Pesquisa | Secretaria de Estado da Saúde

1.

Somatic mutation rates scale with lifespan across mammals.

Cagan, Alex; Baez-Ortega, Adrian; Brzozowska, Natalia; Abascal, Federico; Coorens, Tim H H; Sanders, Mathijs A; Lawson, Andrew R J; Harvey, Luke M R; Bhosle, Shriram; Jones, David; Alcantara, Raul E; Butler, Timothy M; Hooks, Yvette; Roberts, Kirsty; Anderson, Elizabeth; Lunn, Sharna; Flach, Edmund; Spiro, Simon; Januszczak, Inez; Wrigglesworth, Ethan; Jenkins, Hannah; Dallas, Tilly; Masters, Nic; Perkins, Matthew W; Deaville, Robert; Druce, Megan; Bogeska, Ruzhica; Milsom, Michael D; Neumann, Björn; Gorman, Frank; Constantino-Casas, Fernando; Peachey, Laura; Bochynska, Diana; Smith, Ewan St John; Gerstung, Moritz; Campbell, Peter J; Murchison, Elizabeth P; Stratton, Michael R; Martincorena, Iñigo.

Nature ; 604(7906): 517-524, 2022 04.

Artigo Inglês | MEDLINE | ID: mdl-35418684

2.

Somatic mutation landscapes at single-molecule resolution.

Abascal, Federico; Harvey, Luke M R; Mitchell, Emily; Lawson, Andrew R J; Lensing, Stefanie V; Ellis, Peter; Russell, Andrew J C; Alcantara, Raul E; Baez-Ortega, Adrian; Wang, Yichen; Kwa, Eugene Jing; Lee-Six, Henry; Cagan, Alex; Coorens, Tim H H; Chapman, Michael Spencer; Olafsson, Sigurgeir; Leonard, Steven; Jones, David; Machado, Heather E; Davies, Megan; Øbro, Nina F; Mahubani, Krishnaa T; Allinson, Kieren; Gerstung, Moritz; Saeb-Parsy, Kourosh; Kent, David G; Laurenti, Elisa; Stratton, Michael R; Rahbari, Raheleh; Campbell, Peter J; Osborne, Robert J; Martincorena, Iñigo.

Nature ; 593(7859): 405-410, 2021 05.

Artigo Inglês | MEDLINE | ID: mdl-33911282

3.

Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils.

Kwon, Young Mi; Gori, Kevin; Park, Naomi; Potts, Nicole; Swift, Kate; Wang, Jinhong; Stammnitz, Maximilian R; Cannell, Naomi; Baez-Ortega, Adrian; Comte, Sebastien; Fox, Samantha; Harmsen, Colette; Huxtable, Stewart; Jones, Menna; Kreiss, Alexandre; Lawrence, Clare; Lazenby, Billie; Peck, Sarah; Pye, Ruth; Woods, Gregory; Zimmermann, Mona; Wedge, David C; Pemberton, David; Stratton, Michael R; Hamede, Rodrigo; Murchison, Elizabeth P.

PLoS Biol ; 18(11): e3000926, 2020 11.

Artigo Inglês | MEDLINE | ID: mdl-33232318

4.

Searching for transmissible cancers among the mussels of Europe.

Baez-Ortega, Adrian; Murchison, Elizabeth P.

Mol Ecol ; 31(3): 719-722, 2022 02.

Artigo Inglês | MEDLINE | ID: mdl-34918407

5.

Computational approaches for discovery of mutational signatures in cancer.

Baez-Ortega, Adrian; Gori, Kevin.

Brief Bioinform ; 20(1): 77-88, 2019 01 18.

Artigo Inglês | MEDLINE | ID: mdl-28968631

6.

IonGAP: integrative bacterial genome analysis for Ion Torrent sequence data.

Baez-Ortega, Adrian; Lorenzo-Diaz, Fabian; Hernandez, Mariano; Gonzalez-Vila, Carlos Ignacio; Roda-Garcia, Jose Luis; Colebrook, Marcos; Flores, Carlos.

Bioinformatics ; 31(17): 2870-3, 2015 Sep 01.

Artigo Inglês | MEDLINE | ID: mdl-25953799

7.

The evolution of two transmissible cancers in Tasmanian devils.

Stammnitz, Maximilian R; Gori, Kevin; Kwon, Young Mi; Harry, Edward; Martin, Fergal J; Billis, Konstantinos; Cheng, Yuanyuan; Baez-Ortega, Adrian; Chow, William; Comte, Sebastien; Eggertsson, Hannes; Fox, Samantha; Hamede, Rodrigo; Jones, Menna; Lazenby, Billie; Peck, Sarah; Pye, Ruth; Quail, Michael A; Swift, Kate; Wang, Jinhong; Wood, Jonathan; Howe, Kerstin; Stratton, Michael R; Ning, Zemin; Murchison, Elizabeth P.

Science ; 380(6642): 283-293, 2023 04 21.

Artigo Inglês | MEDLINE | ID: mdl-37079675

8.

Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule.

Bruzos, Alicia L; Santamarina, Martín; García-Souto, Daniel; Díaz, Seila; Rocha, Sara; Zamora, Jorge; Lee, Yunah; Viña-Feás, Alejandro; Quail, Michael A; Otero, Iago; Pequeño-Valtierra, Ana; Temes, Javier; Rodriguez-Castro, Jorge; Aramburu, Leyre; Vidal-Capón, André; Villanueva, Antonio; Costas, Damián; Rodríguez, Rosana; Prieto, Tamara; Tomás, Laura; Alvariño, Pilar; Alonso, Juana; Cao, Asunción; Iglesias, David; Carballal, María J; Amaral, Ana M; Balseiro, Pablo; Calado, Ricardo; El Khalfi, Bouchra; Izagirre, Urtzi; de Montaudouin, Xavier; Pade, Nicolas G; Probert, Ian; Ricardo, Fernando; Ruiz, Pamela; Skazina, Maria; Smolarz, Katarzyna; Pasantes, Juan J; Villalba, Antonio; Ning, Zemin; Ju, Young Seok; Posada, David; Demeulemeester, Jonas; Baez-Ortega, Adrian; Tubio, Jose M C.

Nat Cancer ; 4(11): 1575-1591, 2023 Nov.

Artigo Inglês | MEDLINE | ID: mdl-37783803

9.

Sex disparity in oronasal presentations of canine transmissible venereal tumour.

Strakova, Andrea; Baez-Ortega, Adrian; Wang, Jinhong; Murchison, Elizabeth P.

Vet Rec ; 191(5): e1794, 2022 09.

Artigo Inglês | MEDLINE | ID: mdl-35781651

10.

As cancer grows old.

Baez-Ortega, Adrian.

Science ; 374(6571): 1066, 2021 Nov 26.

Artigo Inglês | MEDLINE | ID: mdl-34822272

11.

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture.

Álvarez, Eva G; Demeulemeester, Jonas; Otero, Paula; Jolly, Clemency; García-Souto, Daniel; Pequeño-Valtierra, Ana; Zamora, Jorge; Tojo, Marta; Temes, Javier; Baez-Ortega, Adrian; Rodriguez-Martin, Bernardo; Oitaben, Ana; Bruzos, Alicia L; Martínez-Fernández, Mónica; Haase, Kerstin; Zumalave, Sonia; Abal, Rosanna; Rodríguez-Castro, Jorge; Rodriguez-Casanova, Aitor; Diaz-Lagares, Angel; Li, Yilong; Raine, Keiran M; Butler, Adam P; Otero, Iago; Ono, Atsushi; Aikata, Hiroshi; Chayama, Kazuaki; Ueno, Masaki; Hayami, Shinya; Yamaue, Hiroki; Maejima, Kazuhiro; Blanco, Miguel G; Forns, Xavier; Rivas, Carmen; Ruiz-Bañobre, Juan; Pérez-Del-Pulgar, Sofía; Torres-Ruiz, Raúl; Rodriguez-Perales, Sandra; Garaigorta, Urtzi; Campbell, Peter J; Nakagawa, Hidewaki; Van Loo, Peter; Tubio, Jose M C.

Nat Commun ; 12(1): 6910, 2021 11 25.

Artigo Inglês | MEDLINE | ID: mdl-34824211

12.

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.

Rodriguez-Martin, Bernardo; Alvarez, Eva G; Baez-Ortega, Adrian; Zamora, Jorge; Supek, Fran; Demeulemeester, Jonas; Santamarina, Martin; Ju, Young Seok; Temes, Javier; Garcia-Souto, Daniel; Detering, Harald; Li, Yilong; Rodriguez-Castro, Jorge; Dueso-Barroso, Ana; Bruzos, Alicia L; Dentro, Stefan C; Blanco, Miguel G; Contino, Gianmarco; Ardeljan, Daniel; Tojo, Marta; Roberts, Nicola D; Zumalave, Sonia; Edwards, Paul A; Weischenfeldt, Joachim; Puiggròs, Montserrat; Chong, Zechen; Chen, Ken; Lee, Eunjung Alice; Wala, Jeremiah A; Raine, Keiran M; Butler, Adam; Waszak, Sebastian M; Navarro, Fabio C P; Schumacher, Steven E; Monlong, Jean; Maura, Francesco; Bolli, Niccolo; Bourque, Guillaume; Gerstein, Mark; Park, Peter J; Wedge, David C; Beroukhim, Rameen; Torrents, David; Korbel, Jan O; Martincorena, Iñigo; Fitzgerald, Rebecca C; Van Loo, Peter; Kazazian, Haig H; Burns, Kathleen H; Campbell, Peter J.

Nat Genet ; 52(3): 306-319, 2020 03.

Artigo Inglês | MEDLINE | ID: mdl-32024998

13.

Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer.

Strakova, Andrea; Nicholls, Thomas J; Baez-Ortega, Adrian; Ní Leathlobhair, Máire; Sampson, Alexander T; Hughes, Katherine; Bolton, Isobelle A G; Gori, Kevin; Wang, Jinhong; Airikkala-Otter, Ilona; Allen, Janice L; Allum, Karen M; Arnold, Clara L; Bansse-Issa, Leontine; Bhutia, Thinlay N; Bisson, Jocelyn L; Blank, Kelli; Briceño, Cristóbal; Castillo Domracheva, Artemio; Corrigan, Anne M; Cran, Hugh R; Crawford, Jane T; Cutter, Stephen M; Davis, Eric; de Castro, Karina F; De Nardi, Andrigo B; de Vos, Anna P; Delgadillo Keenan, Laura; Donelan, Edward M; Espinoza Huerta, Adela R; Faramade, Ibikunle A; Fazil, Mohammed; Fotopoulou, Eleni; Fruean, Skye N; Gallardo-Arrieta, Fanny; Glebova, Olga; Gouletsou, Pagona G; Häfelin Manrique, Rodrigo F; Henriques, Joaquim J G P; Horta, Rodrigo S; Ignatenko, Natalia; Kane, Yaghouba; King, Cathy; Koenig, Debbie; Krupa, Ada; Kruzeniski, Steven J; Lanza-Perea, Marta; Lazyan, Mihran; Lopez Quintana, Adriana M; Losfelt, Thibault.

Nat Commun ; 11(1): 3059, 2020 06 16.

Artigo Inglês | MEDLINE | ID: mdl-32546718

14.

Whole-Exome Sequencing Identifies Somatic Mutations Associated With Mortality in Metastatic Clear Cell Kidney Carcinoma.

Mendoza-Alvarez, Alejandro; Guillen-Guio, Beatriz; Baez-Ortega, Adrian; Hernandez-Perez, Carolina; Lakhwani-Lakhwani, Sita; Maeso, Maria-Del-Carmen; Lorenzo-Salazar, Jose M; Morales, Manuel; Flores, Carlos.

Front Genet ; 10: 439, 2019.

Artigo Inglês | MEDLINE | ID: mdl-31156702

15.

Bacterial salivary microbiome associates with asthma among african american children and young adults.

Espuela-Ortiz, Antonio; Lorenzo-Diaz, Fabian; Baez-Ortega, Adrian; Eng, Celeste; Hernandez-Pacheco, Natalia; Oh, Sam S; Lenoir, Michael; Burchard, Esteban G; Flores, Carlos; Pino-Yanes, Maria.

Pediatr Pulmonol ; 54(12): 1948-1956, 2019 12.

Artigo Inglês | MEDLINE | ID: mdl-31496123

16.

Somatic evolution and global expansion of an ancient transmissible cancer lineage.

Baez-Ortega, Adrian; Gori, Kevin; Strakova, Andrea; Allen, Janice L; Allum, Karen M; Bansse-Issa, Leontine; Bhutia, Thinlay N; Bisson, Jocelyn L; Briceño, Cristóbal; Castillo Domracheva, Artemio; Corrigan, Anne M; Cran, Hugh R; Crawford, Jane T; Davis, Eric; de Castro, Karina F; B de Nardi, Andrigo; de Vos, Anna P; Delgadillo Keenan, Laura; Donelan, Edward M; Espinoza Huerta, Adela R; Faramade, Ibikunle A; Fazil, Mohammed; Fotopoulou, Eleni; Fruean, Skye N; Gallardo-Arrieta, Fanny; Glebova, Olga; Gouletsou, Pagona G; Häfelin Manrique, Rodrigo F; Henriques, Joaquim J G P; Horta, Rodrigo S; Ignatenko, Natalia; Kane, Yaghouba; King, Cathy; Koenig, Debbie; Krupa, Ada; Kruzeniski, Steven J; Kwon, Young-Mi; Lanza-Perea, Marta; Lazyan, Mihran; Lopez Quintana, Adriana M; Losfelt, Thibault; Marino, Gabriele; Martínez Castañeda, Simón; Martínez-López, Mayra F; Meyer, Michael; Migneco, Edward J; Nakanwagi, Berna; Neal, Karter B; Neunzig, Winifred; Ní Leathlobhair, Máire.

Science ; 365(6452)2019 08 02.

Artigo Inglês | MEDLINE | ID: mdl-31371581

17.

The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils.

Stammnitz, Maximilian R; Coorens, Tim H H; Gori, Kevin C; Hayes, Dane; Fu, Beiyuan; Wang, Jinhong; Martin-Herranz, Daniel E; Alexandrov, Ludmil B; Baez-Ortega, Adrian; Barthorpe, Syd; Beck, Alexandra; Giordano, Francesca; Knowles, Graeme W; Kwon, Young Mi; Hall, George; Price, Stacey; Pye, Ruth J; Tubio, Jose M C; Siddle, Hannah V T; Sohal, Sukhwinder Singh; Woods, Gregory M; McDermott, Ultan; Yang, Fengtang; Garnett, Mathew J; Ning, Zemin; Murchison, Elizabeth P.

Cancer Cell ; 33(4): 607-619.e15, 2018 04 09.

Artigo Inglês | MEDLINE | ID: mdl-29634948

18.

Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.

Rodriguez-Martin, Bernardo; Alvarez, Eva G; Baez-Ortega, Adrian; Zamora, Jorge; Supek, Fran; Demeulemeester, Jonas; Santamarina, Martin; Ju, Young Seok; Temes, Javier; Garcia-Souto, Daniel; Detering, Harald; Li, Yilong; Rodriguez-Castro, Jorge; Dueso-Barroso, Ana; Bruzos, Alicia L; Dentro, Stefan C; Blanco, Miguel G; Contino, Gianmarco; Ardeljan, Daniel; Tojo, Marta; Roberts, Nicola D; Zumalave, Sonia; Edwards, Paul A; Weischenfeldt, Joachim; Puiggròs, Montserrat; Chong, Zechen; Chen, Ken; Lee, Eunjung Alice; Wala, Jeremiah A; Raine, Keiran M; Butler, Adam; Waszak, Sebastian M; Navarro, Fabio C P; Schumacher, Steven E; Monlong, Jean; Maura, Francesco; Bolli, Niccolo; Bourque, Guillaume; Gerstein, Mark; Park, Peter J; Wedge, David C; Beroukhim, Rameen; Torrents, David; Korbel, Jan O; Martincorena, Iñigo; Fitzgerald, Rebecca C; Van Loo, Peter; Kazazian, Haig H; Burns, Kathleen H; Campbell, Peter J.

Nat Genet ; 55(6): 1080, 2023 Jun.

Artigo Inglês | MEDLINE | ID: mdl-36944736

19.

Streptococcal group B integrative and mobilizable element IMESag-rpsI encodes a functional relaxase involved in its transfer.

Lorenzo-Diaz, Fabian; Fernández-Lopez, Cris; Douarre, Pierre-Emmanuel; Baez-Ortega, Adrian; Flores, Carlos; Glaser, Philippe; Espinosa, Manuel.

Open Biol ; 6(10)2016 10.

Artigo Inglês | MEDLINE | ID: mdl-27707895

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