Detalhe da pesquisa
1.
In vitro results with minimal blood toxicity of a combretastatin A4 analogue.
Invest New Drugs
; 2024 May 17.
Artigo
Inglês
| MEDLINE | ID: mdl-38758478
2.
Comparative chemical and biological hydrolytic stability of homologous esters and isosteres.
J Enzyme Inhib Med Chem
; 37(1): 718-727, 2022 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-35156494
3.
Effect of S-Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel N-acylhydrazone Derivatives at the Adenosine A2A Receptor.
Molecules
; 26(23)2021 Dec 04.
Artigo
Inglês
| MEDLINE | ID: mdl-34885946
4.
Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514.
Molecules
; 26(16)2021 Aug 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34443416
5.
Novel phosphatidylinositol 4-kinases III beta (PI4KIIIß) inhibitors discovered by virtual screening using free energy models.
J Comput Aided Mol Des
; 34(10): 1091-1103, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32601839
6.
Novel VEGFR-2 inhibitors with an N-acylhydrazone scaffold.
Arch Pharm (Weinheim)
; 353(11): e2000130, 2020 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-32667721
7.
What is hidden in the biodiversity? The role of natural products and medicinal chemistry in the drug discovery process.
An Acad Bras Cienc
; 91(supp 3): e20190306, 2019 Jul 29.
Artigo
Inglês
| MEDLINE | ID: mdl-31365612
8.
N-Acylhydrazones as drugs.
Bioorg Med Chem Lett
; 28(17): 2797-2806, 2018 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30006065
9.
Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones.
An Acad Bras Cienc
; 90(1 Suppl 2): 1073-1088, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-29873669
10.
Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation.
J Pharmacol Exp Ther
; 358(2): 315-23, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27194479
11.
LASSBio-579, a prototype antipsychotic drug, and clozapine are effective in novel object recognition task, a recognition memory model.
Behav Pharmacol
; 27(4): 339-49, 2016 06.
Artigo
Inglês
| MEDLINE | ID: mdl-26513177
12.
The total synthesis of calcium atorvastatin.
Org Biomol Chem
; 14(7): 2291-6, 2016 Feb 21.
Artigo
Inglês
| MEDLINE | ID: mdl-26795833
13.
Novel orally active analgesic and anti-inflammatory cyclohexyl-N-acylhydrazone derivatives.
Molecules
; 20(2): 3067-88, 2015 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-25685912
14.
3-Aminothiophene-2-acylhydrazones: non-toxic, analgesic and anti-inflammatory lead-candidates.
Molecules
; 19(6): 8456-71, 2014 Jun 20.
Artigo
Inglês
| MEDLINE | ID: mdl-24955640
15.
Stereochemical insights into ß-amino-N-acylhydrazones and their impact on DPP-4 inhibition.
RSC Adv
; 14(10): 6617-6626, 2024 Feb 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38390500
16.
Cytotoxic and Antiproliferative Activity of LASSBio-2208 and the Attempts to Determine Its Drug Metabolism and Pharmacokinetics In Vitro Profile.
Pharmaceuticals (Basel)
; 17(3)2024 Mar 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38543175
17.
Antiproliferative Activity of N-Acylhydrazone Derivative on Hepatocellular Carcinoma Cells Involves Transcriptional Regulation of Genes Required for G2/M Transition.
Biomedicines
; 12(4)2024 Apr 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38672246
18.
Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats.
Clin Exp Pharmacol Physiol
; 40(7): 404-11, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23573962
19.
Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives.
Molecules
; 18(10): 11683-704, 2013 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-24071978
20.
N-acylhydrazone derivative modulates cell cycle regulators promoting mitosis arrest and apoptosis in estrogen positive MCF-7 breast cancer cells.
Toxicol In Vitro
; 93: 105686, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37652252