prognathism by sagittal split osteotomy (SSO) and intraoral vertical subsigmoid osteotomy (VSO). We used lateral cephalographs of 31 patients taken before, immediately after, and at least one year after the operation. We recorded euclidean distance matrix analysis, linear and angular measurements, and x and y co-ordinates of cephalometric landmarks for each cephalograph. There were no significant differences in extent of the mandibular retrognathia or magnitude of change between the two groups. The main significant changes in both groups were reduction of the total mandibular length, and posterior shifting in the mandible. One year after the operation the main change was the mean forward relapse of 2.5 mm in the SSO group and the mean posterior relapse of 0.5 mm in the VSO group. The difference in skeletal stability between the groups was significant (P< 0.05), and we conclude that VSO is the more effective technique for correcting mandibular prognathism.

Evaluation of changes following advancement genioplasty using finite element analysis.

This study examined skeletal stability and the remodelling process following advanced pedicled genioplasty. Twenty patients who had advancement genioplasty concomitant with other adjunctive orthognathic surgery were evaluated. A finite element analysis method was used to assess these changes. The stability of the advanced segment was excellent after 6 months. At 6 months bone remodelling was observed in the form of bone apposition at B point and Pogonion with bone resorption at the superior aspect of the advanced segment. The genial segment rotated about 12 degrees antero-superiorly which was thought to be due to the action of the mentalis muscle. Finite element analysis is a sensitive tool for assessing changes after genioplasty and was able to separate them from the effects of other adjunctive orthognathic surgery.

Assessment of zygomatico-orbital complex fractures using ultrasonography.

Twenty-two patients were referred to the maxillofacial surgical unit for assessment and management of suspected fractures of the zygomatico-orbital complex. In each case, both routine plain radiographic and ultrasound examinations were made. The aim of the study was to investigate the sensitivity and reliability of ultrasound to detect such fractures. Imaging with ultrasound was carried out at five areas: the infraorbital margin; lateral wall of the maxillary sinus; zygomatic arch; frontozygomatic process; and orbital floor. Both radiographic and ultrasound findings were correlated with the findings at operation. An overall agreement of 85% between radiographs and ultrasound scans was found. Ultrasound imaging was most reliable at the lateral wall of the maxillary sinus, where the sensitivity was 94% and specificity 100%. The positive predictive value at this area was 100% compared with radiographic findings. We conclude that ultrasound is a useful tool in imaging facial trauma as an initial investigation, and can help to reduce the total number of radiographs required for the diagnosis of fractures of the zygomatico-orbital complex.

Response of patients and families to lengthening of the facial bones by extraoral distraction osteogenesis: a review of 14 patients.

Fourteen patients or their immediate family were interviewed about their experiences of having either unilateral or bilateral external distraction osteogenesis of the mandible. The patients showed a high level of co-operation with treatment. Six of the 14 patients required repeat distractions, and had been informed and accepted that this was a possibility before the initial distraction. However, patients or their parents expressed some reservations about the extraoral distractors, which prevented them from practising their favourite sport and made them vulnerable to bullying by their friends and colleagues. Patients had moderate pain when the appliances were removed. They all expressed their satisfaction with the results and would recommend this treatment to others. Problems, including speech, eating, pain, and sleeping difficulties, were encountered by patients at all stages of treatment. Of considerable concern was the disruption of education when the child was treated during the school term.

A vision-based three-dimensional capture system for maxillofacial assessment and surgical planning.

We describe a vision-based three-dimensional facial data capture system designed for the planning of maxillofacial operations. We describe the system requirements and outline the methods used to develop a complete three-dimensional facial capture system. Our approach is based upon imaging the face using two stereo-pair sets of cameras. Scale-space-based stereo-matching is then used to recover correspondences between each of the captured stereo-pairs. Photogrammetric routines based on adjustment of bundles are used off-line to calibrate the system by imaging a single object that references all cameras to the same co-ordinate frame. This calibration scheme allows us to convert stereo correspondences to world points for each pair of cameras without the need for any subsequent fusion of data. Initial results show that we are able to capture key facial landmarks to within 0.5 mm.

Histological assessment of bioengineered new bone in repairing osteoperiosteal mandibular defects in sheep using recombinant human bone morphogenetic protein-7.

UNLABELLED: Numerous experimental studies have been published about osteoinductive bone morphogenetic proteins (BMPs). However, to our knowledge there has been no detailed histological study of a mandibular defect in a large mammal, reconstructed using BMPs. We describe here the histological features of rhBMP-7-induced bone in mandibular defects in sheep. METHODS: A 35 mm osteoperiosteal defect was created at the parasymphyseal region of the mandible in six adult sheep. The continuity of the mandible was maintained using a bony plate, and rhBMP-7 was applied on a type I collagen carrier. Bone labels were injected at selected time intervals during the follow-up period. The animals were killed after 3 months and bone samples were examined histologically, histomorphometrically, and by fluorescence microscopy. RESULTS AND CONCLUSIONS: We found a mixture of woven and lamellar bone that contained many cells with large nuclei. This had not reorganised to form cortical bone and the rhBMP-7-induced bone was more porous than the native bone. The newly-formed bone restored both endosteal and periosteal layers. rhBMP-7-induced bone was biocompatible and induced no ossification of soft tissue or abnormal growth of nearby vital structures. The mineral apposition rate was 1.98 microm/day (range 0.62-5.63 microm/day), a value close to that reported in humans. This suggests that BMPs have a limited effect in accelerating the rate of mineralisation, but promote the pre-mineralisation processes, and perhaps the formation of woven bone.

Preliminary assessment of skeletal stability after sagittal split mandibular advancement using a bioresorbable fixation system.

We studied skeletal stability during the first year after mandibular advancement and fixation with bioresorbable self-reinforced poly-L-lactide (SR-PLLA) screws in 11 patients by cephalometric measurements. We compared these with a cohort of 11 patients, in whom titanium screws were used for fixation. We found no significant difference between the two groups in the median preoperative cephalometric values and the median changes after operation. There was also no significant difference between the two groups regarding the median extent of relapse 1-year after operation. We conclude that bioresorbable SR-PLLA screws are comparable to metallic screws for fixation of bone after sagittal split mandibular advancement.

Stability of bimaxillary osteotomy following surgical correction of class II skeletal deformities: a two-centre study.

This study compares the stability following bimaxillary osteotomy for correction of class II skeletal deformities between two groups of patients. One group (15 patients) were treated at Canniesburn Hospital, West of Scotland Regional Plastic and Maxillofacial Unit, UK. The other group (15 patients) were treated at Ann Arbor Michigan University Hospital, USA. All cases were treated by Le Fort I maxillary advancement/impaction and bilateral sagittal split advancement osteotomy. In all cases Le Fort I maxillary osteotomy was more stable than sagittal split advancement osteotomy. The maxilla stayed within 1 mm of its immediate postoperative position. The average mandibular advancement in Canniesburn cases was 6 mm and about 4 mm in Michigan cases. During surgery the condyles were displaced about 2 mm posteriorly in Canniesburn cases, but remain in their anatomic position in Michigan cases. At 6 months following surgery, Canniesburn patients showed a clockwise mandibular relapse. This increased both the mandibular plane angle and ramus angle by 2.7 degrees and 2.9 degrees respectively. The mandible settled posteriorly 1.7 mm and inferiorly 1.5 mm. In Michigan cases the mandible stayed within 1 mm of its immediate postoperative position. The difference in mandibular relapse between the two groups was statistically significant (P < 0.05). The differences in the stability between the two groups are investigated and the theories of mandibular relapse following sagittal split osteotomy are discussed.

Segmental mandibular reconstruction by microincremental automatic distraction osteogenesis: an animal study.

We investigated the reconstruction of a surgically created critical size mandibular defect in sheep using a newly developed automatic distraction device. The device has an implantable component, which is fixed to the mandible to allow the transfer of the transport disc across the created defect, and an external component which is mounted on the activation pump and secured away from the site of bone distraction. Compression of the bellows in the external component causes fluid to be forced through the connecting tube into the distraction component. Distraction at a rate of 1 mm over 24 h was achieved in six sheep. New bone generated at the site of the created defects both anterior (compression side) and posterior (tension side) to the transport disc and had similar radiodensity to the adjacent mandibular bone eight weeks after the completion of distraction.