1.
Nucleosides Nucleotides Nucleic Acids
; 26(3): 245-54, 2007.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17454733
RESUMO
Uridine-3'-phosphorothiolate triesters bearing lipophilic moieties were prepared via Michaelis-Arbuzov chemistry. Subsequent deprotection of the S-cholesteryl phosphorothiolate triester afforded the corresponding diester which underwent spontaneous Cyclization to cleanly afford uridine 2',3'-cyclic phosphate. This transesterification reaction could be expedited by treatment with iodine under mild, neutral conditions.