Detalhe da pesquisa
1.
Effective treatment with the selective cytokine inhibitor BNZ-1 reveals the cytokine dependency of T-LGL leukemia.
Blood
; 142(15): 1271-1280, 2023 10 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37352612
2.
Identification of a γc Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21.
Gastroenterology
; 158(3): 625-637.e13, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31622625
3.
Common γ-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis.
Proc Natl Acad Sci U S A
; 112(35): 11030-5, 2015 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26283355
4.
Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum.
J Biol Chem
; 290(37): 22338-51, 2015 Sep 11.
Artigo
Inglês
| MEDLINE | ID: mdl-26183780
5.
Results From a First-in-Human Study of BNZ-1, a Selective Multicytokine Inhibitor Targeting Members of the Common Gamma (γc) Family of Cytokines.
J Clin Pharmacol
; 60(2): 264-273, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31465127
6.
IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability.
Leukemia
; 33(5): 1243-1255, 2019 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30353031
7.
Repression of IRF-4 target genes in human T cell leukemia virus-1 infection.
Oncogene
; 21(44): 6751-65, 2002 Oct 03.
Artigo
Inglês
| MEDLINE | ID: mdl-12360402
8.
Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease.
Immunogenetics
; 58(4): 252-8, 2006 May.
Artigo
Inglês
| MEDLINE | ID: mdl-16568261
9.
IFN regulatory factor 4 participates in the human T cell lymphotropic virus type I-mediated activation of the IL-15 receptor alpha promoter.
J Immunol
; 168(11): 5667-74, 2002 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12023365
10.
Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells.
J Immunol
; 169(6): 3120-30, 2002 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-12218129