Validation of Monte Carlo multithreading TOpas 3.6 software in order to simulate the 6 MV Elekta Synergy MLCi2 platform linac.

Background: Monte Carlo simulation is generally appreciated as an extraordinary technique to investigate particle physics processes and interactions in nuclear medicine and Radiation Therapy. The present task validates a new methodology of Monte Carlo simulation based on the Multithreading technique to reduce CPU time to simulate a 6 MV photon beam provided by the Elekta Synergy MLCi2 platform medical linear accelerator treatment head utilizing TOpas version 3.6 Monte Carlo software and the Slurm Marwan cluster. Materials and methods: The simulation includes the linear accelerator (LINAC) major components. Calculations are performed for the photon beam with several treatment field sizes varying from 3 × 3 to 10 × 10 cm2 at a 100 cm of distance from the source to the surface of the IBA dosimetry water box. The simulation was wholly approved by comparison with experimental distributions. To evaluate simulation accuracy, gamma index formalism for (2%/2mm) and (3%/2mm) criteria, Distance To Agreement DTA, and the estimator standard error ɛ and ɛ max are used. Results: Good agreement between simulations and measurements was observed for depth doses and lateral dose profiles, respectively. The gamma index comparisons also highlighted this agreement; more than 97% of the points for all simulations satisfy the quality assurance criteria of (2%/2mm). Regarding calculation performance, the event processing speed is faster using Gate-[mp] compared to TOpas-[mt] mode when running the identical simulation code for both. Conclusions: Consequently, according to the achieved results, the proposed methodology shows the first validation of TOpas in radiotherapy linacs simulations and a reduction in calculation time, capping simulation accuracy as much as possible. For this reason, this software is recommended to be serviceable for Treatment Planning Systems (TPS) purposes.

Monte Carlo evaluation of particle interactions within the patient-dependent part of Elekta 6 MV photon beam applying IAEA phase space data.

BACKGROUND: This work aims to provide a simulated method to be used by designers of medical accelerators and in clinical centers to manage and minimize particles' interaction in the patient-dependent part of a 6 MV X-Ray Beam generated by the Elekta linear accelerator system, based on the latest GATE software version 9.0 Monte Carlo simulation, IAEA phase space data, and the last version of "Slurm" computing cluster. MATERIALS AND METHODS: The experimental results are obtained using the Elekta 6 MV accelerator. The simulation MC developed includes the majority of the patient-dependent segments, such as Multi-Leaf Collimator (MLC), Tongue and Groove T&G, Rounded leaf Part, including the Jaws (XY). This model is used, with a simulated Iba Blue Phantom 2 homogeneous water phantom with dimensions 480 × 480 × 410 mm3, positioned at a Source-to-Surface-Distance (SSD) of 100 cm, all of the interactions of the mega voltage 6 MV radiations in water are simulated. The IAEA phase space (PS) provided by the International Atomic Energy Agency database and cluster computing (Slurm HPC-MARWAN, CNRST, Morocco) are employed to reduce our simulation time. RESULTS: The results confirm that there are many interactions in all areas and the patient-dependent part's internal structures. Thus, electrons and positrons participation appear in the generated field previously designed to be an X-ray beam. Besides, to validate our implementation geometry, the PDD's and transverse profiles, at a depth ranging from 1.5 to 20 cm, for a field size of 10 × 10 cm2, the beam quality such as D 10%, d max (cm), d 80 (cm), TPR (20/10) , the two relative differences in dose were derived on σ i and σ i,max are calculated, respectively. Additionally, gamma index formalism for 2%/2 mm criteria is used. Once and for all, we typically take a good agreement between simulation MC GATE 9.0 and the experiment data with an error less than 2%/2 mm. CONCLUSIONS: In the field of X-ray photons, a significant contribution of electrons and positrons has been found. This contribution could be enough to be essential or affect the delivered dose. A good agreement of 98% between this new approach of simulation MC GATE 9.0 software based on IAEA phase space and experimental dose distributions is observed regarding the validation tests used in this task.

Dosimetric study of Hounsfield number correction effect in areas influenced by contrast product in lungs case.

BACKGROUND: The aim of the study was dosimetric effect quantification of exclusive computed tomography (CT) use with an intravenous (IV) contrast agent (CA ), on dose distribution of 3D-CRT treatment plans for lung cancer. Furthermore, dosimetric advantage investigation of manually contrast-enhanced region overriding, especially the heart. MATERIALS AND METHODS: Ten patients with lung cancer were considered. For each patient two planning CT sets were initially taken with and without CA. Treatment planning were optimized based on CT scans without CA. All plans were copied and recomputed on scans with CA. In addition, scans with IV contrast were copied and density correction was performed for heart contrast enhanced. Same plans were copied and replaced to undo dose calculation errors that may be caused by CA. Eventually, dosimetric evaluations based on dose volume histograms (DVHs) of planning target volumes (PTV) and organs at-risk were studied and analyzed using the Wilcoxon's signed rank test. RESULTS: There is no statistically significant difference in dose calculation for the PTV maximum, mean, minimum doses, spinal cord maximum doses and lung volumes that received 20 and 30 Gy, between planes calculated with and without contrast scans (p > 0.05) and also for contrast scan, with manual regions overriding. CONCLUSIONS: Dose difference caused by the contrast agent is negligible and not significant. Therefore, there is no justification to perform two scans, and using an IV contrast enhanced scan for dose calculation is sufficient.

A comparative study of boost dose delivery techniques in breast cancer radiotherapy optimising efficacy and minimising toxicity.

The present study aims to compare three techniques for delivering a boost absorbed dose: conventional reduced tangential (3D), volumetric modulated arc therapy (VMAT) and fields forward-planned technique boost (3DF). The study included 15 postoperative breast cancer patients who received a boost absorbed dose following breast-conserving surgery. The conformity index and homogeneity index were used to evaluate treatment outcomes, along with the average absorbed dose received by organs at risk (OAR). All the calculated dosimetric plans are carried out using Monaco Treatment Planning System (TPS). VMAT offers superior conformity, dose homogeneity and target coverage, it is associated with higher absorbed doses to OAR such as the heart and lung. In contrast, the 3D and 3DF techniques exhibit advantages in reducing absorbed doses to critical structures, potentially minimising the risk of cardiac and pulmonary complications. Each technique has its advantages and disadvantages. The choice of technique should be individualised, taking into account patient-specific factors and treatment goals and involves a multidisciplinary approach.

Impact of the anode tilt on photon emission spectrum and temperature rise in an x-ray tube.

In radiology, the photon fluence and the energy spectrum generated from an x-ray tube may depend on the anode tilt angle. In this contribution, a Monte Carlo investigation is performed to quantify this effect by modeling an x-ray tube based on published data Bujila R.et al(2020Physica. Med.7544-54). The GATE simulation code is used for this purpose. The calculations have moreover confirmed this dependence; the tilt of the anode could be used to increase the photon fluence. The thermal analysis has shown that the hot spot size is dependent as well on the anode tilt angle. The thermal focus temperature (ΔT) decreases when the anode tilt angle increases. Finally, by moving the acquisition angle from 293°-337° to 248°-292° and changing the anode tilt angle from 8° to 28°, the photon fluence can be increased by 55%.

Implementation of a new virtual source model in Gate 9.0 package to simulate Elekta Synergy MLCi2 6 MV accelerator.

Monte Carlo simulation is appreciated as an extraordinary technique to investigate particle physic processes in Radiation Therapy. This task offers a new Virtual Source Model (VSM) based on an innovative reconstruction method to extract energy and angular distribution from the Python phase space output data. Extensive comparisons of dose distributions are performed to evaluate VSM simulation precision. Four squared field configurations extending from 3 × 3 to 20 × 20 cm2are chosen for dose calculation to test field size and symmetry influences. To evaluate simulation accuracy, the beam quality parameters (such asD10(%),dmax(cm),d80(cm), andTPR(20/10)) also validation tests (gamma index formalism for 2%/2 mm criteria, Distance To Agreement DTA, and the estimator standard error (ϵ,ϵmax)) are determined. Good agreement is achieved in terms of beam quality parameters and validation tests for each evaluated beam size, within a computation time of 58 hours and 17 hours on 20 nodes (presents 160 CPUs) of the full simulation and the VSM, respectively. This advanced VSM generated for the Elekta Synergy MLCi2 platform displays an uncomplicated approach. It is a great example of reconstructing different x-ray beams of various linac accelerators to facilitate its integration in cancer treatment.