Detalhe da pesquisa
1.
A Fast and Sensitive Method for the Detection of Leuprolide Acetate: A High-Throughput Approach for the In Vitro Evaluation of Liquid Crystal Formulations.
Anal Chem
; 88(9): 4613-8, 2016 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27040983
2.
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.
PLoS Pathog
; 10(5): e1004113, 2014 May.
Artigo
Inglês
| MEDLINE | ID: mdl-24854014
3.
Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.
J Virol
; 88(21): 12511-27, 2014 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-25142582
4.
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding.
Bioorg Med Chem Lett
; 23(22): 6172-7, 2013 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24080461
5.
Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.
J Virol
; 84(9): 4619-29, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-20181693
6.
The in vivo transformation and pharmacokinetic properties of a liquid crystalline drug delivery system.
Int J Pharm
; 532(1): 345-351, 2017 Oct 30.
Artigo
Inglês
| MEDLINE | ID: mdl-28844902
7.
X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design.
Sci Rep
; 7: 40292, 2017 01 12.
Artigo
Inglês
| MEDLINE | ID: mdl-28079137
8.
Formulation and characterization of a liquid crystalline hexagonal mesophase region of phosphatidylcholine, sorbitan monooleate, and tocopherol acetate for sustained delivery of leuprolide acetate.
Int J Pharm
; 514(1): 314-321, 2016 Nov 30.
Artigo
Inglês
| MEDLINE | ID: mdl-27863678
9.
The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.
Antiviral Res
; 115: 21-38, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25554382
10.
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.
Virology
; 450-451: 64-70, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24503068
11.
X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases.
J Med Chem
; 57(6): 2393-412, 2014 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24568342
12.
Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease.
J Med Chem
; 56(2): 534-46, 2013 Jan 24.
Artigo
Inglês
| MEDLINE | ID: mdl-23231439