Detalhe da pesquisa
1.
A Photoaffinity-Based Fragment-Screening Platform for Efficient Identification of Protein Ligands.
Angew Chem Int Ed Engl
; 59(47): 21096-21105, 2020 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-32745361
2.
Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors.
Bioorg Med Chem Lett
; 27(17): 4034-4038, 2017 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28774425
3.
A Chemical Probe for the ATAD2 Bromodomain.
Angew Chem Int Ed Engl
; 55(38): 11382-6, 2016 09 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27530368
4.
Tyrosine Kinase Inhibitors Display Potent Activity against Cryptosporidium parvum.
Microbiol Spectr
; 11(1): e0387422, 2023 02 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36533912
5.
Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.
ACS Med Chem Lett
; 14(9): 1231-1236, 2023 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37736196
6.
5-Aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors.
Bioorg Med Chem Lett
; 22(5): 1989-94, 2012 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22310227
7.
GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor.
Bioorg Med Chem Lett
; 22(17): 5625-9, 2012 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22863203
8.
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.
Bioorg Med Chem Lett
; 22(16): 5222-6, 2012 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22801646
9.
Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).
Bioorg Med Chem Lett
; 22(8): 2968-72, 2012 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22437115
10.
Transcatheter Aortic Valve Implantation for Severe Pure Aortic Regurgitation With Dedicated Devices.
Interv Cardiol
; 17: e11, 2022 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-35923768
11.
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432.
J Med Chem
; 65(22): 15174-15207, 2022 11 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36378954
12.
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
J Med Chem
; 65(1): 633-664, 2022 01 13.
Artigo
Inglês
| MEDLINE | ID: mdl-34928601
13.
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate.
J Med Chem
; 65(3): 2262-2287, 2022 02 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34995458
14.
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3ß inhibitors.
Bioorg Med Chem Lett
; 21(16): 4823-7, 2011 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21764580
15.
3,5-Disubstituted-indole-7-carboxamides: the discovery of a novel series of potent, selective inhibitors of IKK-ß.
Bioorg Med Chem Lett
; 21(8): 2255-8, 2011 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21429745
16.
Expanding Bromodomain Targeting into Neglected Parasitic Diseases.
ACS Infect Dis
; 7(11): 2953-2958, 2021 11 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34612618
17.
Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors.
ACS Med Chem Lett
; 12(8): 1308-1317, 2021 Aug 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34413961
18.
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(6): 3249-3281, 2021 03 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33662213
19.
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(15): 10772-10805, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34255512
20.
Targeting IKKß for the treatment of rheumatoid arthritis.
Drug News Perspect
; 23(8): 483-90, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-21031164