Detalhe da pesquisa
1.
GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture.
Antimicrob Agents Chemother
; 65(5)2023 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33619061
2.
Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells.
PLoS Pathog
; 11(11): e1005233, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26539983
3.
Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.
PLoS Pathog
; 10(4): e1004071, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24722454
4.
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors.
Antimicrob Agents Chemother
; 55(6): 2905-15, 2011 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-21464257
5.
Evaluation of Broadly Neutralizing Antibody Sensitivity by Genotyping and Phenotyping for Qualifying Participants to HIV Clinical Trials.
J Acquir Immune Defic Syndr
; 88(1): 61-69, 2021 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34397744
6.
A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro.
J Biol Chem
; 284(49): 33883-93, 2009 Dec 04.
Artigo
Inglês
| MEDLINE | ID: mdl-19822521
7.
A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19.
Nat Commun
; 11(1): 5214, 2020 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33060595
8.
A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19.
bioRxiv
; 2020 Jun 23.
Artigo
Inglês
| MEDLINE | ID: mdl-32607511
9.
A succession of mechanisms stimulate efficient reconstituted HIV-1 minus strand strong stop DNA transfer.
Biochemistry
; 48(8): 1810-9, 2009 Mar 03.
Artigo
Inglês
| MEDLINE | ID: mdl-19192967
10.
Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis.
Bioorg Med Chem Lett
; 18(3): 1131-4, 2008 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18083512
11.
Evidence that creation of invasion sites determines the rate of strand transfer mediated by HIV-1 reverse transcriptase.
J Mol Biol
; 363(5): 878-90, 2006 Nov 10.
Artigo
Inglês
| MEDLINE | ID: mdl-16997325
12.
Effects of donor and acceptor RNA structures on the mechanism of strand transfer by HIV-1 reverse transcriptase.
J Mol Biol
; 353(4): 772-87, 2005 Nov 04.
Artigo
Inglês
| MEDLINE | ID: mdl-16216274
13.
Author Correction: A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19.
Nat Commun
; 12(1): 3984, 2021 Jun 21.
Artigo
Inglês
| MEDLINE | ID: mdl-34155200
14.
Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.
PLoS One
; 8(9): e74163, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-24040198
15.
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
J Med Chem
; 52(19): 5781-4, 2009 Oct 08.
Artigo
Inglês
| MEDLINE | ID: mdl-19791799
16.
Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect.
J Biol Chem
; 283(14): 9196-205, 2008 Apr 04.
Artigo
Inglês
| MEDLINE | ID: mdl-18218634
17.
Insights into the multiple roles of pausing in HIV-1 reverse transcriptase-promoted strand transfers.
J Biol Chem
; 282(9): 6222-31, 2007 Mar 02.
Artigo
Inglês
| MEDLINE | ID: mdl-17204480
18.
Reduced dNTP interaction of human immunodeficiency virus type 1 reverse transcriptase promotes strand transfer.
J Biol Chem
; 281(43): 32113-21, 2006 Oct 27.
Artigo
Inglês
| MEDLINE | ID: mdl-16926150
19.
Stimulation of HIV-1 minus strand strong stop DNA transfer by genomic sequences 3' of the primer binding site.
J Biol Chem
; 281(34): 24227-35, 2006 Aug 25.
Artigo
Inglês
| MEDLINE | ID: mdl-16782713
20.
Evidence that HIV-1 reverse transcriptase employs the DNA 3' end-directed primary/secondary RNase H cleavage mechanism during synthesis and strand transfer.
J Biol Chem
; 280(49): 40534-43, 2005 Dec 09.
Artigo
Inglês
| MEDLINE | ID: mdl-16221683