Detalhe da pesquisa
1.
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Nature
; 537(7619): 229-233, 2016 09 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27501246
2.
Guide Swap enables genome-scale pooled CRISPR-Cas9 screening in human primary cells.
Nat Methods
; 15(11): 941-946, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30297964
3.
Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms.
Antimicrob Agents Chemother
; 64(1)2019 12 20.
Artigo
Inglês
| MEDLINE | ID: mdl-31658970
4.
Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of ß-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression.
Antimicrob Agents Chemother
; 63(2)2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30420483
5.
Defects in Efflux (oprM), ß-Lactamase (ampC), and Lipopolysaccharide Transport (lptE) Genes Mediate Antibiotic Hypersusceptibility of Pseudomonas aeruginosa Strain Z61.
Antimicrob Agents Chemother
; 63(7)2019 07.
Artigo
Inglês
| MEDLINE | ID: mdl-31036686
6.
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
PLoS Pathog
; 11(7): e1005058, 2015 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-26186534
7.
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.
Proc Natl Acad Sci U S A
; 110(27): E2510-7, 2013 Jul 02.
Artigo
Inglês
| MEDLINE | ID: mdl-23776209
8.
Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the ß' subunit of RNA polymerase.
Mol Microbiol
; 91(6): 1106-19, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24417450
9.
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.
Nat Chem Biol
; 9(8): 499-506, 2013 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-23770708
10.
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.
Antimicrob Agents Chemother
; 58(9): 5060-7, 2014 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-24913172
11.
In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin.
J Antimicrob Chemother
; 69(1): 41-4, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23887866
12.
Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9.
Malar J
; 12: 316, 2013 Sep 11.
Artigo
Inglês
| MEDLINE | ID: mdl-24025732
13.
Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes.
Proc Natl Acad Sci U S A
; 107(46): 20045-50, 2010 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-21037109
14.
A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma.
APL Bioeng
; 7(2): 026104, 2023 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-37206658
15.
A high-throughput cigarette smoke-treated bronchosphere model for disease-relevant phenotypic compound screening.
PLoS One
; 18(6): e0287809, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37384771
16.
Mechanisms decreasing in vitro susceptibility to the LpxC inhibitor CHIR-090 in the gram-negative pathogen Pseudomonas aeruginosa.
Antimicrob Agents Chemother
; 56(1): 17-27, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-22024823
17.
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 56(4): 1797-809, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22252828
18.
"3D, human renal proximal tubule (RPTEC-TERT1) organoids 'tubuloids' for translatable evaluation of nephrotoxins in high-throughput".
PLoS One
; 17(11): e0277937, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36409750
19.
Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis.
Antimicrob Agents Chemother
; 55(9): 4422-3, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21709101
20.
Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling.
Virology
; 540: 195-206, 2020 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31929001