Detalhe da pesquisa
1.
A robust computational pipeline for model-based and data-driven phenotype clustering.
Bioinformatics
; 37(9): 1269-1277, 2021 06 09.
Artigo
Inglês
| MEDLINE | ID: mdl-33225350
2.
Role of Disease Progression Models in Drug Development.
Pharm Res
; 39(8): 1803-1815, 2022 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-35411507
3.
Opportunities for Systems Biology and Quantitative Systems Pharmacology to Address Knowledge Gaps for Drug Development in Pregnancy.
J Clin Pharmacol
; 63 Suppl 1: S96-S105, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37317502
4.
A pipeline for testing drug mechanism of action and combination therapies: From microarray data to simulations via Linear-In-Flux-Expressions: Testing four-drug combinations for tuberculosis treatment.
Math Biosci
; 360: 108983, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36931620
5.
A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis.
Front Pharmacol
; 14: 1272091, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-38239195
6.
Efficacy and tolerability of an endogenous metabolic modulator (AXA1125) in fatigue-predominant long COVID: a single-centre, double-blind, randomised controlled phase 2a pilot study.
EClinicalMedicine
; 59: 101946, 2023 May.
Artigo
Inglês
| MEDLINE | ID: mdl-37223439
7.
Quantitative system pharmacology as a legitimate approach to examine extrapolation strategies used to support pediatric drug development.
CPT Pharmacometrics Syst Pharmacol
; 11(7): 797-804, 2022 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35411657
8.
Quantifying cholesterol synthesis in vivo using (2)H(2)O: enabling back-to-back studies in the same subject.
J Lipid Res
; 52(7): 1420-8, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21498887
9.
Reconstruction of the Cytokine Signaling in Lysosomal Storage Diseases by Literature Mining and Network Analysis.
Front Cell Dev Biol
; 9: 703489, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34490253
10.
QSPcc reduces bottlenecks in computational model simulations.
Commun Biol
; 4(1): 1022, 2021 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34471226
11.
History and Future Perspectives on the Discipline of Quantitative Systems Pharmacology Modeling and Its Applications.
Front Physiol
; 12: 637999, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33841175
12.
A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat.
CPT Pharmacometrics Syst Pharmacol
; 9(7): 374-383, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32558397
13.
Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology.
CPT Pharmacometrics Syst Pharmacol
; 7(7): 442-452, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29920993
14.
Linear-In-Flux-Expressions Methodology: Toward a Robust Mathematical Framework for Quantitative Systems Pharmacology Simulators.
Gene Regul Syst Bio
; 11: 1177625017711414, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-29581702
15.
A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics.
Gene Regul Syst Bio
; 11: 1177625017710941, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28804243
16.
A cell-sparing electric field stimulation technique for high-throughput screening of voltage-gated ion channels.
Assay Drug Dev Technol
; 4(1): 21-35, 2006 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-16506886
17.
Discovery and Clinical Evaluation of MK-8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release.
J Am Heart Assoc
; 5(9)2016 08 25.
Artigo
Inglês
| MEDLINE | ID: mdl-27561272
18.
A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis.
Atherosclerosis
; 204(1): 55-65, 2009 May.
Artigo
Inglês
| MEDLINE | ID: mdl-19135672
19.
Segmentation of arterial vessel wall motion to sub-pixel resolution using M-mode ultrasound.
Annu Int Conf IEEE Eng Med Biol Soc
; 2008: 3138-41, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-19163372
20.
A one-dimensional model of blood flow in arteries with friction and convection based on the Womersley velocity profile.
Cardiovasc Eng
; 7(2): 51-73, 2007 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-17566860