Detalhe da pesquisa
1.
Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6,5-bicyclic heterocycles.
Bioorg Med Chem Lett
; 33: 127752, 2021 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33359169
2.
Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site.
Molecules
; 26(3)2021 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33504102
3.
Specific Targeting of PEGylated Liposomal Doxorubicin (Doxil®) to Tumour Cells Using a Novel TIMP3 Peptide.
Molecules
; 26(1)2020 Dec 28.
Artigo
Inglês
| MEDLINE | ID: mdl-33379361
4.
Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease.
Bioorg Med Chem Lett
; 28(21): 3458-3462, 2018 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30249354
5.
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat Chem Biol
; 11(3): 189-91, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25622091
6.
Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors.
Bioorg Med Chem Lett
; 26(19): 4606-4612, 2016 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27578246
7.
A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice.
Angiogenesis
; 17(1): 207-19, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-24129822
8.
Covalent targeting of non-cysteine residues in PI4KIIIß.
RSC Chem Biol
; 4(12): 1111-1122, 2023 Nov 29.
Artigo
Inglês
| MEDLINE | ID: mdl-38033723
9.
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.
Bioorg Med Chem Lett
; 22(16): 5222-6, 2012 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22801646
10.
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg Med Chem Lett
; 21(20): 6188-94, 2011 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21903390
11.
4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
Bioorg Med Chem Lett
; 19(9): 2504-8, 2009 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19349179
12.
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.
Bioorg Med Chem Lett
; 19(17): 5261-5, 2009 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19656678
13.
Evidence that all Sorsby's fundus dystrophy mutations cause TIMP3 dimerization resulting in impaired inhibition of VEGFR2.
Genes Dis
; 10(1): 45-47, 2023 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37013036
14.
Activity of matrix metalloproteinase-9 against native collagen types I and III.
FEBS J
; 274(5): 1246-55, 2007 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-17298441
15.
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
J Med Chem
; 59(4): 1370-87, 2016 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-26771203
16.
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.
J Med Chem
; 59(4): 1357-69, 2016 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-26771107
17.
Expression of mutant and wild-type TIMP3 in primary gingival fibroblasts from Sorsby's fundus dystrophy patients.
Biochim Biophys Acta
; 1638(1): 20-8, 2003 May 20.
Artigo
Inglês
| MEDLINE | ID: mdl-12757930
18.
Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha.
Biochim Biophys Acta
; 1626(1-3): 83-91, 2003 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-12697333
19.
Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5' untranslated region in translational control.
Gene
; 359: 99-110, 2005 Oct 10.
Artigo
Inglês
| MEDLINE | ID: mdl-16129570
20.
TIMP3 mutation in Sorsby's fundus dystrophy: molecular insights.
Expert Rev Mol Med
; 7(24): 1-15, 2005 Oct 31.
Artigo
Inglês
| MEDLINE | ID: mdl-16259644