Assuntos
Dermoscopia/normas , Necrobiose Lipoídica/diagnóstico por imagem , Necrobiose Lipoídica/patologia , Ultrassonografia/normas , Idoso , Dermoscopia/métodos , Diabetes Mellitus Tipo 2/complicações , Erros de Diagnóstico/prevenção & controle , Eritema/patologia , Feminino , Humanos , Necrobiose Lipoídica/tratamento farmacológico , Pentoxifilina/administração & dosagem , Pentoxifilina/uso terapêutico , Inibidores de Fosfodiesterase/uso terapêutico , Ultrassonografia/métodosRESUMO
Tophi develop during the most advanced clinical stage of gout, and are usually located on or around the joints. However, unusual skin features caused by intradermal and/or subcutaneous deposition of tophaceous material at locations other than articular regions have been reported. We present the case of a patient with a condition that has been recently termed 'miliarial gout'. which is only the second such case, to our knowledge. A 51-year-old woman, who had a chronic joint disease that had been diagnosed and treated as psoriatic arthritis, presented with multiple asymptomatic, yellowish-white, firm papules (1-3 mm in size) on erythematous areas on the outside of her left leg. On histological examination of a skin biopsy, uric acid crystals were seen in the dermis and subcutis. The patient also had a raised level of serum urate, consistent with a diagnosis of gout. Treatment with allopurinol led to rapid improvement. Intake of corticosteroids and diuretics was a possible triggering factor for the development of cutaneous tophi in this patient.
Assuntos
Artrite Gotosa/complicações , Artrite Psoriásica/complicações , Dermatopatias/etiologia , Ácido Úrico/metabolismo , Feminino , Humanos , Perna (Membro) , Pessoa de Meia-IdadeRESUMO
Giant basal cell carcinoma (BCC) is defined as a tumor with a diameter of 5 cm or more. Surgery, the treatment of choice for any type of BCC, can cause considerable anatomical damage in large tumors. In 2 patients with giant BCC we therefore provided neoadjuvant treatment with a combination of oral acitretin and topical 5% imiquimod. Acitretin is a systemic retinoid used for primary prevention of nonmelanoma skin cancer. Imiquimod is an immunomodulator whose approved indications include treatment of nonfacial superficial BCC less than 2 cm in diameter. Previous studies have demonstrated a synergic anticancer effect of both drugs in vitro and in vivo. This combination produced a marked reduction in tumor mass in our patients. Later we were able to provide definitive treatment, which achieved complete remission of the tumors.
Assuntos
Acitretina/uso terapêutico , Aminoquinolinas/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma Basocelular/tratamento farmacológico , Neoplasias Faciais/tratamento farmacológico , Terapia Neoadjuvante , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Torácicas/tratamento farmacológico , Acitretina/administração & dosagem , Administração Cutânea , Administração Oral , Idoso , Aminoquinolinas/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Carcinoma Basocelular/complicações , Carcinoma Basocelular/radioterapia , Carcinoma Basocelular/cirurgia , Terapia Combinada , Neoplasias Faciais/complicações , Neoplasias Faciais/radioterapia , Feminino , Humanos , Imiquimode , Psoríase/complicações , Indução de Remissão , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/radioterapia , Neoplasias Cutâneas/cirurgia , Úlcera Cutânea/etiologia , Neoplasias Torácicas/complicações , Neoplasias Torácicas/cirurgiaRESUMO
BACKGROUND: Gastrointestinal stromal tumors have been detected in 25% of the necropsies performed on NF1 patients, but have been reported only in 7% of NF1 patients in the largest series. Such data imply an important gap between the true presence of tumors and those diagnosed. Few genotype-phenotype relationships have been described but to date none referring to abdominal tumors. OBJECTIVES: Evaluate retrospectively the efficacy of a regular and proactive follow-up of NF1 patients to early diagnose abdominal tumors and report their mutations. METHODS: Cohort study performed between 2010 and 2020, with 43 NF1 adult patients followed at our Dermatology department. RESULTS: Eight abdominal tumors were diagnosed in six patients, meaning that 14% of the followed patients developed an abdominal tumor. Five patients (83%) were asymptomatic. Five (83.3%) had a family history of NF1 with abdominal tumors (patients 1,2 and 3,4,5 were relatives). CONCLUSIONS: Although currently gastrointestinal routine screening investigations for asymptomatic patients are not recommended in the guidelines, the family aggregation in our series suggests it should be considered a close follow-up of the relatives of a patient with an NF1-related abdominal tumor. Also, for the first time, two mutations [c.2041C > T (p.Arg681Ter) and c.4537C > T (p.Arg1513*)] have been associated with family aggregation of abdominal tumors in NF1 patients.
Assuntos
Neoplasias Abdominais , Neurofibromatose 1 , Neoplasias Abdominais/complicações , Neoplasias Abdominais/genética , Estudos de Coortes , Genótipo , Humanos , Neurofibromatose 1/complicações , Neurofibromatose 1/genética , Neurofibromatose 1/patologia , Fenótipo , Estudos RetrospectivosRESUMO
Somatostatin analogues (SAs) are potential anticancer agents. This study was designed to investigate the expression of somatostatin receptors (SSTRs) in melanoma cells and the effect of two SAs on cell proliferation and viability. Eighteen primary and metastatic human cutaneous melanoma cell lines were treated with octreotide and SOM230. Expression of SSTR1, SSTR2, SSTR3 and SSTR5 was assessed by real-time polymerase chain reaction. Proliferation, viability and cell death were assessed using standard assays. Inhibition was modelled by mixed-effect regression. Melanoma cells expressed one or more SSTR. Both SAs inhibited proliferation of most melanoma cell lines, but inhibition was < 50%. Neither SA affected cell viability or induced cell death. The results suggest that melanoma cell lines express SSTRs. The SAs investigated, under the conditions used in this study, did not, however, significantly inhibit melanoma growth or induce cell death. Novel SAs, combination therapy with SAs and their anti-angiogenic properties should be further investigated.
Assuntos
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Melanoma/genética , Melanoma/patologia , Octreotida/farmacologia , Receptores de Somatostatina/genética , Somatostatina/análogos & derivados , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Humanos , Receptores de Somatostatina/metabolismo , Somatostatina/farmacologiaAssuntos
Hamartoma/diagnóstico , Doenças Retinianas/diagnóstico , Tomografia de Coerência Óptica/métodos , Catarata/complicações , Catarata/terapia , Extração de Catarata , Diagnóstico Diferencial , Feminino , Angiofluoresceinografia , Fundo de Olho , Hamartoma/complicações , Hamartoma/patologia , Humanos , Achados Incidentais , Pessoa de Meia-Idade , Doenças Retinianas/complicações , Doenças Retinianas/patologia , Oclusão da Veia Retiniana/complicações , Oclusão da Veia Retiniana/cirurgia , EspanhaRESUMO
The clinical and histologic features of 375 cases of primary malignant melanomas of the skin diagnosed and/or treated in the Hospital Clinic i Provincial (Barcelona, Spain) over a seven years period (1981-1987) were evaluated. The analysis of data showed many differences between these cases and those previously reported by us or from other countries. Sex incidence showed an increased frequency in women (58%), and a high incidence on lower limb in female (26% of all cases). Superficially spreading melanoma was the most common type (58%), followed by nodular melanoma (27%), acral lentiginous melanoma (8%) and lentigo maligna melanoma (6%). 57% of cases were diagnosed when the tumor thickness indicated a moderate or high-risk.
Assuntos
Melanoma/patologia , Neoplasias Cutâneas/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
Two cases of flat warts spontaneous regression syndrome are reported, with description of the histopathologic features. Immunologic mechanism which intervene in the processus are reviewed.
Assuntos
Dermatopatias/fisiopatologia , Verrugas/fisiopatologia , Adulto , Feminino , Humanos , Inflamação , Prurido/etiologia , Dermatopatias/patologia , Síndrome , Verrugas/patologiaRESUMO
We report a case of a 57 year-old male who developed atypical bullous disease and in whom an underlying carcinoma of the bronchus was found. The cutaneous eruption fulfilled the clinical, histological and immunological features of pemphigus herpetiformis. Reports of pemphigus herpetiformis and internal malignancy are extremely rare.
Assuntos
Carcinoma de Células Pequenas/complicações , Neoplasias Pulmonares/complicações , Pênfigo/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Pênfigo/patologiaRESUMO
A case of clinically characteristic hypersensitivity reaction to phenytoin in a AIDS patient with cerebral toxoplasmosis is reported. There was response to therapy with systemic steroids. Laboratory data and histopathologic features of the skin are reported.
Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Toxidermias/etiologia , Hidantoínas/efeitos adversos , Adulto , Toxidermias/complicações , Toxidermias/patologia , Feminino , HumanosRESUMO
Dermatoweb is a website to aid undergraduate dermatology training. It includes the dermatology program of the Lerida Faculty of Medicine, and is based principally on clinical presentations, tables with the differential diagnosis of the 20 most common reasons for dermatologic consultation, about 200 clinical test cases to stimulate self-training, and a subject list with the 32 topics that make up the dermatology syllabus in many faculties of medicine. Thanks to this website, some of our students achieve high marks in dermatology despite hardly coming to classes. In addition, therapeutic guidelines for the common dermatoses can be found on the site, and an atlas with more than 5,300 photographs and almost 100 videos on the more common dermatological procedures; these can serve as a visual aid for family doctors, residents in dermatology in the initial years, and practicing dermatologists.
Assuntos
Dermatologia/educação , Educação de Graduação em Medicina/métodos , InternetRESUMO
BACKGROUND AND OBJECTIVES: Pediatric dermatology is a relatively new subspecialty for which few epidemiological studies are available. We aimed to determine the work load associated with this subspecialty and the most common presenting complaints among pediatric patients in the general dermatology clinic of our hospital. METHODS: A descriptive study was performed based on hospital records to analyze patients aged 16 years or under seen in our department in 2005 and their diagnoses. RESULTS: Pediatric dermatology accounts for 12.1 % of the work load in our department (1,329/10,998 patients were Assuntos
Dermatopatias/epidemiologia
, Adolescente
, Criança
, Pré-Escolar
, Hospitais Universitários
, Humanos
, Lactente
, Espanha
RESUMO
We present the case of a newborn with congenital absence of skin in the anterior part of the left leg that shortly after developed bulla and erosions in hands, feet, ears, buttocks and mouth. The cutaneous biopsy and ultrastructural and immunohistochemical studies showed a subepidermal bulla in the lamina lucida, absence of hemidesmosomes and marked decrease of laminin 5, thus establishing the diagnosis of Bart syndrome associated to the Herlitz form of lethal junctional epidermolysis bullosa. Bart syndrome consists of congenital and localized absence of skin, nail abnormalities and mucoc-cutaneous bullae. It is usually associated to dystrophic epidermolysis bullosa. The Herlitz form of junctional epidermolysis bullosa is a rare variant, usually lethal that is produced by mutations in the genes coding for the anchor protein laminin 5. To our knowledge this is the second case that reports an association between Bart syndrome and lethal junctional epidermolysis bullosa and the first in which the results of immunofluorescence mapping are published.
Assuntos
Epidermólise Bolhosa Juncional/complicações , Unhas Malformadas/complicações , Anormalidades da Pele/complicações , Dermatopatias Vesiculobolhosas/complicações , Colágeno Tipo VII/análise , Colágeno Tipo VII/genética , Epidermólise Bolhosa Juncional/patologia , Evolução Fatal , Hemidesmossomos/ultraestrutura , Humanos , Recém-Nascido , Laminina/análise , Laminina/deficiência , Laminina/genética , Masculino , Microscopia de Fluorescência , Sepse/etiologia , Anormalidades da Pele/genética , Anormalidades da Pele/patologia , Dermatopatias Vesiculobolhosas/congênito , Dermatopatias Vesiculobolhosas/patologia , SíndromeRESUMO
A case of cutaneous malakoplakia in a 44-year-old women under immunosuppressive therapy after renal transplantation for nephrosclerosis is reported. A nodular lesion with inflammatory signs appeared on her right buttock. Histopathology showed a dermal infiltrate with histiocytes containing Michaelis-Gutmann bodies. Electron microscopy showed Michaelis-Gutmann bodies with concentric laminar structure ('target' appearance). Tissue culture revealed Escherichia coli growth. Lesions recurred on surrounding skin and left buttock after excision. Clofazimine treatment resulted in total remission.
Assuntos
Malacoplasia/patologia , Dermatopatias/patologia , Adulto , Clofazimina/uso terapêutico , Infecções por Escherichia coli , Feminino , Histiócitos/patologia , Humanos , Terapia de Imunossupressão , Transplante de Rim , Malacoplasia/tratamento farmacológico , Malacoplasia/etiologia , Dermatopatias/tratamento farmacológico , Dermatopatias/etiologiaRESUMO
El carcinoma basocelular (CBC) gigante se define como aquel que mide 5cm o más. Aunque la cirugía se considera el tratamiento de elección para cualquier tipo de CBC, en los de gran tamaño, puede ser altamente destructiva. Así, utilizamos la combinación de acitretino oral e imiquimod 5% tópico como tratamiento neoadyuvante en dos pacientes afectos de un CBC gigante. El acitretino es un retinoide sistémico que se utiliza en la prevención primaria del cáncer cutáneo no melanoma. El imiquimod es un inmunomodulador aprobado para el tratamiento, entre otros, de CBC superficiales no faciales menores de 2cm. Estudios previos han demostrado una acción sinérgica anticarcinogénica de ambos fármacos, tanto in vivo como in vitro. Dicha combinación produjo en nuestros pacientes una gran reducción de la masa tumoral, lo que nos permitió aplicar posteriormente un tratamiento definitivo con la remisión completa de los CBC (AU)
Giant basal cell carcinoma (BCC) is defined as a tumor with a diameter of 5cm or more. Surgery, the treatment of choice for any type of BCC, can cause considerable anatomical damage in large tumors. In 2 patients with giant BCC we therefore provided neoadjuvant treatment with a combination of oral acitretin and topical 5% imiquimod. Acitretin is a systemic retinoid used for primary prevention of nonmelanoma skin cancer. Imiquimod is an immunomodulator whose approved indications include treatment of non facial superficial BCC less than 2cm in diameter. Previous studies have demonstrated a synergic anticancer effect of both drugs in vitro and in vivo. This combination produced a marked reduction in tumor mass in our patients. Later we were able to provide definitive treatment, which achieved complete remission of the tumors (AU)
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Terapia Neoadjuvante/instrumentação , Terapia Neoadjuvante/métodos , Interferon-alfa/uso terapêutico , Carcinoma Basocelular/complicações , Carcinoma Basocelular/diagnóstico , Carcinoma Basocelular/tratamento farmacológico , Terapia Neoadjuvante/tendências , Terapia Neoadjuvante , Carcinoma Basocelular/fisiopatologia , Eletrocirurgia/tendências , EletrocirurgiaRESUMO
No disponible
Assuntos
Masculino , Pessoa de Meia-Idade , Humanos , Tuberculose Cutânea/complicações , Tuberculose Cutânea/diagnóstico , Tuberculose Cutânea/terapia , Tuberculose Cutânea/epidemiologia , Radiografia Torácica/métodos , Rifampina/uso terapêutico , Diagnóstico Diferencial , Mycobacterium tuberculosis , Mycobacterium tuberculosis/isolamento & purificação , Mycobacterium tuberculosis/patogenicidade , Estudos Retrospectivos , Biópsia/métodosRESUMO
Dermatoweb es una web de ayuda para el aprendizaje de la Dermatología durante el pregrado. Contiene el programa de la asignatura de la Facultad de Medicina de Lleida, basado principalmente en presentaciones clínicas, unas tablas con el diagnóstico diferencial de los 20 motivos de consulta más frecuentes en Dermatología, unos 200 casos clínicos problema, para estimular el autoaprendizaje, y un temario con los 32 temas que conforman el programa de Dermatología de muchas de las facultades de Medicina. Gracias a la web algunos de nuestros estudiantes superan la asignatura de forma notable sin apenas haber venido a clase. Contiene además unas guías terapéuticas de las dermatosis comunes, un atlas con más de 5.300 fotografías y cerca de 100 vídeos referentes a los procedimientos dermatológicos más empleados que pueden servir de ayuda para el médico de familia, los residentes de Dermatología de los primeros años y el dermatólogo práctico (AU)
Dermatoweb is a website to aid undergraduate dermatology training. It includes the dermatology program of the Lerida Faculty of Medicine, and is based principally on clinical presentations, tables with the differential diagnosis of the 20 most common reasons for dermatologic consultation, about 200 clinical test cases to stimulate self-training, and a subject list with the 32 topics that make up the dermatology syllabus in many faculties of medicine. Thanks to this website, some of our students achieve high marks in dermatology despite hardly coming to classes. In addition, therapeutic guidelines for the common dermatoses can be found on the site, and an atlas with more than 5,300 photographs and almost 100 videos on the more common dermatological procedures; these can serve as a visual aid for family doctors, residents in dermatology in the initial years, and practicing dermatologists (AU)