1.
Bioorg Med Chem
; 15(7): 2601-10, 2007 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17291769
RESUMO
A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease.