Detalhe da pesquisa
1.
Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc Natl Acad Sci U S A
; 121(15): e2317274121, 2024 Apr 09.
Artigo
Inglês
| MEDLINE | ID: mdl-38579010
2.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 508(7495): 215-21, 2014 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24695224
3.
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 544(7651): 508, 2017 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28447629
4.
Assessment of interaction potential of AZD2066 using in vitro metabolism tools, physiologically based pharmacokinetic modelling and in vivo cocktail data.
Eur J Clin Pharmacol
; 70(2): 167-78, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24186263
5.
Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project.
Basic Clin Pharmacol Toxicol
; 134(1): 153-164, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37811726
6.
Effect of solvents on the time-dependent inhibition of CYP3A4 and the biotransformation of AZD3839 in human liver microsomes and hepatocytes.
Drug Metab Dispos
; 41(1): 159-69, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23073735
7.
Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1205: 123340, 2022 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35732105
8.
Characterization of niflumic acid as a selective inhibitor of human liver microsomal UDP-glucuronosyltransferase 1A9: application to the reaction phenotyping of acetaminophen glucuronidation.
Drug Metab Dispos
; 39(4): 644-52, 2011 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21245288
9.
A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research.
J Pharm Sci
; 110(1): 2-11, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33096136
10.
Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations.
Sci Rep
; 9(1): 5850, 2019 04 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30971754
11.
Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Nat Commun
; 10(1): 5050, 2019 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31676755
12.
Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound.
Sci Rep
; 8(1): 1925, 2018 01 31.
Artigo
Inglês
| MEDLINE | ID: mdl-29386590
13.
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Nat Commun
; 9(1): 250, 2018 01 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29343827
14.
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Science
; 362(6416): 834-839, 2018 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30442810
15.
Metabolism of 2-substituted quinolines with antileishmanial activity studied in vitro with liver microsomes, hepatocytes and recombinantly expressed enzymes analyzed by LC/MS.
Toxicology
; 235(1-2): 27-38, 2007 Jun 03.
Artigo
Inglês
| MEDLINE | ID: mdl-17434249
16.
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines.
Medchemcomm
; 8(7): 1553-1560, 2017 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30108867
17.
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.
J Med Chem
; 60(5): 2148-2154, 2017 03 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28145708
18.
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
J Med Chem
; 60(10): 4279-4292, 2017 05 25.
Artigo
Inglês
| MEDLINE | ID: mdl-28508636
19.
Characterization of the cytochrome P450 enzymes and enzyme kinetic parameters for metabolism of BVT.2938 using different in vitro systems.
J Pharm Biomed Anal
; 40(5): 1121-30, 2006 Mar 18.
Artigo
Inglês
| MEDLINE | ID: mdl-16307862
20.
Introduction to early in vitro identification of metabolites of new chemical entities in drug discovery and development.
Pharmacol Rep
; 58(3): 341-52, 2006.
Artigo
Inglês
| MEDLINE | ID: mdl-16845208